Now showing items 21-33 of 33

    • Gálvez, A. S.; Fiedler Temer, Jenny; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2005-09)
      Administration of the P-adrenergic agonist isoproterenol results in cardiac apoptosis. The effect of short-term P-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin ...
    • Castro Gálvez, Pablo; Greig, Douglas; Copaja, Miguel; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo Hernán; Chiong Lay, Mario; Mellado, Rose Marie; Pérez, Osvaldo; Vukasovic Ramírez, José Luis; Díaz Araya, Guillermo; Corbalán, Ramón; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio (Sociedad Chilena de Cardilología y Cirugía Cardiovascular, 2005)
      Los polimorfismos de los receptores β Adrenérgicos (AR) influencian el grado de actividad del receptor. Los βAR tienen un rol importante en la regulación de la contractilidad y podrían tener implicancias en el riesgo de ...
    • Fernández, Carolina; Torrealba, Natalia; Altamirano, Francisco; Garrido Moreno, Valeria Soraya; Vásquez Trincado, César; Flores Vergara, Raúl Alejandro; López Crisosto, Camila; Ocaranza, María Paz; Chiong Lay, Mario Martin; Pedrozo Cibils, Zully Rocío Evangelina; Lavandero González, Sergio (Public Library Science, 2021)
      Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical ...
    • Ocaranza, María Paz; Díaz Araya, Guillermo; Carreño, J. E.; Muñoz, David; Riveros, Juan Pablo; Jalil Milad, Jorge; Lavandero González, Sergio (AMER PHYSIOLOGICAL SOC, 2004-02-01)
      In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE gene ...
    • Gálvez, Anita; Ocaranza, María Paz; Lavandero González, Sergio; Jalil Milad, Jorge (Sociedad Española de Cardiología, 2001)
      En este modelo experimental de HVI hipertensiva mixta existe una activación temprana de la ECA plasmática y cardíaca. La administración precoz de un IECA previene el desarrollo de hipertensión e HVI al inhibir el aumento ...
    • Gálvez, Anita; Morales, María Paz; Eltit Ortega, José Miguel; Ocaranza, María Paz; Carrasco Alarcón, Loreto del Pilar; Campos Bastidas, Ximena; Sapag Hagar, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (SPRINGER-VERLAG, 2001-05)
      In all cell types, the maintenance of normal cell volume is an essential homeostatic function. Relatively little is known about the induction of apoptosis by hyperosmotic stress and its molecular mechanism in terminally ...
    • Ocaranza, María Paz; Michea Acevedo, Luis; Chiong Lay, Mario; Lagos, Carlos F.; Lavandero González, Sergio; Jalil Milad, Jorge (Portland Press Ltd, 2014)
      Chronic RAS (renin-angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic and atherogenic effects ...
    • Rivera, Paulina; Ocaranza, María Paz; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2007-10)
      The RhoA/Rho kinase (ROCK) pathway is a new mechanism of remodeling and vasoconstriction. Few data are available regarding ROCK activation when angiotensin I-converting enzyme is high and blood pressure is normal. We ...
    • Ocaranza, María Paz; Rivera, Paulina; Novoa, Ulises; Pinto, Melissa; González, Leticia; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2011-04)
      Background Angiotensin II (Ang II) levels depend on renin, angiotensin-converting enzyme (ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and Ang II levels are associated with higher Rho ...
    • Ocaranza, María Paz; Moya, Jackeline; Jalil, Jorge E.; Lavandero González, Sergio; Kalergis, Alexis M.; Molina, Cristián; Gabrielli, Luigi; Godoy, Iván; Córdova, Samuel; Castro, Pablo; Mac Nab, Paul; Rossel Mariángel, Víctor; García, Lorena; González, Javier; Mancilla, Cristián; Fierro, Camila; Farías, Luis (Wiley, 2020)
      Background: Increased Rho-kinase activity in circulating leucocytes is observed in heart failure with reduced ejection fraction (HFrEF). However, there is little information in HFrEF regarding other Rho-kinase pathway ...
    • Jalil Milad, Jorge; Lavandero González, Sergio; Chiong Lay, Mario; Ocaranza, María Paz (EDICIONES DOYMA S/L, 2005-08)
      The small guanosine triphosphatase Rho and its target, Rho kinase, play important roles in both blood pressure regulation and vascular smooth muscle contraction. Rho is activated by agonists of receptors coupled to cell ...
    • Villar Fincheira, Paulina Fernanda; Paredes, Aaron J.; Hernández Díaz, Tomás Alonso; Norambuena Soto, Ignacio Esteban; Cancino Arenas, Nicole Ester; Sanhueza Olivares, Fernanda; Contreras Briceño, Felipe; Mandiola, Jorge; Bruneau Leyton, Nicole Nayira; García Nannig, Lorena; Ocaranza, María Paz; Troncoso Cotal, Rodrigo Hernán; Gabrielli, Luigi; Chiong Lay, Mario Martin (Frontiers Media, 2021)
      Little is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling. We sought to evaluate the ...
    • Jalil Milad, Jorge; Lavandero González, Sergio; Chiong Lay, Mario; Ocaranza, María Paz (Sociedad Española de Cardiología, 2005)
      La guanosina trifosfatasa pequeña Rho y su blanco Rho-cinasa desempeñan un papel importante en la regulación de la presión arterial y en la contracción de la musculatura lisa vascular. Diversos agonistas de los receptores ...