Browsing by Author "López Alarcón, Camilo"
Now showing items 21-38 of 38
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International Regulations of Propolis Quality: Required Assays do not Necessarily Reflect their ... Bridi, Raquel; Montenegro, Gloria; Núñez Quijada, Gabriel; Giordano, Ady; Morán Romero, María Fernanda; Jara Pezoa, Isaac; Speisky Cosoy, Hernán; Atala, Elías; López Alarcón, Camilo (Institute of Food Technologists, 2015)Propolis has been proposed as a polyphenolic-rich natural product potentially able to be used for human consumption or even for medicinal proposes. To guarantee a minimum phenolic and flavonoid content and as consequence ...
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Letelier Muñoz, María Eugenia; Entrala Alrruiz, Paz Andrea; López Alarcón, Camilo; González Lira, Víctor; Molina Berríos, Alfredo Enrique; Cortés Troncoso, Juan; Jara Sandoval, José; Santander, P.; Núñez Vergara, Luis (PERGAMON-ELSEVIER SCIENCE, 2007-12)1,4-Dihydropyridines (DHPs) used in the treatment of cardiovascular diseases, are calcium channel antagonists and also antioxidant agents. These drugs are metabolized through cytochrome P-450 oxidative system, majority ...
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Faúndez, M.; Rojas, M.; Bohle, P.; Reyes, C.; Letelier, M. E.; Aliaga, M. E.; Speisky Cosoy, Hernán; Lissi Gervaso, Eduardo A.; López Alarcón, Camilo (2011)The bleaching of the pyrogallol red (PGR) dye mediated by superoxide anion radicals (O2-) generated from the xanthine/xanthine oxidase system (X/XO) was studied by UV-visible spectrophotometry. The absorption band (at 540 ...
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López Alarcón, Camilo; Rocco Klein, Claudio Alberto; Lissi Gervaso, Eduardo A.; Carrasco, C.; Squella Serrano, Juan; Núñez Vergara, Luis; Speisky Cosoy, Hernán (SPRINGER/PLENUM PUBLISHERS, 2005-10)Purpose. The aims of the study are to analyze the interaction between 5-aminosalicylic acid (5-ASA) and peroxyl radicals and to evaluate the effect of some endogenous compounds such as ascorbic acid and amino acids on the ...
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López Alarcón, Camilo; Navarrete Encina, Patricio; Camargo Grandón, Rodrigo; Squella Serrano, Juan; Núñez Vergara, Luis (AMER CHEMICAL SOC, 2003-02)A series of C4-substituted 1,4-dihydropyridines (DHP) with either secondary or tertiary nitrogen in the dihydropyridine ring were synthesized. All of these compounds together with some commercial DHP derivatives were tested ...
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López Alarcón, Camilo; Speisky Cosoy, Hernán; Squella Serrano, Juan; Olea Azar, Claudio; Camargo Grandón, Rodrigo; Núñez Vergara, Luis (KLUWER ACADEMIC/PLENUM PUBL, 2004-10)Purpose. To study the reactivity of C4-substituted 1,4-dihydropyridines (1,4-DHP), with either secondary or tertiary nitrogen in the dihydropyridine ring, toward SIN-1-derived peroxynitrite in aqueous media at pH 7.4. Methods. ...
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Aliaga, Margarita E.; López Alarcón, Camilo; Barriga, Germán; Olea Azar, Claudio; Speisky Cosoy, Hernán (2010)Prompted by the recently reported capacity of the physiologically occurring Cu(I)-[glutathione]2 complex (Cu(I)-[GSH)]2) to reduce oxygen, the effect of various GSH-binding metals (Co2+, Cd2+, Zn2+, Pb2+, Al3+, Hg2+ and ...
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Aliaga, Margarita E.; López Alarcón, Camilo; García Río, Luis; Martín-Pastor, Manuel; Speisky Cosoy, Hernán (2012)The intracellularly-occurring Cu(I)-glutathione complex (Cu(I)-[GSH] 2) has the ability to reduce molecular oxygen into superoxide. Removal of such radicals leads to the irreversible conversion of Cu(I)-[GSH] 2 into the ...
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Aliaga, Margarita E.; López Alarcón, Camilo; Bridi, Raquel; Speisky Cosoy, Hernán (Elsevier, 2016)Binding of copper by reduced glutathione (GSH) is generally seen as a mechanism to lower, if not abolish, the otherwise high electrophilicity and redox activity of its free ions. In recent years, however, this concept has ...
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Speisky Cosoy, Hernán; López Alarcón, Camilo; Olea Azar, Claudio; Sandoval-Acua, Cristian; Aliaga, Margarita E. (2011)The physiologically occurring copper-glutathione complex, [Cu(I)-[GSH]2], has the ability to react continually with oxygen, generating superoxide anions (O 2 -). We addressed here the effects that superoxide removal has ...
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López Alarcón, Camilo; Squella Serrano, Juan; Miranda, Dante; Núñez Vergara, Luis (WILEY-V C H VERLAG GMBH, 2004-04)Spectroelectrochemical and HPLC characterization of the electrochemical oxidation in aqueous medium of a series of six N-1 and C-4 substituted 1,4-dihydropyridines is presented. Based on the analysis of spectra obtained ...
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Aliaga, Margarita; Carrasco Pozo, Catalina; López Alarcón, Camilo; Olea Azar, Claudio; Speisky Cosoy, Hernán (2011)The intracellularly-occurring Cu(I)-glutathione complex (Cu(I)-[GSH](2)) has the ability to reduce molecular oxygen into superoxide radicals (O-2(center dot-)). Based on such ability, we addressed the potential of this ...
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Dorta, E.; Fuentes Lemus, E.; Aspée, A.; Atala, E.; Speisky Cosoy, Hernán; Bridi, R.; Lissi Gervaso, Eduardo A.; López Alarcón, Camilo (Royal Society of Chemistry, 2015)© The Royal Society of Chemistry 2015.In the present work we demonstrate from kinetic studies that under the experimental conditions proposed for the ORAC protocol, ORAC values do not correlate with the capacity of ...
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Escobar-Álvarez, Elizabeth; Leinisch, Fabian; Araya, Gissela; Monasterio Opazo, Octavio; Lorentzen, Lasse G.; Silva, Eduardo; Davies, Michael J.; López Alarcón, Camilo (Elsevier Inc., 2017)© 2017 Elsevier Inc. FtsZ (filamenting temperature-sensitive mutant Z) is a key protein in bacteria cell division. The wild-type Escherichia coli FtsZ sequence (FtsZwt) contains three tyrosine (Tyr, Y) and sixteen methionine ...
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Use of Pyrogallol Red and Pyranine as Probes to Evaluate Antioxidant Capacities towards Hypochlorite Pérez Cruz, Fernanda; Cortés, Constanza J.; Atala, Elías; Bohle, Pamela; Valenzuela, Francisco; Olea Azar, Claudio; Speisky Cosoy, Hernán; Aspée, Alexis; Lissi Gervaso, Eduardo A.; López Alarcón, Camilo; Bridi, Raquel (2013)Hypochlorite is a strong oxidant able to induce deleterious effects in biological systems. The goal of this work was to investigate the use of PGR and PYR as probes in assays aimed at evaluating antioxidant activities ...
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Dorta, Eva; Rodríguez Rodríguez, Elena; Jiménez-Quezada, Andrés; Fuentes-Lemus, Eduardo; Speisky Cosoy, Hernán; Lissi Gervaso, Eduardo; López Alarcón, Camilo (Springer New York LLC, 2017)The potential activity of mango by-products to inhibit the peroxyl radical-mediated oxidation of tryptophan residues (Trp) of myofibrillar proteins (MP) was studied. Extracts of seeds, peels and pulps were studied in terms ...
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Voltammetric behavior and analytical applications of lomefloxacin, an antibacterial fluorquinolone Álvarez Lueje, Alejandro; López Alarcón, Camilo; Núñez Vergara, Luis; Squella Serrano, Juan (AOAC INTERNATIONAL, 2001-05)Lomefloxacin was reduced on a dropping mercury electrode, producing one or more peaks, depending on the pH of the aqueous medium. Coulometric measurements gave an experimental value of 1 electron for the main peak. ...
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López Alarcón, Camilo; Núñez Vergara, Luis; Squella Serrano, Juan (PERGAMON-ELSEVIER SCIENCE, 2003-07-15)A detailed investigation on the electrochemical oxidation of some Hantzsch 1,4-dihydropyridine derivatives with the aim of study the influence of the hydrogen substituent on the N1 position of the heterocyclic ring have ...