Now showing items 1-13 of 13

    • Castillo, Karen; Rojas Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamín; Nassif, Melissa; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena; Glavic Maurer, Álvaro; Hetz Flores, Claudio (2011)
      Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) ...
    • Delgado, María Graciela; Oliva, Carlos; López, Estefanía; Ibacache, Andrés; Galaz, Alex; Delgado, Ricardo; Barros, L. Felipe; Sierralta, Jimena (Nature Publishing Group, 2018)
      The intercellular transport of lactate is crucial for the astrocyte-to-neuron lactate shuttle (ANLS), a model of brain energetics according to which neurons are fueled by astrocytic lactate. In this study we show that the ...
    • Mendoza-Topaz, Carolina; Urra, Francisco; Barría, Romina; Albornoz, Valeria; Ugalde, Diego; Thomas, Ulrich; Gundelfinger, Eckart D.; Delgado, Ricardo; Kukuljan Padilla, Manuel; Sanxaridis, Parthena D.; Tsunoda, Susan; Ceriani, M. Fernanda; Budnik, Vivian; Sierralta, Jimena (2008)
      The synaptic membrane-associated guanylate kinase (MAGUK) scaffolding protein family is thought to play key roles in synapse assembly and synaptic plasticity. Evidence supporting these roles in vivo is scarce, as a consequence ...
    • Sierralta, Jimena; Fill, Michael; Suárez Isla, Benjamín (1996)
      The functional heterogeneity of the ryanodine receptor (RyR) channels in avian cerebellum was defined. Heavy endoplasmic reticulum microsomes had significant levels of ryanodine and inositol 1,4,5-trisphosphate binding. ...
    • Oliva, Carlos; Molina-Fernandez, Claudia; Maureira, Miguel; Candia, Noemi; López, Estefanía; Hassan, Bassem; Aerts, Stein; Cánovas, José; Olguín, Patricio; Sierralta, Jimena (John Wiley and Sons Inc., 2015)
      © 2015 Wiley Periodicals, Inc.During axon targeting, a stereotyped pattern of connectivity is achieved by the integration of intrinsic genetic programs and the response to extrinsic long and short-range directional cues. ...
    • Sepúlveda, Denisse; Rojas Rivera, Diego; Rodríguez, Diego; Kohler, Andrés; Urra, Hery; Carreras Sureda, Amado; Hazari, Younis; Sierralta, Jimena; Hetz Flores, Claudio (Cell Press, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1a is a major UPR transducer, determining cell fate under ER stress. We ...
    • Mendoza, Carolina; Olguín, Patricio; Lafferte, Gabriela; Thomas, Ulrich; Ebitsch, Susanne; Gundelfinger, Eckart D.; Kukuljan Padilla, Manuel; Sierralta, Jimena (2003)
      Drosophila discs-large (dlg) mutants exhibit multiple developmental abnormalities, including severe defects in neuronal differentiation and synaptic structure and function. These defects have been ascribed to the loss of ...
    • Contreras, Esteban G.; Sierralta, Jimena; Glavic Maurer, Álvaro (Public Library Science, 2018)
      Background Animal growth is influenced by the genetic background and the environmental circumstances. How genes promote growth and coordinate adaptation to nutrient availability is still an open question. p53 is a ...
    • Carrasco, María Angélica; Sierralta, Jimena; Hidalgo Tapia, María Cecilia (1993)
      Highly purified triads and transverse tubules, as well as a soluble fraction isolated from frog skeletal muscle, hydrolyze exogenous phosphatidylinositol 4,5-bisphosphate forming inositol 1,4,5-trisphosphate with maximal ...
    • Oliva, Carlos; Sierralta, Jimena (Academic Press Inc., 2010)
      The molecules and networks involved in the process of acquisition and maintenance of the form of a mature neuron are not completely known. Using a misexpression screen we identified the gene hindsight as a gene involved ...
    • Oliva, Carlos; Soldano, Alessia; Mora, Natalia; De Geest, Natalie; Claeys, Annelies; Erfurth, Maria-Luise; Sierralta, Jimena; Ramaekers, Ariane; Dascenco, Dan; Ejsmont, Radoslaw K.; Schmucker, Dietmar; Sánchez Soriano, Natalia; Hassan, Bassem A. (Cell Press, 2016)
      The axonal wiring molecule Slit and its Round-About (Robo) receptors are conserved regulators of nerve cord patterning. Robo receptors also contribute to wiring brain circuits. Whether molecular mechanisms regulating these ...
    • Caipo Coral, Lorena; González Ramírez, M. Constanza; Guzmán Palma, Pablo; Contreras, Esteban; Palominos, Tomás; Fuenzalida Uribe, Nicolás; Hassan, Bassem A.; Campusano, Jorge M.; Sierralta, Jimena; Oliva, Carlos (Elsevier, 2020)
      The complexity of the nervous system requires the coordination of multiple cellular processes during development. Among them, we find boundary formation, axon guidance, cell migration and cell segregation. Understanding ...
    • Contreras, Esteban G.; Palominos, Tomás; Glavic Maurer, Álvaro; Brand, Andrea H.; Sierralta, Jimena; Oliva, Carlos (Nature Publishing Group, 2018)
      © 2018, The Author(s). Precise control of neurite guidance during development is essential to ensure proper formation of neuronal networks and correct function of the central nervous system (CNS). How neuronal projections ...