Browsing by Author "fdbb3b7d-89c9-4a78-b295-e9c5f75ea9db"

Now showing items 1-12 of 12

    • BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response 
      Castillo, Karen; Rojas Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamín; Nassif, Melissa; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena; Glavic Maurer, Álvaro; Hetz Flores, Claudio (2011)
      Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) ...
    • Chaski, a novel drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional ... 
      Delgado, María Graciela; Oliva, Carlos; López, Estefanía; Ibacache, Andrés; Galaz, Alex; Delgado, Ricardo; Barros, L. Felipe; Sierralta, Jimena (Nature Publishing Group, 2018)
      The intercellular transport of lactate is crucial for the astrocyte-to-neuron lactate shuttle (ANLS), a model of brain energetics according to which neurons are fueled by astrocytic lactate. In this study we show that the ...
    • DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology ... 
      Mendoza-Topaz, Carolina; Urra, Francisco; Barría, Romina; Albornoz, Valeria; Ugalde, Diego; Thomas, Ulrich; Gundelfinger, Eckart D.; Delgado, Ricardo; Kukuljan Padilla, Manuel; Sanxaridis, Parthena D.; Tsunoda, Susan; Ceriani, M. Fernanda; Budnik, Vivian; Sierralta, Jimena (2008)
      The synaptic membrane-associated guanylate kinase (MAGUK) scaffolding protein family is thought to play key roles in synapse assembly and synaptic plasticity. Evidence supporting these roles in vivo is scarce, as a consequence ...
    • Functionally heterogenous ryanodine receptors in avian cerebellum 
      Sierralta, Jimena; Fill, Michael; Suárez Isla, Benjamín (1996)
      The functional heterogeneity of the ryanodine receptor (RyR) channels in avian cerebellum was defined. Heavy endoplasmic reticulum microsomes had significant levels of ryanodine and inositol 1,4,5-trisphosphate binding. ...
    • Hindsight regulates photoreceptor axon targeting through transcriptional control of jitterbug/Filamin and ... 
      Oliva, Carlos; Molina-Fernandez, Claudia; Maureira, Miguel; Candia, Noemi; López, Estefanía; Hassan, Bassem; Aerts, Stein; Cánovas, José; Olguín, Patricio; Sierralta, Jimena (John Wiley and Sons Inc., 2015)
      © 2015 Wiley Periodicals, Inc.During axon targeting, a stereotyped pattern of connectivity is achieved by the integration of intrinsic genetic programs and the response to extrinsic long and short-range directional cues. ...
    • Novel isoforms of dlg are fundamental for neuronal development in Drosophila 
      Mendoza, Carolina; Olguín, Patricio; Lafferte, Gabriela; Thomas, Ulrich; Ebitsch, Susanne; Gundelfinger, Eckart D.; Kukuljan Padilla, Manuel; Sierralta, Jimena (2003)
      Drosophila discs-large (dlg) mutants exhibit multiple developmental abnormalities, including severe defects in neuronal differentiation and synaptic structure and function. These defects have been ascribed to the loss of ...
    • p53 is required for brain growth but is dispensable for resistance to nutrient restriction during Drosophila ... 
      Contreras, Esteban G.; Sierralta, Jimena; Glavic Maurer, Álvaro (Public Library Science, 2018)
      Background Animal growth is influenced by the genetic background and the environmental circumstances. How genes promote growth and coordinate adaptation to nutrient availability is still an open question. p53 is a ...
    • Phospholipase C activity in membranes and a soluble fraction isolated from frog skeletal muscle 
      Carrasco, María Angélica; Sierralta, Jimena; Hidalgo Tapia, María Cecilia (1993)
      Highly purified triads and transverse tubules, as well as a soluble fraction isolated from frog skeletal muscle, hydrolyze exogenous phosphatidylinositol 4,5-bisphosphate forming inositol 1,4,5-trisphosphate with maximal ...
    • Regulation of axonal development by the nuclear protein hindsight (pebbled) in the Drosophila visual system 
      Oliva, Carlos; Sierralta, Jimena (Academic Press Inc., 2010)
      The molecules and networks involved in the process of acquisition and maintenance of the form of a mature neuron are not completely known. Using a misexpression screen we identified the gene hindsight as a gene involved ...
    • Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex 
      Oliva, Carlos; Soldano, Alessia; Mora, Natalia; De Geest, Natalie; Claeys, Annelies; Erfurth, Maria-Luise; Sierralta, Jimena; Ramaekers, Ariane; Dascenco, Dan; Ejsmont, Radoslaw K.; Schmucker, Dietmar; Sánchez Soriano, Natalia; Hassan, Bassem A. (Cell Press, 2016)
      The axonal wiring molecule Slit and its Round-About (Robo) receptors are conserved regulators of nerve cord patterning. Robo receptors also contribute to wiring brain circuits. Whether molecular mechanisms regulating these ...
    • Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila 
      Caipo Coral, Lorena; González Ramírez, M. Constanza; Guzmán Palma, Pablo; Contreras, Esteban; Palominos, Tomás; Fuenzalida Uribe, Nicolás; Hassan, Bassem A.; Campusano, Jorge M.; Sierralta, Jimena; Oliva, Carlos (Elsevier, 2020)
      The complexity of the nervous system requires the coordination of multiple cellular processes during development. Among them, we find boundary formation, axon guidance, cell migration and cell segregation. Understanding ...
    • The transcription factor SoxD controls neuronal guidance in the Drosophila visual system 
      Contreras, Esteban G.; Palominos, Tomás; Glavic Maurer, Álvaro; Brand, Andrea H.; Sierralta, Jimena; Oliva, Carlos (Nature Publishing Group, 2018)
      © 2018, The Author(s). Precise control of neurite guidance during development is essential to ensure proper formation of neuronal networks and correct function of the central nervous system (CNS). How neuronal projections ...