Browsing by Subject "Brain"

Now showing items 21-26 of 26

    • Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner ... 
      Délano Reyes, Paul; Belkhiria, Chama; Vergara Ortúzar, Rodrigo; Martínez Sabja, Melissa; Leiva Cifuentes, Alexis; Andrade, Maricarmen; Marcenaro, Bruno; Torrente Avendaño, Mariela; Maass Oñate, Juan C.; Delgado Derio, Carolina (Public Library Science, 2020)
      Epidemiological evidence shows an association between hearing loss and dementia in elderly people. However, the mechanisms that connect hearing impairments and cognitive decline are still unknown. Here we propose that a ...
    • Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila 
      Caipo Coral, Lorena; González Ramírez, M. Constanza; Guzmán Palma, Pablo; Contreras, Esteban; Palominos, Tomás; Fuenzalida Uribe, Nicolás; Hassan, Bassem A.; Campusano, Jorge M.; Sierralta, Jimena; Oliva, Carlos (Elsevier, 2020)
      The complexity of the nervous system requires the coordination of multiple cellular processes during development. Among them, we find boundary formation, axon guidance, cell migration and cell segregation. Understanding ...
    • Spatial maps and oscillations in the healthy hippocampus of octodon degus, a natural model of sporadic ... 
      Mugnaini, Matias; Polania Caviedes, Diana Marcela; Díaz, Yannina; Ezquer, Marcelo; Ezquer, Fernando; Deacon, Robert M. J.; Cogram, Patricia; Kropf, Emilio (Nature, 2022)
      The Octodon degus is a South American rodent that is receiving increased attention as a potential model of aging and sporadic late-onset Alzheimer's disease (AD). Impairments in spatial memory tasks in Octodon degus have ...
    • Sub-chronic iron overload triggers oxidative stress development in rat brain: implications for cell protection 
      Piloni, Natacha E.; Perazzo, Juan C.; Fernández Arancibia, Virginia; Videla Cabrera, Luis; Puntarulo, Susana (Springer, 2016)
      This work was aimed to test the hypothesis that sub-chronic administration of iron-dextran (Fe-dextran) (six doses of 50 mg Fe-dextran/kg) to rats triggers a transient oxidative stress in brain and mechanisms of cellular ...
    • The Corticofugal Effects of Auditory Cortex Microstimulation on Auditory Nerve and Superior Olivary Complex ... 
      Aedo Sánchez, Cristian; Terreros, Gonzalo; León, Alex; Délano Reyes, Paul (Public Library Science, 2016)
      Background and Objective The auditory efferent system is a complex network of descending pathways, which mainly originate in the primary auditory cortex and are directed to several auditory subcortical nuclei. These ...
    • Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent ... 
      Jury, Nur; Abarzúa, Sebastián; Díaz, Iván; Guerra, Miguel V.; Ampuero, Estibaliz; Cubillos, Paula; Martínez, Pablo; Herrera Soto, Andrea; Arredondo, Cristian; Rojas, Fabiola; Manterola Zúñiga, Marcia; Rojas, Adriana; Montecino, Martín; Varela Nallar, Lorena; van Zundert, Brigitte (BMC, 2020)
      Background Hexanucleotide repeat expansions of the G(4)C(2) motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues ...