Browsing by Author "f4affcbe-088c-4d8b-a3b1-32fb309a3f4e"

Now showing items 1-7 of 7

    • The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells ... 
      Bueno, Susan; González, Pablo A.; Carreño Márquez, Leandro; Tobar, Jaime A.; Mora, Guido C.; Pereda, Cristián; Salazar Onfray, Flavio; Kalergis, Alexis M. (BLACKWELL, 2008-08)
      Infection with Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a severe and lethal systemic disease in mice, characterized by poor activation of the adaptive immune response against Salmonella-derived ...
    • Dexamethasone turns tumor antigen-presenting cells into tolerogenic dendritic cells with T cell inhibitory ... 
      Falcón Beas, Cristián; Tittarelli, Andrés; Mora-Bau, Gabriela; Tempio, Fabián; Pérez Núñez, Claudio; Hevia, Daniel; Behrens, Carolina; Flores, Iván; Falcón-Beas, Felipe; Garrido, Paola; Ascui, Gabriel; Pereda, Cristián; González, Fermín E.; Salazar Onfray, Flavio; López, Mer (Elsevier GmbH, 2019)
      Background: Dendritic cells (DCs) are usually immunogenic, but they are also capable of inducing tolerance under anti-inflammatory conditions. Immunotherapy based on autologous DCs loaded with an allogeneic melanoma cell ...
    • Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation 
      Mendoza Naranjo, Ariadna; Bouma, Gerben; Pereda, Cristián; Ramiŕez, Marcos; Webb, Kevin F.; Tittarelli, Andrés; Loṕez, Mercedes N.; Kalergis, Alexis M.; Thrasher, Adrian J.; Becker, David L.; Salazar Onfray, Flavio (2011)
      Gap junction (GJ) mediates intercellular communication through linked hemichannels from each of two adjacent cells. Using human and mouse models, we show that connexin 43 (Cx43), the main GJ protein in the immune system, ...
    • Molecular signatures associated with tumor-specific immune response in melanoma patients treated with ... 
      García-Salum, Tamara; Villablanca, Andrea; Matthäus, Franziska; Tittarelli, Andrés; Baeza, Mauricio; Pereda, Cristián; Gleisner Muñoz, María Alejandra; González, Fermín; López, Mercedes; Hoheisel, Jörg; Norgauer, Johannes; Gebicke Haerter, Peter; Salazar Onfray, Flavio (Impact Journals LLC, 2018)
      Purpose: We previously showed that autologous dendritic cells (DCs) loaded with an allogeneic heat shock (HS)-conditioned melanoma cell-derived lysate, called TRIMEL, induce T-cell-mediated immune responses in stage IV ...
    • TAPcells, the Chilean dendritic cell vaccine against melanoma and prostate cancer 
      Salazar Onfray, Flavio; Pereda, Cristián; Reyes, Diego; López, Mercedes N. (2013)
      Here we summarize 10 years of effort in the development of a biomedical innovation with global projections. This innovation consists of a novel method for the production of therapeutic dendritic-like cells called Tumor ...
    • Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes ... 
      Tittarelli, Andrés; González, Fermín E.; Pereda, Cristián; Mora, Gabriela; Muñoz, Leonel; Saffie, Carlos; García, Tamara; Díaz, David; Falcón, Cristián; Hermoso, Marcela; López, Mercedes N.; Salazar Onfray, Flavio (2012)
      Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation. Recently, we reported a method for the production of therapeutic DCs ...
    • Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer 
      Rojas-Sepúlveda, Daniel; Tittarelli, Andrés; Gleisner, María Alejandra; Ávalos, Ignacio; Pereda, Cristián; Gallegos, Iván; González, Fermín Eduardo; López, Mercedes Natalia; Butte, Jean Michel; Roa, Juan; Fluxá, Paula; Salazar Onfray, Flavio (Springer Science and Business Media Deutschland GmbH, 2018)
      © 2018, The Author(s). Immunotherapy based on checkpoint blockers has proven survival benefits in patients with melanoma and other malignancies. Nevertheless, a significant proportion of treated patients remains refractory, ...