Browsing by Author "201-0300879"
Now showing items 21-40 of 66
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(2013-11)ATP signaling has been shown to regulate gene expression in skeletal muscle and to be altered in models of muscular dystrophy. We have previously shown that in normal muscle fibers, ATP released through Pannexin1 (Panx1) ...
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(American Diabetes Association, 2013)Skeletal muscle glucose uptake in response to exercise is preserved in insulin-resistant conditions, but the signals involved are debated. ATP is released from skeletal muscle by contractile activity and can autocrinely ...
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(Chapman Hall, 1997)An immortal, cloned cell Line (RCMH), obtained from human skeletal muscle was established in our laboratory and shown to express muscle specific proteins. We measured ligand binding to ion channels, ion currents using whole ...
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(Bioscientifica, 2020)Fibroblast growth factor 21 (FGF21) is a pleiotropic peptide hormone that is considered a myokine playing a role in a variety of endocrine functions, including regulation of glucose transport and lipid metabolism. Although ...
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(Elsevier, 2016)Homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 1 (HERPUD1), an ER resident protein, is upregulated in response to ER stress and Ca2(+) homeostasis deregulation. HERPUD1 ...
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(Wiley Periodicals, 2013)Skeletal muscle differentiation is a complex and highly regulated process characterized by cell cycle arrest, which is associated with morphological changes including myoblast alignment, elongation, and fusion into ...
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(SOC ENDOCRINOLOGY, 2004-08)We studied the effect of IGF-I and insulin on intracellular Ca2+ in primary cultured myotubes. IGF-I induced a fast and transient Ca2+ increase, measured as fluo-3 fluorescence. This response was blocked by both genistein ...
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(ENDOCRINE SOC, 2010-10)Intracellular calcium levels ([Ca2+](i)) and glucose uptake are central to cardiomyocyte physiology, yet connections between them have not been studied. We investigated whether insulin regulates [Ca2+](i) in cultured ...
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(The Company of Biologists Ltd, 2014)Insulin signaling includes generation of low levels of H2O2; however, its origin and contribution to insulin-stimulated glucose transport are unknown. We tested the impact of H2O2 on insulin-dependent glucose transport ...
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(Amer Biochemistry Molecular Biology, 2004-02-27)In the heart, insulin-like growth factor-1 (IGF-1) is a pro-hypertrophic and anti-apoptotic peptide. In cultured rat cardiomyocytes, IGF-1 induced a fast and transient increase in Ca-i(2+) levels apparent both in the nucleus ...
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(Universidad de Chile, 2007)Insulina y su receptor (RI) regulan el metabolismo de ácidos grasos y carbohidratos en el corazón. La activación de este receptor por su ligando endógeno desencadena una serie de eventos reguladores de la homeostasis energética ...
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(Elsevier B.V., 2017)© 2016 Elsevier B.V. Duchenne muscular dystrophy (DMD) is a neuromuscular disease originated by mutations in the dystrophin gene. A promising therapeutic approach deals with functional substitution of dystrophin by utrophin, ...
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(1994)Cultured myotubes from rat neonatal skeletal muscle were used to measure intracellular Ca2+ concentration ([Ca2ri) and membrane potentials (Vm) uslng the Indo-l mlcrofluorimetry method and the nystatin perforated membrane ...
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(John Wiley and Sons, 1994)A cell line (RCDMD), derived from a muscle biopsy taken from a 7-year-old patient with Duchenne muscular dystrophy (DMD), was established in vitro using conditioned media from the UCHT1 thyroid cell line as described ...
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(Elsevier, 1986)The presence of four cation pathways in membrane vesicles isolated from transverse tubules of frog and rabbit skeletal muscle was studied by measuring binding of specific blockers. Transverse tubules purified from frog ...
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(Amer Physiological Soc, 2000)Inositol 1,4,5-trisphosphate (IP3) receptors (IP3R) and ryanodine receptors (RyR) were localized in cultured rodent muscle fractions by binding of radiolabeled ligands (IP3 and ryanodine), and IP3R were visualized in situ ...
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(American Heart Association, 2013)Rationale: The ability of a cell to independently regulate nuclear and cytosolic Ca2+ signaling is currently attributed to the differential distribution of inositol 1,4,5-trisphosphate receptor channel isoforms in the ...
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(Frontiers Media, 2015)Nuclear Ca2+ is important for the regulation of several nuclear processes such as gene expression. Localized Ca2+ signals (LCSs) in skeletal muscle fibers of mice have been mainly studied as Ca2+ release events from the ...
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(2001)1. The gating kinetics and functions of low threshold T-type current in cultured chromaffin cells from rats of 19-20 days gestation (E19-E20) were studied using the patch clamp technique. Exocytosis induced by calcium ...
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(Universidad de ChileCyberDocs, 2010)Tanto los niveles intracelulares de Ca2+ ([Ca2+]i) como el transporte de la glucosa son fundamentales para la fisiología del cardiomiocito, sin embargo, aún no se ha investigado la interrelación entre ambos eventos. En ...
