Now showing items 21-28 of 28

    • Hidalgo Tapia, María Cecilia; Aracena, Paula; Sánchez, Gina; Donoso Laurent, Paulina (Society of Biology of Chile, 2002)
      In skeletal and cardiac muscle cells, specific isoforms of the Ryanodine receptor channels mediate Ca2+ release from the sarcoplasmic reticulum. These channels are highly susceptible to redox modifications, which regulate ...
    • Becerra, Romina; Román, Bárbara; Di Carlo, Mariano; Mariangelo, Juan Ignacio; Salas, Margarita; Sánchez, Gina; Donoso Laurent, Paulina; Schinella, Guillermo; Vittone, Leticia; Wehrens, Xander; Mundiña Weilenmann, Cecilia; Said, Matilde (American Physiological Society, 2016)
      Previous results from our laboratory showed that phosphorylation of ryanodine receptor 2 (RyR2) by Ca2+ calmodulin-dependent kinase II (CaMKII) was a critical but not the unique event responsible for the production of ...
    • Aracena Parks, Paula; Sánchez, Gina; Donoso Laurent, Paulina; Hamilton, Susan L.; Hidalgo Tapia, María Cecilia (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-31)
      We have analyzed the effects of the endogenous redoxactive agents S-nitrosoglutathione and glutathione disulfide, and the NO donor NOR-3, on calcium release kinetics mediated by ryanodine receptor channels. Incubation of ...
    • Hidalgo Tapia, María Cecilia; Bull Simpfendorfer, Ricardo; Marengo, Juan J.; Perez, Claudio F.; Donoso Laurent, Paulina (Society of Biology of Chile, 2000)
      The effects of redox reagents on the activity of the intracellular calcium release channels (ryanodine receptors) of skeletal and cardiac muscle, or brain cortex neurons, was examined. In lipid bilayer experiments, oxidizing ...
    • Donoso Laurent, Paulina; Hidalgo Tapia, María Cecilia (1989)
      Transverse tubule vesicles isolated from frog skeletal muscle display sodium-calcium exchange activity, which was characterized measuring 45Ca influx in vesicles incubated with sodium. The initial rates of exchange varied ...
    • Donoso Laurent, Paulina; Finkelstein Muñoz, José Pablo; Montecinos, Luis; Said, Matilde; Sánchez, Gina; Vittone, Leticia; Bull Simpfendorfer, Ricardo (Elsevier, 2014)
      The response of ryanodine receptor (RyR) channels to cytoplasmic free calcium concentration ([Ca2+]) is redox sensitive. Here, we report the effects of a mild oxidative stress on cardiac RyR (RyR2) channels in ...
    • Sánchez, Gina; Pedrozo Cibils, Zully; Domenech Lira, Raúl; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2005-12)
      We have shown previously that electrically induced tachycardia effectively produces myocardial preconditioning. Among other effects, tachycardia increases calcium release rates in microsomal fractions enriched in sarcoplasmic ...
    • Oyarzún, Manuel J.; Donoso Laurent, Paulina; Arias, Mónica; Quijada, Dolly (1984)
      Intravenous infusion of free fatty acid (FFA) produces pulmonary edema and an increase in the alveolar surfactant content of the rabbit. In order to identify a likely mediator of this lung response to FFA, we used inhibitors ...