Now showing items 1-20 of 21

    • Gonzalez-Candia, Alejandro; Veliz, Marcelino; Carrasco-Pozo, Catalina; Castillo, Rodrigo L.; Cárdenas, J. Cesar; Ebensperger, Germán; Reyes, Roberto V.; Llanos, Aníbal J.; Herrera, Emilio A. (Elsevier B.V., 2019)
      Chronic hypobaric hypoxia during fetal and neonatal life induces neonatal pulmonary hypertension. Hypoxia and oxidative stress are driving this condition, which implies an increase generation of reactive oxygen species ...
    • Castillo, Rodrigo L.; Farías, Jorge G.; Herrera, Emilio A.; Álvarez, Pedro I.; Short, Stefania E.; Tapia, Luis; Carrasco, Rodrigo; Sotomayor Zárate, Ramón (Cardiology Academic Press, 2014)
      Chronic intermittent hypoxia (CIH) induces structural and functional changes in heart, probably associated with ischemia-reperfusion (IR), a pathophysiological event linked with excessive reactive oxygen species generation. ...
    • Rivera, Eugenio; García Herrera, Claudio; González Candia, Alejandro; Celentano, Diego J.; Herrera Vídela, Emilio (Elsevier, 2020)
      Chronic hypoxia is a condition that increases the cardiovascular complications of newborns gestated and born at high altitude (HA), over 2500 m above sea level (masl). A particularly complex pathology is pulmonary arterial ...
    • Casanello, Paola; Schneider, Daniela; Herrera, Emilio A.; Uauy Dagach-Imbarack, Ricardo; Krause, Bernardo J. (Frontiers Media SA, 2014)
      The endothelium is a multifunctional heterogeneous tissue playing a key role in the physiology of every organ. To accomplish this role the endothelium presents a phenotypic diversity that is early prompted during vascular ...
    • Cañas, Daniel; Herrera, Emilio A.; García-Herrera, Claudio; Celentano, Diego; Krause, Bernardo J. (Frontiers Research Foundation, 2017)
      © 2017 Cañas, Herrera, García-Herrera, Celentano and Krause. Aim: Fetal growth restriction (FGR) is associated with a variety of cardiometabolic diseases in adulthood which could involve remodeling processes of the vascular ...
    • Kane, Andrew D.; Niu, Youguo; Herrera, Emilio A.; Morton, A. Jennifer; Giussani, Dino A. (Nature Publishing Group, 2016)
      © 2016, Nature Publishing Group. All rights reserved. Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular ...
    • Tadich, Tamara A.; De Freslón, Inés; Gallo, Carmen; Zúñiga, Jesús M.; Vásquez, Abel E.; Torres, Cristian G.; Tadich, Néstor; Gimpel, Jéssica; Martínez, Claudio; Sandoval, Daniel; Enríquez, Ricardo; Alfaro, Julio; Muñoz, Pablo; Paredes, Rodolfo; Erranz, Benjamín; Carvacho, Ingrid; Mezzano, Marcelo; Herrera, Emilio A. (Universidad de Concepción, Chile, 2020)
      La investigación con fauna silvestre tiene diversos propósitos como la conservación de especies, gestión ambiental y generación de conocimiento. El objetivo de los Comités Institucionales de Cuidado y Uso de Animales (CICUAs) ...
    • Brain, Kirsty L.; Allison, Beth J.; Niu, Youguo; Cross, Christine M.; Itani, Nozomi; Kane, Andrew D.; Herrera, Emilio A.; Giussani, Dino A. (American Physiological Society, 2015)
      © 2015 The Authors. Progress in the study of pregnancy complicated by chronic hypoxia in large mammals has been held back by the inability to measure long-term significant reductions in fetal oxygenation at values similar ...
    • Cañas, Daniel; García-Herrera, Claudio M.; Herrera, Emilio A.; Celentano, Diego J.; Krause, Bernardo J. (Elsevier Ltd, 2018)
      © 2018 Fetal growth restriction (FGR) is a perinatal condition associated with a low birth weight that results mainly from maternal and placental constrains. Newborns affected by this condition are more likely to develop ...
    • González Candia, Alejandro; Candia, Alejandro A.; Figueroa, Esteban G.; Feixes, Elisenda; González Candia, Cristopher; Aguilar, Simón A.; Ebensperger, Germán; Reyes, Roberto V.; Llanos, Aníbal J.; Herrera, Emilio A. (Wiley, 2020)
      Pulmonary arterial hypertension of the neonate (PAHN) is a pathophysiological condition characterized by maladaptive pulmonary vascular remodeling and abnormal contractile reactivity. This is a multifactorial syndrome ...
    • Herrera, Emilio A.; Cifuentes Zúñiga, Francisca; Figueroa, Esteban; Villanueva, Cristian; Hernández, Cherie; Alegría, René; Arroyo Jousse, Viviana; Peñaloza, Estefania; Farías, Marcelo; Uauy Dagach-Imbarack, Ricardo; Casanello, Paola; Krause, Bernardo J. (Blackwell Publishing Ltd, 2017)
      © 2016 The Authors. The Journal of Physiology © 2016 The Physiological SocietyKey points: Intrauterine growth restriction (IUGR) is associated with vascular dysfunction, oxidative stress and signs of endothelial epigenetic ...
    • Lopez-Tello, Jorge; Jimenez-Martinez, Maria Angeles; Herrera, Emilio A.; Krause, Bernardo J.; Sferruzzi-Perri, Amanda N. (W.B. Saunders Ltd, 2018)
      © 2018 Elsevier Ltd Intrauterine growth restriction (IUGR) is a common obstetric complication with immediate and life-long consequences for offspring health. Yet the mechanisms underlying its aetiology require elucidation. ...
    • Cindrova-Davies, Tereza; Herrera, Emilio A.; Niu, Youguo; Kingdom, John; Giussani, Dino A.; Burton, Graham J. (2013)
      Increased vascular impedance in the fetoplacental circulation is associated with fetal hypoxia and growth restriction. We sought to investigate the role of hydrogen sulfide (H2S) in regulating vasomotor tone in the ...
    • Reyes, Roberto V.; Castillo Galán, Sebastián; Hernández, Ismael; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Llanos Mansilla, Jorge (Frontiers Media S.A., 2018)
      © 2018 Reyes, Castillo-Galán, Hernandez, Herrera, Ebensperger and Llanos. The pulmonary arteries are exquisitely responsive to oxygen changes. They rapidly and proportionally contract as arterial PO2 decrease, and they ...
    • Llanos Mansilla, Jorge; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Reyes, Roberto V.; Cabello, Gertrudis; Díaz Díaz, Marcela Cecilia; Giussani, Dino A.; Parer, Julian T. (2012)
      Pulmonary arterial hypertension is one of the most serious pathologies that can affect the 140 million people living at altitudes over 2500. m. The primary emphasis of this review is pulmonary artery hypertension in mammals ...
    • Herrera, Emilio A.; Krause, Bernardo; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Casanello, Paola; Parra Cordero, Mauro; Llanos Mansilla, Jorge (Frontiers Research Foundation, 2014)
      The placenta is the exchange organ that regulates metabolic processes between the mother and her developing fetus. The adequate function of this organ is clearly vital for a physiologic gestational process and a healthy ...
    • Reyes, Roberto V.; Díaz Díaz, Marcela Cecilia; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Quezada, Sebastián A.; Hernández, Ismael; Sanhueza, Emilia M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (Blackwell Publishing Ltd, 2018)
      © 2018 The Physiological Society. Key points: Perinatal hypoxia causes pulmonary hypertension in neonates, including humans. However, in species adapted to hypoxia, such as the llama, there is protection against pulmonary ...
    • Herrera, Emilio A.; Ebensperger, Germán; Hernández, Ismael; Sanhueza, Emilia M.; Llanos, Aníbal J.; Reyes, Roberto V. (Academic Press Inc., 2019)
      Nitric oxide (NO) is the main vasodilator agent that drives the rapid decrease of pulmonary vascular resistance for the respiratory onset during the fetal to neonatal transition. Nevertheless, the enhanced NO generation ...
    • Kane, Andrew D.; Hansell, Jeremy A.; Herrera, Emilio A.; Allison, Beth J.; Niu, Youguo; Brain, Kirsty L.; Kaandorp, Joepe J.; Derks, Jan B.; Giussani, Dino A. (2014)
      Hypoxia is a common challenge to the fetus, promoting a physiological defence to redistribute blood flow towards the brain and away from peripheral circulations. During acute hypoxia, reactive oxygen species (ROS) interact ...
    • Herrera, Emilio A.; Farías, Jorge G.; González Candia, Alejandro; Short, Stefania E.; Carrasco Pozo, Catalina; Castillo, Rodrigo L. (MDPI AG, 2015)
      © 2015 by the authors licensee MDPI.Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) ...