Browsing by Author "Lavandero González, Sergio"

Now showing items 101-120 of 312

    • Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy 
      Troncoso, Rodrigo; Vicencio, José Miguel; Parra, Valentina; Nemchenko, Andriy; Kawashima, Yuki; Campo, Andrea del; Toro, Barbra; Battiprolu, Pavan K.; Aranguiz, Pablo; Chiong Lay, Mario; Yakar, Shoshana; Gillette, Thomas G.; Hill, Joseph A.; Abel, Evan Dale; LeRoith, Derek; Lavandero González, Sergio (European Society of Cardiology, 2012)
      Aims Insulin-like growth factor 1 (IGF-1) is known to exert cardioprotective actions. However, it remains unknown if autophagy, a major adaptive response to nutritional stress, contributes to IGF-1-mediated cardioprotec ...
    • Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome ... 
      Kim, Soo Young; Zhang, Xin; Schiattarella, Gabriele G.; Altamirano, Francisco; Ramos, Thais; French, Kristin M.; Jiang, Nan; Szweda, Pamela A.; Evers, Bret M.; May, Herman; Luo, Xiang; Li, Hongliang; Szweda, Luke; Maracajá Coutinho, Vinicius; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Lippincott Williams & Wilkins, 2020)
      BACKGROUND: BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, ...
    • Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and ... 
      Michea Acevedo, Luis; Delpiano Barriga, Ana María; Hitschfeld, C.; Lobos González, Lorena; Lavandero González, Sergio; Marusic, Elisa (ENDOCRINE SOC, 2005-03)
      There is increasing evidence for rapid nongenomic effects of aldosterone. Aldosterone has been demonstrated to alter intracellular pH and calcium in isolated cells. However, few studies have correlated these effects with ...
    • ER-to-mitochondria miscommunication and metabolic diseases 
      López Crisosto, Camila; Bravo Sagua, Roberto; Rodríguez Peña, Marcelo; Mera, Claudia; Castro, Pablo F.; Quest, Andrew F. G.; Rothermel, Beverly A.; Cifuentes, Mariana; Lavandero González, Sergio (Elsevier, 2015)
      © 2015 Elsevier B.V.. Eukaryotic cells contain a variety of subcellular organelles, each of which performs unique tasks. Thus follows that in order to coordinate these different intracellular functions, a highly dynamic ...
    • Erratum 2: Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 ... 
      Altamirano, Francisco; Oyarce, César; Silva, Patricia; Toyos, Marcela; Wilson, Carlos; Lavandero González, Sergio; Uhlen, P.; Estrada, M. (BIOSCIENTIFICA LTD, 2009-09)
      Correction.
    • Erratum to: Mitochondrial control of cell death induced by hyperosmotic stress 
      Criollo Céspedes, Alfredo; Galluzzi, Lorenzo; Chiara Maiuri, M.; Tasdemir, Ezgi; Lavandero González, Sergio; Kroemer, Guido (Springer Science+Business, 2013)
      Errors were inadvertently included in Fig. 6b of the article mentioned above. In particular, the immunoblots depicting the levels of Bcl-XL and Mcl-1, which were originally intended to constitute loading controls for ...
    • Erratum: Mitochondrial control of cell death induced by hyperosmotic stress (Apoptosis (2007) 12:3 DOI: ... 
      Criollo Céspedes, Alfredo; Galluzzi, Lorenzo; Chiara Maiuri, M.; Tasdemir, Ezgi; Lavandero González, Sergio; Kroemer, Guido (2013)
    • Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells 
      Rodríguez, Diego A.; Moncada, Claudio; Núñez González, Marco; Lavandero González, Sergio; Ponnappa, Biddanda C.; Israel Jacard, Yedy (PERGAMON-ELSEVIER SCIENCE LTD, 2004-05)
      Chronic ethanol consumption leads to cell injury in virtually every tissue. Tumor necrosis factor-alpha (TNF-alpha) constitutes a major factor in the development of alcohol-induced liver injury. In alcohol-dependent subjects, ...
    • Ex vivo method to visualize and quantify vascular networks in native and tissue engineered skin 
      Egaña, José T.; Condurache, A.; Lohmeyer, J. A.; Kremer, Mathias; Stoeckelhuber, B. M.; Lavandero González, Sergio; Machens, Hans Günther (SPRINGER, 2009-03)
      Neovascularization plays a pivotal role in tissue engineering and tissue regeneration. However, reliable technologies to visualize and quantify blood vessel networks in target tissue areas are still pending. In this work, ...
    • Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth ... 
      Foncea Avila, Rocío; Gálvez, Anita; Pérez Montes, Viviana; Morales, María Paz; Calixto, Andrea; Meléndez Vergara, Jaime; González Jara, Fabián Rodrigo; Díaz Araya, Guillermo; Sapag Hagar, Mario; Sugden, Peter H.; LeRoith, Derek; Lavandero González, Sergio (ACADEMIC PRESS INC, 2000-07-05)
      This study aims to elucidate the signaling pathway for insulin-like growth factor-1 (IGF-1) in cultured neonatal rat cardiomyocytes and particularly the role of IGF-1 in cardiac apoptosis, IGF-1 stimulated polyphosphoinositide ...
    • Fisión Mitocondrial en la Muerte Celular Programada del Cardiomiocito 
      Parra Ortíz, Valentina María (Universidad de ChilePrograma Cybertesis, 2006)
      El metabolismo y la función fisiológica cardíaca se mantienen gracias a la actividad mitocondrial. Estas últimas son estructuras fundamentales en la fisiología de las células eucariontes dado que participan en una amplia ...
    • FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes 
      Oyarzún, Alejandra P.; Westermeier, Francisco; Pennanen, Christian; López Crisosto, Camila; Parra, Valentina; Sotomayor Flores, Cristian; Sánchez, Gina; Pedrozo Cibils, Zully; Troncoso Cotal, Rodrigo; Lavandero González, Sergio (Elsevier, 2015)
      Aim: FK866 is an inhibitor of the NAD(+) synthesis rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT). Using FK866 to target NAD(+) synthesis has been proposed as a treatment for inflammatory diseases and ...
    • FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation 
      Vivar, Raúl; Humeres, Claudio; Muñoz, Claudia; Boza Fuentes, Pía; Bolivar, Samir; Tapia, Felipe; Lavandero González, Sergio; Chiong Lay, Mario; Díaz Araya, Guillermo (Elsevier, 2016)
      © 2015 Elsevier B.V. Cardiac fibroblast differentiation to myofibroblast is a crucial process in the development of cardiac fibrosis and is tightly dependent on transforming growth factor beta-1 (TGF-β1). The transcription ...
    • FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth 
      Ferdous, Anwarul; Wang, Zhao V.; Luo, Yuxuan; Li, Dan L.; Luo, Xiang; Schiattarella, Gabriele G.; Altamirano, Francisco; May, Herman I.; Battiprolu, Pavan K.; Nguyen, Annie; Rothermel, Beverly A.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Nature, 2020)
      Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and ...
    • GDF-11 prevents cardiomyocyte hypertrophy by maintaining the sarcoplasmic reticulum-mitochondria communication 
      Garrido-Moreno, Valeria; Díaz Vegas, Alexis; López Crisosto, Camila; Troncoso, Mayarling Francisca; Navarro Márquez, Mario F.; García Nannig, Lorena; Estrada, Manuel; Cifuentes, Mariana; Lavandero González, Sergio (Academic Press, 2019)
      Growth differentiation factor 11 (GDF11) is a novel factor with controversial effects on cardiac hypertrophy both in vivo and in vitro. Although recent evidence has corroborated that GDF11 prevents the development of cardiac ...
    • Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and ... 
      Troncoso Cotal, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán S., Juan; Bravo Méndez, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Campo Sfeir, Andrea Estefanía del; Sanhueza Muñoz, Carlos Joaquín; Rodríguez Villarroel, Andrea Elizabeth; Vukasovic Ramírez, José Luis; Mellado, Rose Marie; Greig, Douglas; Castro, Pablo; Lavandero González, Sergio (WILEY-BLACKWELL PUBLISHING, 2009-05)
      We investigated the clinical response of chronic heart failure patients with beta(2)- adrenergic receptor Gln(27)-> Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties. ...
    • Gln27→Gluβ2-adrenergic receptor polymorphism in heart failure patients: Differential clinical and oxidative ... 
      Troncoso Cotal, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán, Juan; Bravo, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Del Campo, Andrea; Sanhueza, Carlos; Rodriguez, Andrea; Vukasovic, José Luis; Mellado, Rosemarie; Greig, Douglas; Castro, Pablo F.; Lavandero González, Sergio (2009)
      We investigated the clinical response of chronic heart failure patients with β2-adrenergic receptor Gln27→Glu polymorphism treated for 6 months with carvedilol, a α/β-antagonist with antioxidant properties. The 6-min. walk ...
    • Glutathione depletion in spermatogonia-type germ cells: Autophagy and Ago2 function 
      Mancilla, H.; Cereceda, K.; Vander Stelt, K.; Villarroel Espíndola, F.; Schraivogel, D.; Meister, G.; Lavandero González, Sergio; Slebe, J. C.; Concha, I. I. (Wiley-Blackwell, 2015)
    • Glutathione Depletion Induces Spermatogonial Cell Autophagy 
      Mancilla, Héctor; Maldonado, Rodrigo; Cereceda, Karina; Villarroel Espíndola, Franz; Montes de Oca, Marco; Angulo, Constanza; Castro, Maite A.; Slebe, Juan C.; Vera, Juan C.; Lavandero González, Sergio (Wiley-Blackwell, 2015)
      The development and survival of male germ cells depend on the antioxidant capacity of the seminiferous tubule. Glutathione (GSH) plays an important role in the antioxidant defenses of the spermatogenic epithelium. Autophagy ...
    • Herp depletion protects from protein aggregation by up-regulating autophagy 
      Quiroga, Clara; Gatica, Damián; Paredes, Felipe; Bravo, Roberto; Troncoso, Rodrigo; Pedrozo Cibils, Zully; Rodríguez, Andrea E.; Toro, Barbra; Chiong Lay, Mario; Vicencio Bustamante, José Manuel; Hetz Flores, Claudio; Lavandero González, Sergio (Elsevier, 2013)
      Herp is an endoplasmic reticulum (ER) stress inducible protein that participates in the ER-associated protein degradation (ERAD) pathway. However, the contribution of Herp to other protein degradation pathways like autophagy ...