Now showing items 61-80 of 318

    • Cassels Niven, Bruce; Asencio, Marcelo (Springer, 2010-03-25)
      The continued advance of HIV-AIDS makes the development of relatively inexpensive, freely accessible, and mechanistically more diverse antiviral therapies an urgent need. Natural products are, directly or indirectly, ...
    • Backhouse Erazo, Nadine; Delporte Vergara, Carla; Givernau, M.; Cassels Niven, Bruce; Valenzuela, A.; Speisky Cosoy, Hernán (Birkhäuser Verlag, 1994-03-02)
      Boldine, an antioxidant alkaloid isolated from Peumus boldus, exhibits a dose-dependent anti-inflammatory activity in the carrageenan-induced guinea pig paw edema test with an oral EDso of 34 mg/kg. Boldine also reduces ...
    • Liberto, Melina Di; Svetaz, Laura; Furlán, Ricardo L. E.; Zacchino, Susana; Delporte Vergara, Carla; Novoa, Marco A.; Asencio, Marcelo; Cassels Niven, Bruce (EDITORIAL BOARD, 2010-05-20)
      A saponin-rich extract of Phytolacca dioica L. berries, its acid hydrolysate, and its major aglycone, phytolaccagenin, were assayed for antifungal activity against ATCC standard cultures of Candida albicans and Cryptococcus ...
    • Backhouse, N.; Delporte, C.; Negrete, R.; Salinas, P.; Pinto, A.; Aravena, S.; Cassels Niven, Bruce (Swets en Zeitlinger B.V., 1996)
      The antipyretic and antiinflammatory properties of the infusions and methanol extracts of the whole plant of Cuscuta chilensis Ker-Gawl. and of the aerial parts of Cestrum parqui L'Hérit. and Psoralea glandulosa L. were ...
    • Backhouse,; Delporte,; Negrete,; Salinas,; Pinto Pinto, Andrea Alejandra; Aravena,; Cassels Niven, Bruce (1996)
      The antipyretic and antiinflammatory properties of the infusions and methanol extracts of the whole plant of Cuscuta chilensis Ker-Gawl. and of the aerial parts of Cestrum parqui L'Herit. and Psoralea glandulosa L. were ...
    • Backhouse, N.; Delporte, C.; Negrete, R.; Suárez, S.; Cassels Niven, Bruce; Breitmaier, E.; Schneider, C. (Swets en Zeitlinger B.V., 1997)
      Acaena splendens H. et A., Rosaceae, has been used in Chilean traditional medicine for the treatment of fever and inflammation. The antipyretic and antiinflammatory properties of the infusion, methanol, petroleum ether and ...
    • Backhouse,; Delporte,; Negrete,; Suarez,; Cassels Niven, Bruce; Breitmaier,; Schneider, (1997)
      Acaena splendens H. et A., Rosacene, has been used in Chilean traditional medicine for the treatment of fever and inflammation. The antipyretic and antiinflammatory properties of the infusion, methanol, petroleum ether and ...
    • Arrau, Sylvia; Delporte Vergara, Carla; Cartagena, Carlos; Rodríguez Díaz, Maité; González, Patricia; Silva, Ximena; Cassels Niven, Bruce; Miranda Guzmán, Hugo (Elsevier, 2011-01-07)
      Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine. Aim of the study: The ...
    • Speisky Cosoy, Hernán; Cassels Niven, Bruce; Lissi Gervaso, Eduardo A.; Videla Cabrera, Luis (1991)
      Boldine, in low micromolar concentrations, was able to prevent brain homogenate autooxidation, the 2,2'-azobis(2-amidinopropane)(AAP)-induced lipid peroxidation of red cell plasma membranes, and the AAP-induced inactivation ...
    • Speisky Cosoy, Hernán; Cassels Niven, Bruce; Lissi Gervaso, Eduardo A.; Videla Cabrera, Luis (Pergamon Press, 1990-11-30)
      Boldine, in low micromolar concentrations, was able to prevent brain bomogenate autooxidatíon, the 2,2'·uobis(2·amidinopropane)(AAP)·induced Iipid peroxidation of red cell plasma rnembranes, and the AAP·induced inactivation ...
    • Suárez Rozas, Cristian; Simpson, Sebastián; Fuentes Retamal, Sebastián; Catalán, Mabel; Ferreira, Jorge; Theoduloz, Cristina; Mella, Jaime; Cabezas, David; Cassels Niven, Bruce; Yáñez, Claudia; Castro Castillo, Vicente (Elsevier Ltd, 2019)
      © 2018 1,4-Naphthoquinone derivatives have been widely documented with regard to their biological properties, and particularly their anticancer activities. In the 9,10-anthraquinone family, aza-annulation involving one of ...
    • Delporte Vergara, Carla; Backhouse Erazo, Nadine; Negrete Córdova, Rosa; Salinas, P.; Rivas Rubio, Paula Andrea; Cassels Niven, Bruce; San Feliciano, Arturo (JOHN WILEY & SONS LTD, 1998-03)
      The acute toxicities of the global methanol extract of Solanum ligustrinum (Solanaceae) and the crude steroidal glycoalkaloids mixture were determined. The antipyretic, hypothermic and antiinflammatory activities of aqueous, ...
    • Delporte Vergara, Carla; Backhouse Erazo, Nadine; Negrete Córdova, Rosa; Salinas, P.; Rivas, P.; Cassels Niven, Bruce; San Feliciano, A. (John Wiley & Sons, Ltd., 1997-10-26)
      The acute toxicities of the global methanol extract of Solanum ligustrinum (Solanaceae) and the crude steroidal glycoalkaloids mixture were determined. The antipyretic, hypothermic and antiinflammatory activities of ...
    • Iturriaga-Vásquez, Patricio; Pérez, Edwin G.; Slater, E. Yvonne; Bermúdez, Isabel; Cassels Niven, Bruce (2007)
      (S)-Aporphine metho salts with the 1,2,9, 10 oxygenation pattern displaced radioligands from recombinant human 0 and alpha 4 beta 2 neuronal nicotinic acetylcholine receptors (nAChR) at low micromolar concentrations. The ...
    • Sáez Briones, Patricio; Castro Castillo, Vicente; Díaz Véliz, Gabriela; Valladares Boasi, Luis; Barra, Rafael; Hernández, Alejandro; Cassels Niven, Bruce (Frontiers Media S.A., 2019)
      The entactogen MDMA (3,4-methylenedioxy-methamphetamine, “Ecstasy”) exerts its psychotropic effects acting primarily as a substrate of the serotonin transporter (SERT) to induce a non-exocytotic release of serotonin. ...
    • Cavé, André; Ocquemiller, Reynaldh; Cassels Niven, Bruce; Leboeuf, Michel; Rasamizafy, Sabino; Roblot, François; Davoust, Daniel; Deverre, J. R.; Khan, K. C.; Hadi, A. H. A. (American Chemical Society, 1985-11-25)
      The stem bark of Artabottys venustus yielded 0.34% of crude bases, mostly known aporphinoids and berbinoids. One of the minor constituents, (-)-artavenustine (12), is a new member of the rare class of catecholic isoquinoline ...
    • Arango, Gabriel; Corte, Diego; Cassels Niven, Bruce; Cavé, André; Mérienne, Claude (Pergamon Journals LId, 1986-11-11)
      The stem bark of Oxandra ef. major, whieh eontains large amounts of 7,7'-bisdehydroaporphine alkaloids, has also yielded three eommonplaee steroids, retieuline, four known aporphinoids and the new azafluorenones darienine, ...
    • Cassels Niven, Bruce; Cavé, André; Davoust, Daniel; Hocquemiller, Reynald; Rasamizafy, Sabino; Tadié, Dragana (Chemical Society, 1986-05-13)
      The structure elucidation of dragabine (1) and nordragabine (2), the first derivatives of the novel azahomoaporphine skeleton, isolated from Guatteria sagotiana and Meiogyne virgata (Ann¡onaceae), is reported.
    • Quinteros Muñoz, David; Sáez Briones, Patricio; Díaz Véliz, Emma; Mora Gutiérrez, Sergio; Rebolledo Fuentes, Marco; Cassels Niven, Bruce (AMER PSYCHOLOGICAL ASSOC, 2010-06-30)
      3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) is a psychoactive drug structurally related to other phenylisopropylamines acting as stimulants or hallucinogens in humans. Although MDMA has a pharmacological identity ...
    • Asencio, M.; Delaquerrière, B.; Cassels Niven, Bruce; Speisky Cosoy, Hernán; Comoy, E.; Protais, P. (1999)
      The aporphine alkaloids boldine and glaucine have been reported to show 'neuroleptic-like' actions in mice, suggesting that they may act as dopamine antagonists. We have found that in vitro boldine displaces specific ...