Browsing by Author "ef14f39e-b05c-43f4-a823-3154e3686790"

Now showing items 1-6 of 6

    • Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson's ... 
      Paris Pizarro, Irmgard; Cardenas, Sergio; Lozano, Jorge; Pérez Pastene, Carolina; Graumann, Rebecca; Riveros, Alejandra; Caviedes, Pablo; Segura Aguilar, Juan (2007)
      Four decades after L-dopa introduction to PD therapy, the cause of Parkinson's disease (PD) remains unknown despite the intensive research and the discovery of a number of gene mutations and delections in the pathogenesis ...
    • Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong ... 
      Pérez Pastene, Carolina; Graumann, Rebecca; Díaz Grez, Fernando; Miranda, Marcelo; Venegas, Pablo; Godoy, Osvaldo Trujillo; Layson, Luis; Villagra, Roque; Matamala, José Manuel; Gavia Herrera, Luisa; Segura Aguilar, Juan (2007)
      We have studied the association of a null mutation of Glutathione Transferase M1 (GST M1*0/0) with Parkinson's disease (MIM 168600) in a Chilean population with a strong Amerindian genetic component. We determined the ...
    • DT-diaphorase protects astrocytes from aminochrome-induced toxicity 
      Huenchuguala, Sandro; Muñoz, Patricia; Graumann, Rebecca; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Elsevier, 2016)
      Astrocytes are exposed to aminochrome via the oxidation of dopamine that is taken up from the synaptic cleft after its release from dopaminergic neurons. Glutathione transferase M2-2 (GSTM2) has been shown to protect ...
    • Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy ... 
      Huenchuguala, Sandro; Muñoz, Patricia; Zavala, Patricio; Villa, Mónica; Urriola Cuevas, Carlos; Ahumada, Ulises; Graumann, Rebecca; Nore, Beston F.; Couve, Eduardo; Mannervik, Bengt; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Taylor and Francis Inc., 2014)
      U373MG cells constitutively express glutathione S-transferase mu 2 (GSTM2) and exhibit 3H-dopamine uptake, which is inhibited by 2 μM of nomifensine and 15 μM of estradiol. We generated a stable cell line (U373MGsiGST6) ...
    • Levels of cytokine receptor activator of nuclear factor κB ligand in gingival crevicular fluid in untreated ... 
      Vernal Astudillo, Rolando; Chaparro, Alejandra; Graumann, Rebecca; Puente, Javier; Valenzuela, Maria Antonieta; Gamonal Aravena, Jorge Antonio (2004)
      Background: Receptor activator of nuclear factor κB ligand (RANK-L) is a cytokine involved in the regulation of osteoclastogenesis in bone remodeling and inflammatory osteolysis. One of the major causes of tooth loss in ...
    • Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived ... 
      Paris Pizarro, Irmgard; Martínez Alvarado, Pedro; Pérez Pastene, Carolina; Vieira, Marcelo N.N.; Olea Azar, Claudio; Raisman Vozari, Rita; Cárdenas, Sergio; Graumann, Rebecca; Caviedes Fernández, Pablo; Segura Aguilar, Juan (BLACKWELL PUBLISHING LTD, 2005-03)
      The role of dopamine in iron uptake into catecholaminergic neurons, and dopamine oxidation to aminochrome and its one-electron reduction in iron-mediated neurotoxicity, was studied in RCSN-3 cells, which express both ...