Browsing by Author "Quintanilla González, María Elena"
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Israel Jacard, Yedy; Rivera Meza, Mario; Karahanian, Eduardo; Quintanilla González, María Elena; Tampier de Jong, Lutske; Morales Retamales, Paola; Herrera-Marschitz Muller, Mario (FRONTIERS RESEARCH FOUNDATION, 2013-07-08)Ethanol is metabolized into acetaldehyde mainly by the action of alcohol dehydrogenase in the liver, while mainly by the action of catalase in the brain. Aldehyde dehydrogenase-2 metabolizes acetaldehyde into acetate in ...
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Ocaranza, Paula; Quintanilla González, María Elena; Tampier de Jong, Lutske; Karahanian, Eduardo; Sapag, Amalia; Israel Jacard, Yedy (2008)Background: Some gene polymorphisms strongly protect against the development of alcoholism. A large proportion of East Asians carry a protective inactivating mutation in aldehyde dehydrogenase (ALDH2*2). These subjects ...
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Ezquer, Fernando; Morales Retamales, Paola; Quintanilla González, María Elena; Santapau, Daniela; Lespay Rebolledo, Carolyne; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Nature, 2018)Chronic alcohol intake leads to neuroinflammation and astrocyte dysfunction, proposed to perpetuate alcohol consumption and to promote conditioned relapse-like binge drinking. In the present study, human mesenchymal stem ...
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Karahanian, Eduardo; Rivera Meza, Mario; Tampier de Jong, Lutske; Quintanilla González, María Elena; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Society for the Study of Addiction, 2014)Previous studies suggest that acetaldehyde generated from ethanol in the brain is reinforcing. The present studies tested the feasibility of achieving a long-term reduction of chronic and post-deprivation binge ethanol ...
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Sapag, Amalia; Tampier de Jong, Lutske; Prieto, A.; Quintanilla González, María Elena; Moncada, C.; Israel Jacard, Yedy (LIPPINCOTT WILLIAMS & WILKINS, 2003-08)Genetic factors influence alcohol consumption and alcoholism. A number of groups have bred alcohol drinker and non drinker rat strains, but genetic determinants remain unknown. The University of Chile rat lines UChA (low ...
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Rivera Meza, Mario; Quintanilla González, María Elena; Bustamante Cádiz, Diego; Delgado Arriagada, Ricardo; Buscaglia Fernández, Marianne; Herrera-Marschitz Muller, Mario (Research Society on Alcoholism, 2014)Background: A number of studies have shown that ethanol (EtOH) activates dopamine neurocircuitries and is self-administered into the ventral tegmental area (VTA) of the rat brain. In vitro and in silico studies have ...
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Karahanian, Eduardo; Rivera Meza, Mario; Quintanilla González, María Elena; Muñoz, Daniel; Fernández, Katia; Israel Jacard, Yedy (Oxford University Press, 2015)
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Rivera Meza, Mario; Quintanilla González, María Elena; Tampier de Jong, Lutske (OXFORD UNIV PRESS, 2012-04)Aims: To mimic, in an animal model of alcoholism, the protective phenotype against alcohol consumption observed in humans carrying a fast alcohol dehydrogenase (ADH1B*2) and an inactive aldehyde dehydrogenase (ALDH2*2). ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena (2006)An association between saccharin consumption and alcohol intake has been observed in rodent lines genetically developed for alcohol preference or alcohol avoidance. It has also been proposed that a sweetened alcohol solution ...
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Rivera Meza, Mario; Berríos Cárcamo, Pablo; Herrera-Marschitz Muller, Mario; Quintanilla González, María Elena (Oxford Univ Press, 2015)
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Quintanilla González, María Elena; Tampier de Jong, Lutske (1989)Mitochondrial function appears to be an early target for ethanol toxicity, however it is not clear to what extent the effects of ethanol, which occur at levels of intake lower than those already reported in the literature, ...
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Mattalloni, Mara Soledad; Albrecht, Paula Alejandra; Salinas Luypaert, Catalina; Deza-Ponzio, Romina; Quintanilla González, María Elena; Herrera Marschitz, Mario; Cancela, Liliana Marina; Rivera Meza, Mario; Virgolini, Miriam Beatriz (Elsevier B.V., 2019)© 2018 Elsevier B.V. Lead (Pb) is a developmental neurotoxicant. We have demonstrated that perinatally Pb-exposed rats consume more ethanol than their control counterparts, a response that seems to be mediated by catalase ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena; Israel Jacard, Yedy (BLACKWELL PUBLISHING, 2008-06)Background: Disulfiram, an inhibitor of aldehyde dehydrogenase used in the treatment of alcoholism, is an effective medication when its intake is supervised by a third person. However, its therapeutic efficacy varies ...
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Sotomayor Zárate, Ramón; Gysling, Katia; Busto, Usoa E.; Cassels Niven, Bruce; Tampier de Jong, Lutske; Quintanilla González, María Elena (Springer, 2013)Rationale Neuronal nicotinic acetylcholine receptors (nAChRs) are pharmacological targets that have recently been implicated in the reinforcing effects ofmany drugs of abuse, including ethanol. Varenicline and cytisine ...