Browsing by Author "Segura Aguilar, Juan"
Now showing items 41-46 of 46
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Segura Aguilar, Juan (Medknow Publications & Media Pvt, 2017)For 50 years ago was introduced L-3,4-dihydroxyphenylalanine (L-dopa) in Parkinson's disease treatment and during this significant advances has been done but what trigger the degeneration of the nigrostriatal system remain ...
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One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity Villa, Monica; Muñoz, Patricia; Ahumada-Castro, Ulises; Paris, Irmgard; Jiménez, Ana; Martínez, Isabel; Sevilla, Francisca; Segura Aguilar, Juan (2013)6-Hydroxydamine has widely been used as neurotoxin in preclinical studies related on the neurodegenerative process of dopaminergic neurons in Parkinson's disease based on its ability to be neurotoxic as a consequence of ...
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Muñoz, Patricia; Paris Pizarro, Irmgard; Sanders, Laurie H.; Greenamyre, J. Timothy; Segura Aguilar, Juan (2012)We tested the hypothesis that both VMAT-2 and DT-diaphorase are an important cellular defense against aminochrome-dependent neurotoxicity during dopamine oxidation. A cell line with VMAT-2 and DT-diaphorase over-expressed ...
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Muñoz, Patricia; Huenchuguala, Sandro; Paris Pizarro, Irmgard; Cuevas, Carlos; Villa, Monica; Caviedes, Pablo; Segura Aguilar, Juan; Tizabi, Yousef (2012)Parkinson's disease is a debilitating progressive neurodegenerative disorder that results from the loss of or damage to dopaminergic cells containing neuromelanin in the substantia nigra (SN). The underlying neurodegenerative ...
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Aguirre, Pabla; Urrutia, Pamela J.; Tapia, Victoria; Villa, Monica; Paris Pizarro, Irmgard; Segura Aguilar, Juan; Núñez González, Marco (2012)Hallmarks of idiopathic and some forms of familial Parkinson's disease are mitochondrial dysfunction, iron accumulation and oxidative stress in dopaminergic neurons of the substantia nigra. There seems to be a causal link ...
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Segura Aguilar, Juan; Paris Pizarro, Irmgard; Muñoz, Patricia (Birkhauser Verlag AG, 2016)