Browsing by Author "Chiong Lay, Mario"

Now showing items 101-120 of 123

    • Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species 
      Rojas Rivera, Andrés; Díaz Elizondo, Jessica; Parra Ortíz, María Valentina; Salas, Daniela; Contreras Ferrat, Ariel Eduardo; Toro, Barbra; Chiong Lay, Mario; Olea Azar, Claudio; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2009-11-03)
      We investigated the role of Ca2+ in generating reactive oxygen species (ROS) induced by hyposmotic stress (Hypo) and its relationship to regulatory volume decrease (RVD) in cardiomyocytes. Hypo-induced increases in cytoplasmic ...
    • Relation between oxidative stress, catecholamines, and impaired chronotropic response to exercise in patients ... 
      Castro, Pablo; Greig, Douglas; Pérez, Osvaldo; Moraga, Francisco; Chiong Lay, Mario; Díaz Araya, Guillermo; Padilla, Ivonne; Nazzal Nazal, Carolina; Jalil Milad, Jorge; Vukasovic Ramírez, José Luis; Moreno, M.; Corbalán, Ramón; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2003-07-15)
    • Relationship between mechanical and metabolic dyssynchrony with left bundle branch block: Evaluation by ... 
      Castro, Pablo; Winter, José Luis; Verdejo, Hugo; Orellana, Pilar; Quintana, Juan Carlos; Greig, Douglas; Enríquez, Andrés; Sepúlveda, Luis; Concepción, Roberto; Sepúlveda, Pablo; Rossel Mariángel, Víctor; Chiong Lay, Mario; García Nannig, Lorena; Lavandero González, Sergio (2012)
      Background Ventricular dyssynchrony is a common finding in patients with heart failure (HF), especially in the presence of conduction delays. The loss of ventricular synchrony leads to progressive impairment of contractile ...
    • Reply: Dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure 
      Ocaranza, María Paz; Michea Acevedo, Luis; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Lippincott Williams and Wilkins, 2014)
    • Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in ... 
      Ocaranza, María Paz; Rivera, Paulina; Novoa, Ulises; Pinto, Melissa; González, Leticia; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2011-04)
      Background Angiotensin II (Ang II) levels depend on renin, angiotensin-converting enzyme (ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and Ang II levels are associated with higher Rho ...
    • Rho/Rho kinase signal transduction pathway in cardiovascular disease and cardiovascular remodeling. La ... 
      Jalil Milad, Jorge; Lavandero González, Sergio; Chiong Lay, Mario; Ocaranza, María Paz (EDICIONES DOYMA S/L, 2005-08)
      The small guanosine triphosphatase Rho and its target, Rho kinase, play important roles in both blood pressure regulation and vascular smooth muscle contraction. Rho is activated by agonists of receptors coupled to cell ...
    • Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1 
      Carrasco Mujica, Loreto; Cea, Paola; Rocco, Paola; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Sotomayor Flores, Cristian Alejandro; Quiroga, Clara; Criollo Céspedes, Alfredo; Ibarra, Cristián; Chiong Lay, Mario; Lavandero González, Sergio (Wiley-Liss, 2014)
      In the heart, insulin‐like growth factor‐1 (IGF‐1) is a peptide with pro‐hypertrophic and anti‐apoptotic actions. The pro‐hypertrophic properties of IGF‐1 have been attributed to the extracellular regulated kinase (ERK) ...
    • Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure 
      Alcaíno Gálvez, Hernán Alejandro; Greig, Douglas; Chiong Lay, Mario; Verdejo, Hugo; Miranda, Rodrigo; Concepción, Roberto; Vukasovic Ramírez, José Luis; Díaz Araya, Guillermo; Mellado, Rose Marie; García Nannig, Lorena; Salas, Daniela; González, Leticia; Godoy, Iván; Castro, Pablo; Lavandero González, Sergio (ELSEVIER, 2008-07)
      Increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This ...
    • Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability 
      Copaja, Miguel; Venegas, Daniel; Aranguiz, Pablo; Canales, Jimena; Vivar, Raúl; Avalos, Yennifer; García Nannig, Lorena; Chiong Lay, Mario; Olmedo, Ivonne; Catalán, Mabel; Leyton Campos, Lisette; Lavandero González, Sergio; Díaz Araya, Guillermo (Elsevier, 2012)
      Statins reduce the isoprenoids farnesyl and geranylgeranyl pyrophosphate, essential intermediates, which control a diversity of cellular events such as cytoskeleton integrity, adhesion, migration and viability. Cardiac ...
    • Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts 
      Copaja, Miguel; Venegas, Daniel; Aránguiz, Pablo; Canales, Jimena; Vivar, Raúl; Catalán, Mabel; Olmedo, Ivonne; Rodríguez, Andrea E.; Chiong Lay, Mario; Leyton Campos, Lisette; Lavandero González, Sergio; Díaz Araya, Guillermo (2011)
      Several clinical trials have shown the beneficial effects of statins in the prevention of coronary heart disease. Additionally, statins promote apoptosis in vascular smooth muscle cells, in renal tubular epithelial cells ...
    • Sistemas de transducción de señales en la hipertrofia cardíaca 
      Carrasco Alarcón, Loreto del Pilar; Chiong Lay, Mario; Ibarra Iribarren, Cristián; Campos Bastidas, Ximena; Tello, Mario; Sapag Hagar, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2001)
      Los cardiomiocitos son células terminalmente diferenciadas que cesan de dividirse inmediatamentre despúes del nacimiento. Esto hace del corazón un órgano muy vulnerable a eventos isquémicos, tóxicos e inflamatorios. La ...
    • Systemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular ... 
      Gabrielli, Luigi; Castro, Pablo F.; Godoy, Ivan; Mellado, Rosemarie; Bourge, Robert C.; Alcaíno Gálvez, Hernán Alejandro; Chiong Lay, Mario; Greig, Douglas; Verdejo, Hugo; Navarro, Mario; Lopez, Rafael; Toro, Barbra; Quiroga, Clara; Díaz Araya, Guillermo; Lavandero González, Sergio; Garcia, Lo (2011)
      Background: Systemic endothelial dysfunction and increased oxidative stress have been observed in pulmonary arterial hypertension (PAH). We evaluate whether oxidative stress and endothelial dysfunction are associated with ...
    • Systemic vascular cell adhesion molecule-1 predicts the occurrence of post-operative atrial fibrillation 
      Verdejo, Hugo; Roldán, Juan; García Nannig, Lorena; Del Campo, Andrea; Becerra, Elia; Chiong Lay, Mario; Mellado, Rosemarie; Garcia, Amalia; Zalaquett Sepúlveda, Ricardo; Braun, Sandra; Garayar, Bernardita; Gonzalez, Sergio; Lavandero González, Sergio; Corbalán, Ramón (2011)
      Background: Post-operative atrial fibrillation occurs in 30% of patients after on-pump heart surgery and is associated to elevated inflammatory markers. We have evaluated if the systemic biomarkers of inflammation and ...
    • Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes 
      Vicencio, José Miguel; Ibarra, Cristián; Estrada Hormazábal, Manuel; Chiong Lay, Mario; Soto, Dagoberto; Parra, Valentina; Díaz Araya, Guillermo; Jaimovich Pérez, Enrique; Lavandero González, Sergio (ENDOCRINE SOC, 2006-03)
      Androgens are associated with important effects on the heart, such as hypertrophy or apoptosis. These responses involve the intracellular androgen receptor. However, the mechanisms of how androgens activate several membrane ...
    • The role of uric acid in heart failure 
      Alcaíno Olivares, Hernán Alejandro; Greig, Douglas; Castro Agüero, Pablo; Verdejo, Hugo; Mellado, Rose Marie; García Nannig, Lorena; Díaz Araya, Guillermo; Quiroga Lagos, Clara; Chiong Lay, Mario; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2011-04)
      Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart ...
    • The role of uric acid in heart failure Ácido úrico: Una molécula con acciones paradójicas en la insuficiencia ... 
      Alcaíno Gálvez, Hernán Alejandro; Greig, Douglas; Castro, Pablo; Verdejo, Hugo; Mellado, Rosemarie; García Nannig, Lorena; Díaz Araya, Guillermo; Quiroga, Clara; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart ...
    • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling 
      Muñoz, Juan Pablo; Collao, Andrés; Chiong Lay, Mario; Maldonado Vera, Carola Patricia; Adasme, Tatiana; Carrasco Alarcón, Loreto del Pilar; Ocaranza Osses, Paula; Bravo Méndez, Roberto; González, Leticia; Díaz Araya, Guillermo; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-10-09)
      Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) ...
    • Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes 
      Kuzmicic Previtali, Jovan Paolo; Parra, Valentina; Verdejo, Hugo E.; López Crisosto, Camila; Chiong Lay, Mario; García Nannig, Lorena; Jensen, Michael D.; Bernlohr, David A.; Castro, Pablo F.; Lavandero González, Sergio (Elsevier Inc., 2014)
      © 2014 Elsevier Inc. All rights reserved. Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), ...
    • (TTA)n Polymorphism in 3-Hydroxy-3-Methylglutaryl-Coenzyme A and Response to Atorvastatin in Coronary Artery ... 
      Noriega Sepúlveda, Viviana Carolina; Pennanen Saavedra, Christian; Sánchez, P.; Chiong Lay, Mario; Llancaqueo Valeri, Marcelo; Lavandero González, Sergio; Prieto Domínguez, Juan (WILEY-BLACKWELL PUBLISHING, 2009-03)
      3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors have been used clinically for lowering total and low-density lipoprotein cholesterol. Interindividual pharmacological differences observed with this treatment have ...
    • Uric acid, xanthine oxidase and heart failure: Unresolved issues 
      Verdejo, Hugo; Greig, Douglas; Castro, Pablo; Alcaíno Olivares, Hernán Alejandro; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Pizarro, Marcela (OXFORD UNIV PRESS, 2008-12)