Browsing by Author "Chiong Lay, Mario"

Now showing items 61-80 of 123

    • Interactions between ß 1 and ß 2 adrenergic receptor polymorphisms as risk factors for chronic heart failure ... 
      Moraga, Francisco; Troncoso, Rodrigo; Mellado, Rosemarie; Díaz Araya, Guillermo; Vukasovic, José Luis; Greig, Douglas; Pérez, Osvaldo; García Nannig, Lorena; Roldán, Juan; Ocaranza, María Paz; Jalil Milad, Jorge; Chiong Lay, Mario; Castro, Pablo (2008)
      Background: ß adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostasis. Among these, ß1 and ß2 AR regulate cardiac contractility and frequency and are important pharmacological ...
    • Interleuquina 6 induce desdiferenciación de línea celular de musculo liso vascular 
      Hernández Díaz, Tomás Alonso (Universidad de Chile, 2019)
      Las células de músculo liso vascular (CMLV) son el principal componente de la túnica media en las arterias. Poseen una gran plasticidad fenotípica pasando de un estado diferenciado a desdiferenciado. Las CMLV desdiferenciadas ...
    • Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide 
      Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Toro, Barbra; Pedrozo Cibils, Zully; Díaz Elizondo, Jessica; Salas, Daniela; Parra Ortíz, María Valentina; Núñez González, Marco; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2010-02-15)
      We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...
    • Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial ... 
      Ocaranza, María Paz; Díaz Araya, Guillermo; Chiong Lay, Mario; Muñoz, David; Riveros, Juan Pablo; Ebensperger González, Roberto; Sabat, Sebastián; Irarrázabal, Pablo; Jalil Milad, Jorge; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2002-08)
      This study investigated whether long-term administration of isoproterenol (ISO) induces differential expression of angiotensin-converting enzyme (ACE) in lung, plasma, and left ventricle (LV) during development of left ...
    • La actividad de metaloproteinasa-9 se asocia al estrés oxidativo en el síndrome coronario agudo 
      Bittner, Alex; Castro Gálvez, Pablo; Pérez, Osvaldo; Corbalán, Ramón; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo Hernán; Chiong Lay, Mario; Díaz Araya, Guillermo; Vicencio, José Miguel; Moraga, Francisco; Zanolli, Diego; Winter, José L.; Zamorano, Juan J.; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      La metaloproteinasa (MMPs) son enzimas proteolíticas que participan en la inestabilidad de la placa aterosclerótica. En cultivos celulares, la actividad de metaloproteinasas-2 y 9 (MMP-2 y MMP-9) aumenta en presencia de ...
    • Local Control of Nuclear Calcium Signaling in Cardiac Myocytes by Perinuclear Microdomains of Sarcolemmal ... 
      Ibarra, Cristián; Vicencio, José M.; Estrada Hormazábal, Manuel; Lin, Yingbo; Rocco, Paola; Rebellato, Paola; Muñoz, Juan P.; García Prieto, Jaime; Quest, Andrew F. G.; Chiong Lay, Mario; Davidson, Sean M.; Bulatovic, Ivana; Grinnemo, Karl Henrik; Larsson, Olle; Szabadkai, Gyorgy; Uhlén, Per; Jaimovich Pérez, Enrique; Lavandero González, Sergio (American Heart Association, 2013)
      Rationale: The ability of a cell to independently regulate nuclear and cytosolic Ca2+ signaling is currently attributed to the differential distribution of inositol 1,4,5-trisphosphate receptor channel isoforms in the ...
    • Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure 
      Ocaranza, María Paz; Gabrielli, Luigi; Mora, Italo; García Nannig, Lorena; McNab, Paul; Godoy, Iván; Braun, Sandra; Córdova, Samuel; Castro, Pablo; Novoa, Ulises; Chiong Lay, Mario; Lavandero González, Sergio; Jalil, E. (MOSBY-ELSEVIER, 2011-05)
      Background The small guanosine triphosphatase Rho and its target Rho-kinase have significant roles in experimental remodeling and ventricular dysfunction, but no data are available on Rho-kinase activation in patients with ...
    • Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome 
      Bittner, Alex; Alcaíno Gálvez, Hernán Alejandro; Castro, Pablo F.; Pérez, Osvaldo; Corbalán, Ramón; Troncoso, Rodrigo; Chiong Lay, Mario; Mellado, Rosemarie; Moraga, Francisco; Zanolli, Diego; Winter, José L.; Zamorano, Juan J.; Díaz Araya, Guillermo; Lavandero González, Sergio (2010)
    • Mecanismos moleculares en la apoptosis del cardiomiocito y sus proyecciones patológicas y terapéuticas 
      Maldonado, Carola; Eisner, Verónica; Gálvez, Anita; Ulloa Valenzuela, Juan Alberto; Criollo Céspedes, Alfredo; Ocaranza Osses, Paula; Eltit Ortega, José Miguel; Morales, María Paz; Quiroga Lagos, Clara; Campos Bastidas, Ximena; Chiong Lay, Mario; Sapag Hagar, Mario; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2001)
      La apoptosis junto a la paraptosis y la necrosis constituyen las principales formas de muerte celular conocidas hasta la fecha. La apoptosis se caracteriza por una disminución del volumen celular y formación de "cuerpos ...
    • Mechanisms of cell death: molecular insights and therapeutic perspectives 
      Díaz Cuevas, Laín; Chiong Lay, Mario; Quest, Andrew F. G.; Lavandero González, Sergio; Stutzin Schottlander, Andrés (NATURE PUBLISHING GROUP, 2005-11)
      Editorial Material
    • Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a G ... 
      Eltit Ortega, José Miguel; García, Alejandra; Hidalgo Tapia, Jorge; Liberona Leppe, José; Chiong Lay, Mario; Lavandero González, Sergio; Maldonado Maldonado, Edio; Jaimovich Pérez, Enrique (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2006-04-28)
      Tetanic electrical stimulation of myotubes evokes a ryanodine receptor-related fast calcium signal, during the stimulation, followed by a phospholipase C/inositol 1,4,5-trisphosphate-dependent slow calcium signal few seconds ...
    • Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a ... 
      Eltit Ortega, José Miguel; García, Alejandra; Hidalgo, Jorge; Liberona, José L.; Chiong Lay, Mario; Lavandero González, Sergio; Maldonado, Edio; Jaimovich Pérez, Enrique (American Society for Biochemistry and Molecular Biology Inc., 2006)
      Tetanic electrical stimulation of myotubes evokes a ryanodine receptor-related fast calcium signal, during the stimulation, followed by a phospholipase C/inositol 1,4,5-trisphosphate-dependent slow calcium signal few seconds ...
    • Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca 
      Castro, Pablo; Gabrielli, Luigi A.; Verdejo, Hugo; Greig, Douglas; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda Morales, Luis; Vukasovic Ramírez, José Luis; García Nannig, Lorena; Pizarro, Marcela; Pivet, Deisy; Carrillo, Constanza; Tapia, Fabiola; Navarro, Mario; Troncoso, Rodrigo; Baraona, Fernando; Llevaneras, Silvana; Hernández, Claudia; Godoy, Iván; Jalil Milad, Jorge; Quintana, Juan Carlos; Orellana, Pilar; Chiong Lay, Mario; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2010-08)
      It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the ...
    • Mitochondrial dynamics: A potential new therapeutic target for heart failure Dinámica mitocondrial: un ... 
      Kuzmicic, Jovan; Del Campo, Andrea; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Bravo Sagua, Roberto; Hechenleitner, Jonathan; Zepeda, Ramiro; Castro, Pablo F.; Verdejo, Hugo; Parra, Valentina; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. ...
    • Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway 
      Pennanen, Christian; Parra, Valentina; López Crisosto, Camila; Morales, Pablo E.; del Campo, Andrea; Gutierrez, Tomás; Rivera Mejías, Pablo; Kuzmicic, Jovan; Chiong Lay, Mario; Zorzano, Antonio; Rothermel, Beverly A.; Lavandero González, Sergio (Company of Biologists Ltd, 2014)
      Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism. Mitochondria are crucial organelles for the production of ATP, and their morphology and function are regulated by the dynamic processes ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through ... 
      Campo Sfeir, Andrea Estefanía del; Parra Ortíz, María Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (American Physiological Society, 2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through ... 
      Del Campo, Andrea; Parra, Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Molecular mechanisms of autophagy in the cardiovascular system 
      Gatica, Damián; Chiong Lay, Mario; Lavandero González, Sergio; Klionsky, Daniel J. (Lippincott Williams and Wilkins, 2015)
      Autophagy is a catabolic recycling pathway triggered by various intra- or extracellular stimuli that is conserved from yeast to mammals. During autophagy diverse cytosolic constituents are enveloped by double-membrane ...
    • Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure ... 
      Winter, José Luis; Castro, Pablo; Meneses, Luis; Chalhub, Mónica; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Chiong Lay, Mario; Concepción, Roberto; Mellado, Rosemarie; Hernández, Claudia; Uribe, Sergio; Lavandero González, Sergio (2010)
      Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by ...
    • Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with αvβ3 ... 
      Avalos, Ana María; Valdivia, Alejandra D.; Muñoz, Nicolás; Herrera Molina, Rodrigo; Tapia, Julio C.; Lavandero González, Sergio; Chiong Lay, Mario; Burridge, Keith; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2009)
      Clustering of αvβ3 integrin after interaction with the RGD-like integrin-binding sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation. A putative ...