Browsing by Author "eec1bfdd-7206-4e58-ac08-e9d6468baa46"

Now showing items 1-4 of 4

    • Inhibition of the 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Induces Orofacial Defects in Zebrafish 
      Signore Ahumada, Iskra; Jerez, Carolina; Figueroa, Diego; Suazo Sanhueza, José Lorenzo; Marcelain Cubillos, Katherine; Cerda Arancibia, Óscar; Colombo Flores, Alicia (Wiley, 2016)
      Background: Orofacial clefts (OFCs) are common birth defects, which include a range of disorders with a complex etiology affecting formation of craniofacial structures. Some forms of syndromic OFCs are produced by defects ...
    • KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis 
      Rivas, José; Díaz, Nicolás; Silva, Ian; Morales, Dana; Lavanderos, Boris; Álvarez, Alhejandra; Saldías Maulén, María Paz; Pulgar Pulgar, Eduardo; Cruz Núñez, Pablo; Maureira, Diego; Flores Utreras, Guillermo; Colombo Flores, Alicia; Blanco, Constanza; Contreras Muñoz, Héctor; Jaña, Fabián; Gallegos Méndez, Iván; Concha Nordemann, Miguel; Vergara Jaque, Ariela; Poblete, Horacio; González, Wendy; Varela Lekanda, Diego; Trimmer, James; Cáceres Lluch, Mónica Andrea; Cerda Arancibia, Óscar (Wiley, 2020)
      Transient receptor potential melastatin 4 (TRPM4) is a Ca2+-activated nonselective cationic channel that regulates cell migration and contractility. Increased TRPM4 expression has been related to pathologies, in which ...
    • Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk: a meta-analysis 
      Blanco Castillo, Rafael; Colombo Flores, Alicia; Pardo Vargas, Rosa; Suazo Sanhueza, José Lorenzo (Elsevier, 2016)
      Animal models have shown evidence of the role of maternal methyl donor status and its metabolism (one-carbon metabolism) in normal embryonic maxillofacial development. Nevertheless, studies in humans have shown conflicting ...
    • MTHFR c.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile 
      Ramírez Chau, Cristian Adolfo; Blanco Castillo, Rafael; Colombo Flores, Alicia; Pardo Vargas, Rosa; Suazo Sanhueza, José Lorenzo (Wiley Blackwell, 2016)
      Objective The functional variant within the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene c.677C>T, producing alterations in folate metabolism, has been associated with the risk of non-syndromic cleft lip with or ...