Browsing by Author "ef1be3c9-1127-4997-90ab-815c1d56541d"

Now showing items 1-4 of 4

    • 11β-hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in ... 
      Campino, Carmen; Carvajal, Cristian A.; Cornejo, Javiera; San Martín Núñez, Betty; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Pasini, Francesco; Sateler, Javiera; Baudrand, Rene; Mosso, Lorena; Owen, Gareth I.; Kalergis, Alexis M.; Padilla, Oslando; Fardella, Patricia (2010)
      Cortisol availability is modulated by several enzymes: 11β-HSD2, which transforms cortisol (F) to cortisone (E) and 11β-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5α- and ...
    • Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening 
      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristobal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia-Castillo, Alejandra; Baudrand, Rene; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A. (2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11β-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, ... 
      Baudrand, Rene; Campino, Carmen; Carvajal, Cristian A.; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Sateler, Javiera; Cornejo, Javiera; San Martín Núñez, Betty; Dominguez, Jose M.; Cerda, Jaime; Mosso, Lorena M.; Owen, Gareth I.; Kalergis, Alexis M.; Fardella, Patricia (2011)
      Metabolic syndrome (MetS) may have increased cortisol (F) production caused by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in liver and adipose tissue and/or by HPA axis dysregulation. F is then mainly metabolized by ...
    • Sodium intake is associated with endothelial damage biomarkers and metabolic dysregulation 
      Campino, Carmen; Baudrand, Rene; Valdivia, Carolina; Carvajal, Cristian; Vecchiola, Andrea; Tapia Castillo, Alejandra; Martínez Aguayo, Alejandro; Garcia, Hernán; García Nannig, Lorena; Allende, Fidel; Solari, Sandra; Fuentes, Cristóbal; Lagos, Carlos; Rojas, Maria; Muñoz, Doris; Fardella, Carlos E. (Oxford University Press, 2018)
      BACKGROUND : Mounting evidence has associated high sodium (HS) intake with hypertension, cardiovascular disease, and stroke. We investigated whether HS intake modulates the parameters of endothelial damage, inflammation, ...