Browsing by Author "ec405b76-6fba-4146-8611-9e2408bfb8af"

Now showing items 1-5 of 5

    • A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class ... 
      Kurte, Mónica; López, Mercedes; Aguirre, Adam; Escobar, Alejandro; Aguillón Gutiérrez, Juan Carlos; Charo, Jehad; Larsen, Christian G.; Kiessling, Rolf; Salazar Onfray, Flavio (American Association of Immunologists, 2004)
      Tumor cells treated with IL-10 were shown to have decreased, but peptide-inducible expression of MHC class I, decreased sensitivity to MHC class I-restricted CTL, and increased NK sensitivity. These findings could be ...
    • A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ ... 
      López, Mercedes N.; Pesce Reyes, Bárbara; Kurte, Mónica; Pérez Núñez, Claudio; Segal, Gabriela; Roa, Johanna; Aguillón Gutiérrez, Juan Carlos; Mendoza Naranjo, Ariadna; Gesser, Borbala; Larsen, Christian; Villablanca, Andrea; Choudhury, Aniruddha; Kiessling, Rolf; Salazar Onfray, Flavio (2011)
      We have previously demonstrated that IT9302, a nonameric peptide homologous to the C-terminal domain of human IL-10, mimics several effects of the cytokine including down-regulation of the antigen presentation machinery ...
    • Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1 alpha S-Nitrosylation and Transcriptional ... 
      Sanhueza, Carlos; Castillo Bennett, Jimena; Valenzuela Valderrama, Manuel; Contreras, Pamela; Lobos González, Lorena; Campos, América; Wehinger, Sergio; Lladser, Álvaro; Kiessling, Rolf; Leyton Campos, Lisette; Quest, Andrew F. G. (MDPI, 2020)
      Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the ...
    • Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection ... 
      Lladser, Álvaro; Ljungberg, Karl; Tufvesson, Helena; Tazzari, Marcella; Roos, Anna Karin; Quest, Andrew F. G.; Kiessling, Rolf (2010)
      Survivin is an intracellular tumor-associated antigen that is broadly expressed in a large variety of tumors and also in tumor associated endothelial cells but mostly absent in differentiated tissues. Naked DNA vaccines ...
    • Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for ... 
      López, Mercedes N.; Pereda, Cristian; Ramírez, Marcos; Mendoza Naranjo, Ariadna; Serrano, Antonio; Ferreira, Arturo; Poblete, Rodrigo; Kalergis, Alexis M.; Kiessling, Rolf; Salazar Onfray, Flavio (2007)
      PURPOSE. Uveal melanoma is the most common primary malignant ocular cancer in adults. This tumor has a distinct expression pattern of markers compared with cutaneous melanoma. MC1R is under study as a potential target ...