Browsing by Author "ec2a9bf7-3698-4905-b951-84ae1a00c7df"

Now showing items 1-6 of 6

    • Complex mitochondrial dysfunction induced by TPP+-gentisic acid and mitochondrial translation inhibition ... 
      Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Peredo Silva, Liliana; Guzmán Rivera, Daniela; Pavani, Mario; Torrealba, Natalia; Truksa, Jaroslav; Castro Castillo, Vicente; Catalán Díaz, Mabel; Kemmerling Weis, Ulrike; Urra Faúndez, Félix; Ferreira, Jorge (MDPI, 2020)
      The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, ...
    • Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities ... 
      Catalán Díaz, Mabel Elizabeth; Castro Castillo, Vicente; Gajardo de la Fuente, Javier; Aguilera, Jocelyn; Ferreira, Jorge; Ramires Fernández, Ricardo; Olmedo Alegría, Ivonne Odette; Molina Berríos, Alfredo Enrique; Palominos, Charlotte; Valencia, Marcelo; Domínguez, Marta; Souto, José A.; Jara Sandoval, José (Royal Society of Chemistry, 2020)
      Continuous flow chemistry was used for the synthesis of a series of delocalized lipophilic triphenylphosphonium cations (DLCs) linked by means of an ester functional group to several hydroxylated benzoic acid derivatives ...
    • Medicinal chemistry targeting mitochondria: From new vehicles and pharmacophore groups to old drugs with ... 
      Catalán Díaz, Mabel; Olmedo Alegría, Ivonne; Faúndez, Jennifer; Jara Sandoval, José (MDPI, 2020)
      Interest in tumor cell mitochondria as a pharmacological target has been rekindled in recent years. This attention is due in part to new publications documenting heterogenous characteristics of solid tumors, including ...
    • Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines 
      Jara Sandoval, José Antonio; Rojas Rivera, Diego; Castro Castillo, Vicente; Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Parra, Eduardo; Pavani, Mario; Maya Arango, Juan Diego; Ferreira Parker, Jorge; Catalán Díaz, Mabel (Elsevier, 2020)
      Introduction: Colorectal cancer (CRC) is a critical health issue worldwide. The high rate of liver and lung metastasis associated with CRC creates a significant barrier to effective and efficient therapy. Tumour cells, ...
    • Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1 
      Vivar Sánchez, Raúl; Humeres, Claudio; Anfossi, Renatto; Bolívar, Samir; Catalán Díaz, Mabel; Hill, Joseph; Lavandero González, Sergio; Díaz Araya, Guillermo (Elsevier, 2020)
      Cardiac fibroblasts (CFs) are necessary to maintain extracellular matrix (ECM) homeostasis in the heart. Normally, CFs are quiescent and secrete small amounts of ECM components, whereas, in pathological conditions, they ...
    • The Microbiota-Derived Metabolite of Quercetin, 3,4-Dihydroxyphenylacetic Acid Prevents Malignant Transformation ... 
      Catalán Díaz, Mabel; Ferreira, Jorge; Carrasco Pozo, Catalina (MDPI, 2020)
      Meat diet plays a pivotal role in colorectal cancer (CRC). Hemin, a metabolite of myoglobin, produced after meat intake, has been involved in CRC initiation. The compound, 3,4-dihydroxyphenylacetic acid (3,4HPAA) is a ...