Now showing items 1-20 of 43

    • Mendoza Torres, Evelyn; Oyarzún, Alejandra; Mondaca Ruff, David; Azocar, Andrés; Chiong Lay, Mario; Castro, Pablo F.; Jalil Milad, Jorge; Lavandero González, Sergio; Ocaranza, María Paz (2015)
      The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and homeostasis due to its influence on the regulation of electrolyte balance, blood pressure, vascular tone and cardiovascular remodeling. ...
    • Gutiérrez, Tomás; Parra, Valentina; Troncoso, Rodrigo; Pennanen, Christian; Contreras Ferrat, Ariel Eduardo; Vásquez Trincado, César Alonso; Morales, Pablo E.; López Crisosto, Camila; Sotomayor Flores, Cristian Alejandro; Chiong Lay, Mario; Rothermel, Beverly A.; Lavandero González, Sergio (BioMed Central Ltd., 2014)
      © 2014 Gutierrez et al.; licensee BioMed Central Ltd. Background: Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes ...
    • Rivera, Juan Carlos; Abrigo, Johanna; Tacchi, Franco; Simón, Felipe; Brandan, Enrique; Santos, Robson A.; Bader, Michael; Chiong Lay, Mario; Cabello Verrugio, Claudio (MDPI, 2020)
      Skeletal muscle atrophy, which occurs in lipopolysaccharide (LPS)-induced sepsis, causes a severe muscle function reduction. The increased autophagy contributes to sepsis-induced skeletal muscle atrophy in a model of LPS ...
    • Norambuena Soto, Ignacio; Ocaranza, María Paz; Cancino Arenas, Nicole; Sanhueza Olivares, Fernanda; Villar Fincheira, Paulina; Leiva Navarrete, Sebastián; Mancilla Medina, Cristian; Moya, Jacqueline; Novoa, Ulises; Jalil, Jorge E.; Castro, Pablo F.; Lavandero González, Sergio; Chiong Lay, Mario (Pergamon-Elsevier Science, 2020)
      The renin-angiotensin system, one of the main regulators of vascular function, controls vasoconstriction, inflammation and vascular remodeling. Antagonistic actions of the counter-regulatory renin-angiotensin system, which ...
    • González, Leticia; Novoa, Ulises; Moya, Jackeline; Gabrielli, Luigi; Jalil Milad, Jorge; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Ocaranza, María Paz (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Hypertension-induced cardiovascular and renal damage can be mediated by activation of the renin-angiotensin-aldosterone system. There are different factors beyond renin-angiotensin-aldosterone system ...
    • Ocaranza, Maria Paz; Lavandero González, Sergio; Jalil Milad, Jorge; Moya, Jaqueline; Pinto, Melissa; Novoa, Ulises; Apablaza, Felipe; González, Leticia; Hernández, Carol; Varas, Manuel; López, René; Godoy, Iván; Verdejo, Hugo; Chiong Lay, Mario (Lippincott Williams and Wilkins, 2010)
      Background: Angiotensin-(1-9) is present in human and rat plasma and its circulating levels increased early after myocardial infarction or in animals treated with angiotensin-converting enzyme inhibitor. However, the ...
    • Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolás; García Nannig, Lorena; Novoa, Ulises; Ayala, Pedro; Díaz Araya, Guillermo; Godoy, Ivan; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Lippincott Williams and Wilkins, 2014)
      BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: ...
    • Peña Oyarzún, Daniel; Bravo Sagua, Roberto; Díaz Vega, Alexis; Aleman, Larissa; Chiong Lay, Mario; García Nannig, Lorena; Bambs, Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio, Catterina; Quest, Andrew F. G.; Criollo Céspedes, Alfredo; Lavandero González, Sergio (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; ...
    • García Miguel, Marina; Riquelme, Jaime A.; Norambuena Soto, Ignacio; Morales, Pablo E.; Sanhueza Olivares, Fernanda; Núñez Soto, Constanza Belén; Mondaca Ruff, David; Cancino Arenas, Nicole; San Martín, Alejandra; Chiong Lay, Mario (Public library science, 2018-05-11)
      Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis ...
    • García Miguel, Marina; Riquelme, Jaime A.; Norambuena Soto, Ignacio; Morales, Pablo E.; Sanhueza Olivares, Fernanda; Núñez Soto, Constanza Belén; Mondaca Ruff, David; Cancino Arenas, Nicole; San Martín, Alejandra; Chiong Lay, Mario (Public Library of Science, 2018)
      This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the ...
    • Pizarro, Marcela; Troncoso Cotal, Rodrigo; Martínez, Gonzalo J.; Chiong Lay, Mario; Castro, Pablo F.; Lavandero González, Sergio (Elsevier, 2016)
      Doxorubicin (Doxo) is one of the most effective anti-neoplastic agents but its cardiotoxicity has been an important clinical limitation. The major mechanism of Doxo-induced cardiotoxicity is associated to its oxidative ...
    • Monsalves Álvarez, Matías; Morales Campos, Pablo; Castro Sepúlveda, Mauricio; Sepúlveda Guzmán, Carlos; Rodríguez Silva, Juan Manuel; Chiong Lay, Mario; Eisner, Verónica; Lavandero González, Sergio; Troncoso Cotal, Rodrigo (MDPI, 2020)
      beta-hydroxybutyrate is the main ketone body generated by the liver under starvation. Under these conditions, it can sustain ATP levels by its oxidation in mitochondria. As mitochondria can modify its shape and function ...
    • Ocaranza, María Paz; Riquelme Meléndez, Jaime; García Nannig, Lorena; Jalil, Jorge; Chiong Lay, Mario; Santos, Robson; Lavandero González, Sergio (Nature, 2020)
      The renin–angiotensin system is an important component of the cardiovascular system. Mounting evidence suggests that the metabolic products of angiotensin I and II — initially thought to be biologically inactive — have ...
    • Castro, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso, Rodrigo; Padilla, Ivonne; Vukasovic, Jose L.; Corbalán, Ramón; Lavandero González, Sergio (Ediciones Doyma, S.L., 2004)
      Introduction and objective. Carvedilol is an antioxidant and adrenergic antagonist with demonstrated benefits in terms of mortality from heart failure (HF). The aim of the present study was to evaluate clinical parameters, ...
    • Winter, José Luis; Castro, Pablo F.; Quintana, Juan Carlos; Altamirano, Rodrigo; Enriquez, Andrés; Verdejo, Hugo E.; Jalil Milad, Jorge; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda, Pablo; Rossel Mariangel, Víctor Alejandro; Sepúlveda Morales, Luis; Chiong Lay, Mario; García Nannig, Lorena; Lavandero González, Sergio (Elsevier, 2014)
      Objectives: Heart failure (HF) is associated with changes in myocardial metabolism that lead to impairment of contractile function. Trimetazidine (TMZ) modulates cardiac energetic efficiency and improves outcomes in ...
    • Morales, Pablo E.; Torres, Gloria; Sotomayor Flores, Cristian Alejandro; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Paredes, Felipe; Chiong Lay, Mario (Academic Press Inc., 2014)
      Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)-mitochondria ...
    • Marambio, Paola; Toro, Barbra; Sanhueza, Carlos; Troncoso, Rodrigo; Parra, Valentina; Verdejo, Hugo; García Nannig, Lorena; Quiroga, Clara; Munafo, Daniela; Díaz Elizondo, Jessica; Bravo Sagua, Roberto; González Burgos, María Julieta; Díaz Araya, Guillermo; Pedrozo Cibils, Zully; Chiong Lay, Mario; Co (2010)
      Aggresomes are dynamic structures formed when the ubiquitin-proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein aggregates are actively transported towards the microtubule-organizing ...
    • Klionsky, Daniel J.; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Glavic Maurer, Álvaro; Corbalán, Ramón; Matus, Soledad; Segura Aguilar, Juan; Hetz Flores, Claudio (Taylor & Francis inc., 2016)
    • Navarro Márquez, Mario F.; Torrealba, Natalia; Troncoso, Rodrigo; Vásquez Trincado, César Alonso; Rodríguez, Marcelo; Morales, Pablo E.; Villalobos, Elisa; Eura, Yuka; García Nannig, Lorena; Chiong Lay, Mario; Klip, Amira; Jaimovich Pérez, Enrique; Kokame, Koichi; Lavandero González, Sergio (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic ...
    • Torrealba, Natalia; Navarro Márquez, Mario F.; Vega Garrido, Valeria; Pedrozo Cibils, Zully; Romero, Diego; Eura, Yuka; Villalobos, Elisa; Carlos Roa, Juan; Chiong Lay, Mario; Kokame, Koichi; Lavandero González, Sergio (Nature Publishing Group, 2017)
      Cardiac hypertrophy is an adaptive response triggered by pathological stimuli. Regulation of the synthesis and the degradation of the Ca2+ channel inositol 1,4,5-trisphosphate receptor (IP3R) affects progression to cardiac ...