Now showing items 81-100 of 318

    • Cortés Albayay, Carlos Javier (Universidad de Chile, 2019)
      Durante la ultima década, el Desierto de Atacama se ha convertido en uno de los mas estudiados biomas de la extremobiósfera para la bioprospección microbiana enfocada en nuevas especies de actinobacterias. Muchos de estos ...
    • Cassels Niven, Bruce; Breitmaier, Eberhard; Zenk, Meinhart H. (Pergamon Journals Ltd., 1986-07-08)
      Callus cultures of 34 Berberís celllines representing 33 species were screened for alkaloids using TLC and HPLC. Jatrorrhizine was always found to be a major constituent; two B. stolonifera lines were the richest ...
    • Cassels Niven, Bruce; Urzúa, Alejandro (American Chemical Society, 1985-01-21)
      The stem bark of Laurelia sempervirens R. et P. (Monimiaceae, subfamily Atherospermoideae) is a rich source of aporphinoids and has also been shown to contain a complex mixture of unidentified bisbenzylisoquinolines (1). ...
    • Stadler, Richard; Loeffler, Susane; Cassels Niven, Bruce; Zenk, Meinhart H. (Pergamon Press plc., 1988-01-27)
      Bisbenzylisoquinoline alkaloid-producing cell cultures of Berberis stolonifera were fed with 14C-Iabelled tyrosine, tyramine, and several chiral l-benzyl-l,2,3,4-tetrahydroisoquinolines. Berbamunine subsequently isolated from ...
    • Cafferatta Chea, Emilio; Castro Saavedra, Sebastián; Fuentes Barros, Gonzalo; Melgar Rodríguez, Samanta; Rivera Rodríguez, Felipe; Carvajal Pavez, Paola; Hernández Ríos, Emma; Cortés, Bastián; Cortez, Cristian; Cassels Niven, Bruce; Vernal Astudillo, Rolando (Wiley, 2020)
      Background During periodontitis, tooth-supporting alveolar bone is resorbed when there is an increased expression of the pro-osteolytic factor termed receptor activator of nuclear factor kappa B ligand (RANKL), which is ...
    • Speisky Cosoy, Hernán; Cassels Niven, Bruce (The Italian Pharmacological Society, 1993-06-02)
      Boldo (Peumus boldus Mol.), a Chilean tree traditionally employed in folk medicine and recognized as a herbal remedy in a number of pharmacopoeias, mainly for the treatment of liver ailments, has recently been the subject ...
    • Speisky Cosoy, Hernán; Cassels Niven, Bruce (1994)
      Boldo (Peumus boldus Mol.), a Chilean tree traditionally employed in folk medicine and recognized as a herbal remedy in a number of pharmacopoeias, mainly for the treatment of liver ailments, has recently been the subject ...
    • Abin Carriquiry, Juan Andrés; Voutilainen, Merja H.; Barik, Jacques; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio; Bermúdez, Isabel; Durand, Claudia; Dajas, Federico; Wonnacott, Susan (ELSEVIER, 2006)
      Neuronal nicotinic acetylcholine receptors subserve predominantly modulatory roles in the brain, making them attractive therapeutic targets. Natural products provide key leads in the quest for nicotinic receptor subtype-selective ...
    • Cortés, M.; Garbarino, J. A.; Cassels Niven, Bruce (ELSEVIER, 1971-07-30)
      Trichocereus chilensis (Colla) Br. & R. is the only Chilean member of its genus figuring in the literature as having been examined for alkaloids, although previous reports are negative. Djerassi and coworkers1 found no ...
    • Fajardo, Víctor; Garrido, Margarita; Cassels Niven, Bruce (ELSEVIER, 1980-10-13)
      A new bisbenzylisoquinoline alkaloid fran Berberis buxifolia was chemically correlated with ealafatine. On this basis, and using spectranetric evidence, structure 1is proposed for ealafatirnine. The stereochanistry ...
    • Fajardo, V.; Urzúa, A.; Cassels Niven, Bruce (Universidad Técnica del Estado, 1978-11)
      La calafatina es un componente importante de las mezclas de alcaloides no cuaternarios de la corteza de tronco y de las raiees de Berberis buxifolia Lam. ("calafate"). Sobre la base de estudios espectrométricos de esta ...
    • Fajardo, Víctor; Urzúa, Alejandro; Cassels Niven, Bruce (ELSEVIER, 1979-09-26)
      Spectrometric and chemical evidence is presented that calafatine, an alkaloid from Berberis buxifolia, has structure l. The substitution pattern on ring E is unique ln isoquinoline alkaloids.
    • Goïty Vivar, León Eduardo (Universidad de Chile, 2013)
      En esta tesis se observó que los extractos seriados de acetato de etilo (EAE) y etanol (EET) de las hojas de Ugni molinae Turcz. (murtilla) son fuente de los ácidos, asiático, alfitólico, corosólico, betulínico, oleanólico, ...
    • Morales, M. A.; Bustamante, S. E.; Brito, G.; Paz, D.; Cassels Niven, Bruce (John Wiley & Sons, Ltd., 1997-10-09)
      Tbe cardiovascular etTeets of (±)-norannepavine, a benzylisoquinoline alkaloid of natural origin, have been detennined on anaesthetized rats in vivo, on spontaneously beating atria and on aortic smooth muscle. In aorta, ...
    • Sobarzo Sánchez, Eduardo; Olea Azar, Claudio; Alarcón, Jaime; Opazo, Lucía; Cassels Niven, Bruce (2003)
      The electrochemical behavior of two representative 2,3-dihydro-7H-dibenzo[de,h]quinolin-7-ones was determined using cyclic voltammetry in DMSO as solvent and rationalized by quantum chemical calculations using ab initio ...
    • Squella Serrano, Juan; Pezzani, M.; Cassels Niven, Bruce; Aillón Torres, Milton; Rezende, Marcos; Núñez Vergara, Luis (1992)
      The amphetamine derivative 4,5‐dimethoxy‐2‐nitrophenyl‐2‐aminopropane, a positional isomer of the potent hallucinogen DON, was studied by cyclic voltammetry and polarography. The nitro compound was reduced to the corresponding ...
    • Mazariegos, Dora Inés; Cabantchik, Z. Ioav; Cassels Niven, Bruce; Núñez González, Marco (2006)
      There is increasing evidence that accumulation of redox-active iron in mitochondria leads to oxidative damage and contributes to various neurodegenerative diseases, such as Friedreich’s ataxia and Parkinson’s disease. ...
    • Vallejos, Gabriel; Caroli Rezende, Marcos; Cassels Niven, Bruce (Kluwer Academic Publishers, 2002-03-05)
      The HOMO energies and the charges on the aromatic carbons of two sets of MAO-A-inhibiting phenylisopropylamines, one containing 4-amino substituents, were calculated by the AM1 method, in order to evaluate the importance ...
    • Fajardo, Víctor; Elango, Varadaraj; Cassels Niven, Bruce; Shamma, Maurice (Pergamon Press Ltd., 1981-09-24)
      If)-Chilenine (3), the first isoindolobenzazepine alkaloid, has been fou& in Berberis enpetrifolia Lam. IBerberidaceae).
    • Fajardo, Víctor; Elango, Varadaraj; Cassels Niven, Bruce; Shamma, Maurice (Pergarnon Press Ltd., 1981-09-24)
      (i:)-ChiZenine (3), the first isoindolobenaaaepine atkatoid, has been found in BerbeX'is empem[otia Lam. (Berberidaoeae).