Browsing by Author "f87a89d9-4f6b-4ae5-ad51-8edeb8117706"

Now showing items 1-12 of 12

    • Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death 
      Sánchez, Gina; Berrios, Daniela; Olmedo, Ivonne; Pezoa, Javier; Riquelme, Jaime A.; Montecinos, Luis; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2016)
      Inhibitors of the ubiquitin-proteasome system improve hemodynamic parameters and decrease the infarct size after ischemia reperfusion. The molecular basis of this protection is not fully understood since most available ...
    • Angiotensin II-regulated autophagy is required for vascular smooth muscle cell hypertrophy 
      Mondaca Ruff, David; Riquelme, Jaime A.; Quiroga, Clara; Norambuena Soto, Ignacio; Sanhueza Olivares, Fernanda; Villar-Fincheira, Paulina; Hernández-Díaz, Tomás; Cancino Arenas, Nicole; San Martin, Alejandra; García Nannig, Lorena; Lavandero González, Sergio; Chiong Lay, Mario (Frontiers Media S.A., 2019)
      Copyright © 2019 Mondaca-Ruff, Riquelme, Quiroga, Norambuena-Soto, Sanhueza-Olivares, Villar-Fincheira, Hernández-Díaz, Cancino-Arenas, San Martin, García, Lavandero and Chiong.Hypertension is a disease associated to ...
    • Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by ... 
      Davidson, Sean M.; Riquelme, Jaime A.; Takov, Kaloyan; Vicencio, José M.; Boi-Doku, Claire; Khoo, Vanessa; Doreth, Christian; Radenkovic, Dina; Lavandero González, Sergio; Yellon, Derek M. (Blackwell, 2018)
      Many patients with ischaemic heart disease also have diabetes. As myocardial infarction is a major cause of mortality and morbidity in these patients, treatments that increase cell survival in response to ischaemia and ...
    • Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury 
      Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • High fat diet induced obesity produces spontaneous ventricular arrhythmias and increases the activity of ... 
      Sánchez, Gina; Araneda, Felipe; Peña, Juan Pedro; Finkelstein, José Pablo; Riquelme, Jaime A.; Montecinos, Luis; Barrientos Briones, Genaro; Llanos Vidal, Paola; Pedrozo Cibils, Zully; Said, Matilde; Bull Simpfendorfer, Ricardo; Donoso Laurent, Paulina (MDPI, 2018)
      Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, ...
    • Increased production of functional small extracellular vesicles in senescent endothelial cells 
      Riquelme, Jaime; Takov, Kaloyan; Santiago Fernández, Concepción; Rossello, Xavier; Lavandero González, Sergio; Yellon, Derek M.; Davidson, Sean M. (Wiley, 2020)
      Small extracellular vesicles (EVs) are novel players in vascular biology. However, a thorough understanding of their production and function remains elusive. Endothelial senescence is a key feature of vascular ageing and ...
    • New Molecular Insights of Insulin in Diabetic Cardiomyopathy 
      Westermeier, Francisco; Riquelme, Jaime A.; Pavez, Mario; Garrido, Valeria; Díaz, Ariel; Verdejo, Hugo E.; Castro, Pablo F.; García Nannig, Lorena; Lavandero González, Sergio (Frontiers Media S.A., 2016-04)
      Type 2 diabetes mellitus (T2DM) is a highly prevalent disease worldwide. Cardiovascular disorders generated as a consequence of T2DM are a major cause of death related to this disease. Diabetic cardiomyopathy (DCM) is ...
    • Novel therapies targeting cardioprotection and regeneration 
      Garrido, Valeria; Mendoza Torres, Evelyn; Riquelme, Jaime A.; Díaz, Ariel; Pizarro, Marcela; Bustamante, Mario; Chávez, Myra N.; Ocaranza, María Paz; Mellado, Rosemarie; Corbalán, Ramón; Allende Connelly, Miguel; Lavandero González, Sergio (Bentham Science Publishers, 2017)
      Cardiovascular disease is the leading cause of death worldwide. The heart is susceptible to pathologies that impact the myocardium directly, such as myocardial infarction and consequent heart failure, as well as conditions ...
    • Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1–9) through an AT2R and ... 
      Mendoza Torres, Evelyn; Riquelme, Jaime A.; Vielma, Alejandra; Sagredo, Andrea Ramirez; Gabrielli, Luigi; Bravo Sagua, Roberto; Jalil Milad, Jorge; Rothermel, Beverly A.; Sánchez, Gina; Ocaranza, María Paz; Lavandero González, Sergio (Academic Press, 2018)
      © 2018 Elsevier Ltd Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been shown to prevent and revert hypertension and cardiac hypertrophy. We hypothetized that systemic delivery of angiotensin-(1–9) ...
    • Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase ... 
      Rossello, Xavier; Riquelme, Jaime A.; Davidson, Sean M.; Yellon, Derek M. (Wiley, 2018)
      The Reperfusion Injury Salvage Kinase (RISK) pathway is considered the main pro-survival kinase cascade mediating the ischaemic preconditioning (IPC) cardioprotective effect. To assess the role of PI3K-Akt, its negative ...
    • The role of PI3K alpha isoform in cardioprotection 
      Rossello, Xavier; Riquelme, Jaime A.; He, Zhenhe; Taferner, Stasa; Vanhaesebroeck, Bart; Davidson, Sean M.; Yellon, Derek M. (Springer, 2017)
      Ischemic preconditioning (IPC) limits myocardial infarct size through the activation of the PI3K-Akt signal cascade; however, little is known about the roles of individual PI3K isoforms in cardioprotection. We aimed, ...
    • Therapeutic targeting of autophagy in myocardial infarction and heart failure 
      Riquelme, Jaime A.; Chávez, Myra N.; Mondaca Ruff, David; Bustamante, Mario; Vicencio, José M.; Quest, Andrew F. G.; Lavandero González, Sergio (Taylor & Francis, 2016)
      Introduction: Myocardial infarction (MI) is the leading cause of death. When MI is not lethal, heart failure (HF) is a major consequence with high prevalence and poor prognosis. The targeting of autophagy represents a ...