Browsing by Author "f306c3d3-f819-4f4a-84b5-501c65c84aa0"

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    • Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis 
      Beltran, S.; Nassif, M.; Vicencio, E.; Arcos, J.; Labrador, L.; Cortes, B. I.; Cortez, C.; Bergmann, C. A.; Espinoza, S.; Hernandez, M. F.; Matamala, J. M.; Bargsted, L.; Matus, S.; Rojas-Rivera, D.; Bertrand, M. J.M.; Medinas, D. B.; Hetz Flores, Claudio; Manque, P. A.; Woehlbier, U. (BioMed Central Ltd., 2019)
      Background: Amyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. ...
    • Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis 
      Gupta, S.; Read, D. E.; Deepti, A.; Cawley, K.; Gupta, A.; Oommen, D.; Verfaillie, T.; Matus, S.; Smith, M. A.; Mott, J. L.; Agostinis, P.; Hetz Flores, Claudio; Samali, A. (2012)
      Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels. Conversantly, if the damage is too severe and ER function cannot be ...