Browsing by Author "fa72faf1-35d3-4a2e-9895-b885d5102dee"

Now showing items 1-4 of 4

    • Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside 
      Palacios, Miriam; Tampe, Ricardo; Campo, Miguel del; Zhong, Ta-Ying; López, Mercedes N.; Salazar Onfray, Flavio; Becker, María Inés (Elsevier, 2018-04-25)
      Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for ...
    • Neosaxitoxin inhibits the expression of inflammation markers of the M1 Phenotype in macrophages 
      Montero Sepúlveda, María Cecilia; Campo, Miguel del; Bono Merino, María Rosa; Simon Zegers, María Valeska; Guerrero Peralta, Julia; Lagos Wilson, Néstor (MDPI, 2020)
      Background: Neosaxitoxin (NeoSTX) has been used as a local anesthetic, but its anti-inflammatory effects have not been well defined. In the present study, we investigate the effects of NeoSTX on lipopolysaccharide ...
    • Neosaxitoxin, a Paralytic Shellfish Poison toxin, effectively manages bucked shins pain, as a local long-acting ... 
      Riquelme, Gricel; Sepúlveda, Joaquín M.; Ghumgham, Zaki Al; Campo, Miguel del; Montero, Cecilia; Lagos, Néstor (Pergamon-Elsevier Science LTD, 2018)
      Local anesthesia is an effective method to control pain. Neosaxitoxin is a phycotoxin whose molecular mechanism includes a reversible inhibition of voltage gated sodium channels at the axonal level, impeding nerve impulse ...
    • The oxygen binding properties of hemocyanin from the mollusk Concholepas concholepas 
      González, Andrea; Nova, Esteban; Campo, Miguel del; Manubens, Augusto; Ioannes, Alfredo de; Ferreira Parker, Jorge; Becker, María Inés (Elsevier, 2017)
      Hemocyanins have highly conserved copper-containing active sites that bind oxygen. However, structural differences among the hemocyanins of various mollusks may affect their physicochemical properties. Here, we studied ...