Browsing by Author "f681251f-40d1-4e1d-b23e-1a023eef8a9a"

Now showing items 1-10 of 10

    • 11β-hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in ... 
      Campino, Carmen; Carvajal, Cristian A.; Cornejo, Javiera; San Martín Núñez, Betty; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Pasini, Francesco; Sateler, Javiera; Baudrand, Rene; Mosso, Lorena; Owen, Gareth I.; Kalergis, Alexis M.; Padilla, Oslando; Fardella, Patricia (2010)
      Cortisol availability is modulated by several enzymes: 11β-HSD2, which transforms cortisol (F) to cortisone (E) and 11β-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5α- and ...
    • A Molecular stratification of chilean gastric cancer patients with potential clinical applicability 
      Pinto, Mauricio; Córdova Delgado, Miguel; Martínez Retamal, Ignacio; Muñoz Medel, Matías; Bravo, M. Loreto; Duran, Doris; Toledo Villanueva, Francisco Javier; Sánchez, César; Acevedo, Francisco; Mondaca, Sebastián; Koch, Erica; Ibáñez, Carolina; Galindo, Héctor; Madrid, Jorge; Nervi, Bruno; Peña, José; Torres, Javiera; Owen, Gareth I.; Corvalán, Alejandro H.; Armisén, Ricardo; Garrido, Marcelo (MDPI, 2020)
      Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require ...
    • Expression of RPRM/rprm in the olfactory system of embryonic zebrafish (Danio rerio) 
      Stanic, Karen; Quiroz, Alonso; Lemus, Carmen G.; Wichmann, Ignacio A.; Corvalan, Alejandro H.; Owen, Gareth I.; Opazo, Juan C.; Concha Nordemann, Miguel; Amigo, Julio D. (Frontiers media SA, 2018)
      The Reprimo (RPRM) family is composed of highly conserved single-exon genes. The expression pattern of this gene family has been recently described during zebrafish (Danio rerio) embryogenesis, and primarily locates in the ...
    • Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening 
      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristobal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia-Castillo, Alejandra; Baudrand, Rene; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A. (2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11β-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, ... 
      Baudrand, Rene; Campino, Carmen; Carvajal, Cristian A.; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Sateler, Javiera; Cornejo, Javiera; San Martín Núñez, Betty; Dominguez, Jose M.; Cerda, Jaime; Mosso, Lorena M.; Owen, Gareth I.; Kalergis, Alexis M.; Fardella, Patricia (2011)
      Metabolic syndrome (MetS) may have increased cortisol (F) production caused by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in liver and adipose tissue and/or by HPA axis dysregulation. F is then mainly metabolized by ...
    • MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer 
      Sandoval Borquez, Alejandra; Polakovicova, Iva; Carrasco Véliz, Nicolás; Lobos González, Lorena; Riquelme, Ismael; Carrasco Aviño, Gonzalo; Bizama, Carolina; Norero, Enrique; Owen, Gareth I.; Roa, Juan; Corvalán, Alejandro H. (Biomed Central Ltd., 2017)
      Background: Multiple aberrant microRNA expression has been reported in gastric cancer. Among them, microRNA-335-5p (miR-335), a microRNA regulated by DNA methylation, has been reported to possess both tumor suppressor and ...
    • Progesterone utilizes distinct membrane pools of tissue factor to increase coagulation and invasion and ... 
      Henríquez, Soledad; Calderón, Claudia; Quezada, Marisol; Oliva, Bárbara; Bravo, Maria Loreto; Aranda, Evelyn; Kato, Sumie; Cuello, Mauricio A.; Gutiérrez, Jorge; Quest, Andrew F. G.; Owen, Gareth I. (2011)
      Tissue factor (TF) serving as the receptor for coagulation factor VII (FVII) initiates the extrinsic coagulation pathway. We previously demonstrated that progesterone increases TF, coagulation and invasion in breast cancer ...
    • Reprimo tissue-specific expression pattern is conserved between zebrafish and human 
      Figueroa, Ricardo J.; Carrasco Aviño, Gonzalo; Wichmann, Ignacio A.; Lange, Martín; Owen, Gareth I.; Siekmann, Arndt F.; Corvalan, Alejandro H.; Opazo, Juan C.; Amigo, Julio D. (Public Library Science, 2017)
      Reprimo (RPRM), a member of the RPRM gene family, is a tumor-suppressor gene involved in the regulation of the p53-mediated cell cycle arrest at G2/M. RPRM has been associated with malignant tumor progression and proposed ...
    • The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish 
      Stanic, Karen; Reig, German; Wichmann, Ignacio A.; Opazo, Juan C.; Owen, Gareth I.; Corvalán, Alejandro H.; Concha, Miguel L.; Amigo, Julio D. (Nature Publishing Group, 2019)
      The Reprimo gene family comprises a group of single-exon genes for which their physiological function remains poorly understood. Heretofore, mammalian Reprimo (RPRM) has been described as a putative p53-dependent tumor ...
    • The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis 
      Torres, Pedro; Díaz Jara, Jorge; Arce, Maximiliano; Silva, Patricio; Mendoza, Pablo; Lois, Pablo; Molina Berríos, Alfredo Enrique; Owen, Gareth I.; Palma Alvarado, Verónica; Torres Gómez, Vicente (Federation of American Societies for Experimental Biology, 2017)
      Saliva is a key factor that contributes to the high efficiency of wound healing in the oral mucosa. This is not only attributed to physical cues but also to the presence of specific peptides in the saliva, such as histatins. ...