Browsing by Author "23f57078-d452-4efb-a783-f09fea58f52d"

Now showing items 21-32 of 32

    • Phenolic composition and antioxidant capacity of Ugni molinae Turcz. leaves of different genotypes 
      Peña Cerda, Marcelo Edgardo; Arancibia Radich, Jorge; Valenzuela Bustamante, Paula; Pérez Arancibia, Rodrigo Nicolás; Barriga, Andrés; Seguel, Ivette; García Nannig, Lorena; Delporte, Carla (Elsevier Ltd, 2017)
      © 2016 Elsevier Ltd Ugni molinae Turcz. is a native shrub of Chile, known for its edible berries and its leaves, which have been the focus of recent attention, as a good source of phenolic compounds to be used in cosmetics ...
    • Preoperative soluble VCAM-1 contributes to predict late mortality after coronary artery surgery 
      Corbalán, Ramón; García, Mauricio; Garrido Olivares, Luis; García Nannig, Lorena; Pérez, Gonzalo; Mellado, Rosemarie; Zalaquett, Ricardo; Chiong, Mario; Quitral, Jorge; Lavandero González, Sergio (Wiley, 2020)
      Background Soluble vascular cell adhesion molecule-1 has been associated with long-term cardiovascular mortality in patients with stable coronary artery disease and to the development of new atrial fibrillation in subjects ...
    • Pro-fibrotic effect of oxidized LDL in cardiac myofibroblasts 
      Villa, Mónica; Cerda Opazo, Paulina; Jiménez Gallegos, Danica; Garrido Moreno, Valeria; Chiong Lay, Mario; Quest, Andrew F. G.; Toledo, Jorge; García Nannig, Lorena (Elsevier, 2020)
      Inflammatory signals associated with cardiac diseases trigger trans-differentiation of cardiac fibroblasts to cardiac myofibroblasts. Cardiac myofibroblasts are the main cell type involved in the development of cardiac ...
    • Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2 
      Ocaranza, María Paz; Valderas, Patricio; Moya, Jackeline; Gabrielli, Luigi; Godoy, Iván; Córdava, Samuel; Mac Nab, Paul; García Nannig, Lorena; Farías, Luis; Jalil, Jorge E. (BMC, 2020)
      BackgroundThe intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. Besides, in preclinical models of diabetes, ...
    • Sodium intake is associated with endothelial damage biomarkers and metabolic dysregulation 
      Campino, Carmen; Baudrand, Rene; Valdivia, Carolina; Carvajal, Cristian; Vecchiola, Andrea; Tapia Castillo, Alejandra; Martínez Aguayo, Alejandro; Garcia, Hernán; García Nannig, Lorena; Allende, Fidel; Solari, Sandra; Fuentes, Cristóbal; Lagos, Carlos; Rojas, Maria; Muñoz, Doris; Fardella, Carlos E. (Oxford University Press, 2018)
      BACKGROUND : Mounting evidence has associated high sodium (HS) intake with hypertension, cardiovascular disease, and stroke. We investigated whether HS intake modulates the parameters of endothelial damage, inflammation, ...
    • Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate ... 
      del Campo, Miguel; Zhong, Ta- Ying; Tampe, Ricardo; García Nannig, Lorena; Lagos, Néstor (Elsevier Ltd, 2017)
      © 2016 Elsevier LtdOne of the proposed mechanisms to explain why Diarrhetic Shellfish Poison (DSP) toxins are tumor promoters is founded on the capacity of these toxins to increase TNF-α secretion. Although macrophages are ...
    • Systemic vascular cell adhesion molecule-1 predicts the occurrence of post-operative atrial fibrillation 
      Verdejo, Hugo; Roldán, Juan; García Nannig, Lorena; Del Campo, Andrea; Becerra, Elia; Chiong Lay, Mario; Mellado, Rosemarie; Garcia, Amalia; Zalaquett Sepúlveda, Ricardo; Braun, Sandra; Garayar, Bernardita; Gonzalez, Sergio; Lavandero González, Sergio; Corbalán, Ramón (2011)
      Background: Post-operative atrial fibrillation occurs in 30% of patients after on-pump heart surgery and is associated to elevated inflammatory markers. We have evaluated if the systemic biomarkers of inflammation and ...
    • TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both ... 
      Vivar, Raúl; Humeres, Claudio; Ayala, Pedro; Olmedo, Ivonne; Catalán, Mabel; García Nannig, Lorena; Lavandero González, Sergio; Díaz Araya, Guillermo (2013)
      Ischemia/reperfusion injury is a major cause of myocardial death. In the heart, cardiac fibroblasts play a critical role in healing post myocardial infarction. TGF-β1 has shown cardioprotective effects in cardiac damage; ...
    • The role of uric acid in heart failure Ácido úrico: Una molécula con acciones paradójicas en la insuficiencia ... 
      Alcaíno Gálvez, Hernán Alejandro; Greig, Douglas; Castro, Pablo; Verdejo, Hugo; Mellado, Rosemarie; García Nannig, Lorena; Díaz Araya, Guillermo; Quiroga, Clara; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart ...
    • The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content 
      Shaikh, S.; Troncoso Cotal, Rodrigo; Mondaca Ruff, David; Parra Ortíz, María Valentina; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio (Elsevier, 2018)
      Stromal-interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) plays a key role in mediating cardiomyocyte hypertrophy, both in vitro and in vivo. Moreover, there is growing support for the contribution ...
    • Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes 
      Kuzmicic Previtali, Jovan Paolo; Parra, Valentina; Verdejo, Hugo E.; López Crisosto, Camila; Chiong Lay, Mario; García Nannig, Lorena; Jensen, Michael D.; Bernlohr, David A.; Castro, Pablo F.; Lavandero González, Sergio (Elsevier Inc., 2014)
      © 2014 Elsevier Inc. All rights reserved. Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), ...
    • Trophic factors in cerebrospinal fluid and spinal cord of patients with tropical spastic paraparesis, HIV, ... 
      Albrecht, David; García Nannig, Lorena; Cartier Rovirosa, Luis; Kettlun, Ana M.; Vergara, Carmen; Collados, Lucia; Valenzuela, M. Antonieta (2006)
      HTLV-1-associated myelopathy/tropical spastic paraparesis (TSP/HAM) is a chronic CNS disease characterized by axomyelinic degeneration of the long axons of corticospinal tracts. Levels of NGF, NT-3, NT-4/5, BDNF, GDNF, ...