Now showing items 1-9 of 9

    • Gálvez Cancino, Felipe; Roco, Jonathan; Rojas Colonelli, Nicole; Flores, Camila; Murgas, Paola; Cruz Gómez, Sebastián; Oyarce, Cesar; Varas Godoy, Manuel; Sauma Mahaluf, Daniela; Lladser, Álvaro (Elsevier, 2017)
      DNA vaccination is an attractive approach to elicit tumor-specific cytotoxic CD8(+) T lymphocytes (CTL), which can mediate protective immunity against tumors. To initiate CTL responses, antigen-encoding plasmids employed ...
    • Luarte Navarro, Alejandro; Henzi, Roberto; Fernández, Anllely; Gaete, Diego; Cisternas, Pablo; Pizarro, Matías; Batiz, Luis Federico; Villalobos, Isabel; Masalleras, Matías; Vergara, Rodrigo; Varas Godoy, Manuel; Abarzúa Catalán, Lorena; Herrera Molina, Rodrigo; Lafourcade, Carlos; Wyneken, Úrsula (MDPI, 2020)
      In the last few decades, it has been established that astrocytes play key roles in the regulation of neuronal morphology. However, the contribution of astrocyte-derived small extracellular vesicles (sEVs) to morphological ...
    • Lobos González, Lorena; Bustos, Rocío; Campos, América; Silva, Valeria; Silva, Verónica; Jeldes, Emanuel; Salomón, Carlos; Varas Godoy, Manuel; Cáceres Verschae, Albano; Durán, Eduardo; Vera, Tamara; Ezquer, Fernando; Ezquer, Marcelo; Burzio, Verónica A.; Villegas, Jaime (Nature, 2020)
      During intercellular communication, cells release extracellular vesicles such as exosomes, which contain proteins, ncRNAs and mRNAs that can influence proliferation and/or trigger apoptosis in recipient cells, and have ...
    • Lara, Pablo; Palma Florez, Sujey; Salas Huenuleo, Edison; Polakovicova, Iva; Guerrero, Simón; Lobos González, Lorena; Campos, América; Muñoz, Luis; Jorquera Cordero, Carla; Varas Godoy, Manuel; Cancino, Jorge; Arias, Eloísa; Villegas, Jaime; Cruz, Luis J.; Albericio, Fernando; Araya, Eyleen; Corvalán, Alejandro H.; Quest, Andrew F. G.; Kogan Bocian, Marcelo (BMC, 2020)
      Background Extracellular vesicles (EVs) have shown great potential for targeted therapy, as they have a natural ability to pass through biological barriers and, depending on their origin, can preferentially accumulate at ...
    • Varas Godoy, Manuel; Lladser, Álvaro; Farfan, Nicole; Villota, Claudio; Villegas, Jaime; Tapia Pineda, Julio; Burzio, Luis O.; Burzio, Verónica A.; Valenzuela, Pablo D. T. (Wiley, 2018)
      The family of non-coding mitochondrial RNAs (ncmtRNA) is differentially expressed according to proliferative status. Normal proliferating cells express sense (SncmtRNA) and antisense ncmtRNAs (ASncmtRNAs), whereas tumor ...
    • Cordero, Paloma; Guerrero Moncayo, Alejandra; Reyes, Mónica de los; Varas Godoy, Manuel; Cortez, Jahaira; Torres, Cristian G.; Parraguez, Víctor H.; Peralta, Óscar A. (Frontiers Media, 2021)
      In vitro gamete derivation from stem cells has potential applications in animal reproduction as an alternative method for the dissemination of elite animal genetics, production of transgenic animals, and conservation of ...
    • Pérez Moreno, Pablo; Quezada Meza, Camila; Chávez Almarza, Cristopher; Niechi, Ignacio; Silva Pavez, Eduardo; Trigo Hidalgo, César; Aguayo González, Francisco; Jara Sosa, Lilian; Cáceres Verschae, Albano; Varas Godoy, Manuel; Díaz, Víctor M.; García de Herreros, Antonio; Burzio, Verónica A.; Tapia Pineda, Julio (Frontiers Media, 2020)
      Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. ...
    • Rivas, Solange; Silva, Patricio; Reyes Rojas, Montserrat; Sepúlveda, Hugo; Solano, Luis; Acuña, Juan; Guerrero, Marisol; Varas Godoy, Manuel; Quest, Andrew F. G.; Montecino, Martín; Torres Gómez, Vicente (Nature, 2020)
      Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and ...
    • Gálvez Cancino, Felipe; López, Ernesto; Menares, Evelyn; Díaz, Ximena; Zapata Flores, Camila; Cáceres, Pablo; Hidalgo, Sofía; Chovar, Ornella; Alcántara Hernández, Marcela; Borgna, Vicenzo; Varas Godoy, Manuel; Salazar Onfray, Flavio; Idoyaga, Juliana; Lladser, Álvaro (Taylor & Francis, 2018)
      Memory CD8(+) T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8(+) T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive ...