Browsing by Author "Speisky Cosoy, Hernán"
Now showing items 21-31 of 31
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Letelier Muñoz, María Eugenia; Pimentel Miranda, Alejandra Patricia; Pino, Patricia; Lepe Agrodnik, Ana María; Faúndez Cáceres, Mario Antonio; Aracena Parks, Paula; Speisky Cosoy, Hernán (BLACKWELL PUBLISHING, 2005-06)Activation of microsomal UDP-glucuronyltransferase (UDPGT) activity by treatment of hepatic microsomes with either detergents or Fe3+/ascorbate pro-oxidant system has been reported; however, definite mechanisms underlying ...
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Rodríguez Borges, Jorge; Arán, Vicente J.; Boiani, Lucía; Olea Azar, Claudio; Lavaggi, María Laura; González, Mercedes; Cerecetto, Hugo; Diego Maya, Juan; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2009-12-15)New 5-nitroindazole derivatives were developed and their antichagasic properties studied. Eight compounds (14-18, 20, 26 and 28) displayed remarkable in vitro activities against Trypanosoma cruzi (T. cruzi). Its unspecific ...
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Folch Cano, Christian; Guerrero, Juan; Speisky Cosoy, Hernán; Jullian Matthaei, Carolina; Olea Azar, Claudio (Springer, 2013)The present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like b-cyclodextrin (bCD), heptakis(2,6 di-O-methyl)-b-cyclodextrin (DMbCD), ...
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Speisky Cosoy, Hernán; Squella Serrano, Juan; Núñez Vergara, Luis (1995)This article critically reviews the recent specialized literature concerning the influence of the stereochemical nature of quiral drugs on the pharmacokinetic processes and its pharmacological implications. Evidence is ...
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Sandoval Acuña, Cristián; Ferreira Parker, Jorge; Speisky Cosoy, Hernán (Elsevier, 2014)Polyphenols, ubiquitously present in fruits and vegetables, have been traditionally viewed as antioxidant molecules. Such contention emerged, mainly from their well established in vitro ability to scavenge free radicals ...
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Gotteland, Martín; Jiménez, Inés; Brunser, Oscar; Guzmán, Leda; Romero, Sergio; Cassels Niven, Bruce; Speisky Cosoy, Hernán (Georg Thieme, 1996-11-23)The cytoprotective and anti-inflammatory effects of boldine in an experimental model of acute colitis are reported. The administration of boldine to animals with colitis induced by the intrarectal administration of ...
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Asencio,; Cassels Niven, Bruce; Speisky Cosoy, Hernán; Valenzuela, (1993)
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López Alarcón, Camilo; Rocco Klein, Claudio Alberto; Lissi Gervaso, Eduardo A.; Carrasco, C.; Squella Serrano, Juan; Núñez Vergara, Luis; Speisky Cosoy, Hernán (SPRINGER/PLENUM PUBLISHERS, 2005-10)Purpose. The aims of the study are to analyze the interaction between 5-aminosalicylic acid (5-ASA) and peroxyl radicals and to evaluate the effect of some endogenous compounds such as ascorbic acid and amino acids on the ...
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López Alarcón, Camilo; Speisky Cosoy, Hernán; Squella Serrano, Juan; Olea Azar, Claudio; Camargo Grandón, Rodrigo; Núñez Vergara, Luis (KLUWER ACADEMIC/PLENUM PUBL, 2004-10)Purpose. To study the reactivity of C4-substituted 1,4-dihydropyridines (1,4-DHP), with either secondary or tertiary nitrogen in the dihydropyridine ring, toward SIN-1-derived peroxynitrite in aqueous media at pH 7.4. Methods. ...
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Folch Cano, Christian; Olea Azar, Claudio; Speisky Cosoy, Hernán (Elsevier, 2013)In this studywefindthe possible structural factors that can determine the adsorption process ofsomepure phenolic compounds (PC) onto polyvinylpolypyrrolidone (PVPP), analyzing their adsorption isotherms by using the ...
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Pastene, Edgar; Gómez, Maritza; Speisky Cosoy, Hernán; Núñez Vergara, Luis (SOC BRASILEIRA QUIMICA, 2009)An apparatus which allows the direct measurement of the antioxidant capacity of volatiles compounds emitted from some herbs and culinary spices is described. The device comprises: a sample chamber, a mixing chamber, a pump ...