Browsing by Author "b3ecc49b-9aea-4927-9954-2dedb32617fc"

Now showing items 21-29 of 29

    • MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells 
      Villablanca, Eduardo J.; Wang, Sen; De Calisto, Jaime; Gomes, Daniel C.O.; Kane, Maureen A.; Napoli, Joseph L.; Blaner, William S.; Kagechika, Hiroyuki; Blomhoff, Rune; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Von Andrian, Ulrich H.; Mora, J. Rodrigo (W.B. Saunders, 2011)
      Background & Aims: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation ...
    • Notch Signalling Regulates Cytokine Production by CD8+ and CD4+ T Cells 
      Sauma Mahaluf, Daniela; Ramirez, A.; Alvarez, K.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2012)
      The Notch signalling pathway regulates several aspects of cellular differentiation such as T lineage commitment and effector functions on peripheral T cells; however, there is limited information regarding Notch receptor ...
    • P2X7 receptor at the crossroads of T cell fate 
      Rivas Yáñez, Elizabeth; Barrera Ávalos, Carlos; Parra Tello, Brian; Briceño, Pedro F.; Rosemblatt, Mariana V.; Saavedra Almarza, Juan Pablo; Rosemblatt Silber, Mario; Acuña Castillo, Claudio; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (MDPI, 2020)
      The P2X7 receptor is a ligand-gated, cation-selective channel whose main physiological ligand is ATP. P2X7 receptor activation may also be triggered by ARTC2.2-dependent ADP ribosylation in the presence of extracellular ...
    • Retinoic Acid as a Modulator of T Cell Immunity 
      Bono Merino, María Rosa; Tejón, Gabriela; Flores Santibáñez, Felipe; Fernández, Dominique; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (MDPI, 2016)
      Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual ...
    • Retinoic acid generates regulatory T cells in experimental transplantation 
      Moore, C.; Fuentes C., Claudio; Sauma Mahaluf, Daniela; Morales, J.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Fierro, J. A. (2011)
      Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory ...
    • Role of PD-L2 in B lymphocytes during the development of lupus 
      Hidalgo, Y.; Fuenzalida, M. J.; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela; Bono Merino, María Rosa (2016)
    • Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing ... 
      Candia, Enzo; Reyes, Paz; Covian, Camila; Rodríguez, Francisco; Wainstein, Nicolás; Morales, Jorge; Mosso, Claudio; Rosemblatt Silber, Mario César; Fierro, Juan Alberto (Public Library Science, 2017)
      Adoptive transfer of CD4+CD25+FOXP3+ regulatory T cells (Treg cells) has been successfully utilized to treat graft versus host disease and represents a promising strategy for the treatment of autoimmune diseases and ...
    • The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype ... 
      Doñas, Cristian; Carrasco, Macarena; Fritz, Macarena; Ríos del Prado, Carolina Alejandra; Tejón, Gabriela; Osorio Barrios, Francisco; Manríquez, Valeria; Reyes, Paz; Pacheco, Rodrigo; Bono Merino, María Rosa; Loyola, Alejandra; Rosemblatt Silber, Mario César (Academic Press, 2016)
      © 2016 The Authors As it has been established that demethylation of lysine 27 of histone H3 by the lysine-specific demethylase JMJD3 increases immune responses and thus elicits inflammation, we hypothesize that inhibition ...
    • Transforming Growth Factor-β and All-Trans Retinoic Acid Generate Ex Vivo Transgenic Regulatory T Cells ... 
      Moore, C.; Sauma Mahaluf, Daniela; Morales, J.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Fierro, J. A. (2009)
      CD4+CD25+Foxp3+ regulatory T cells (Treg) mediate immunologic self-tolerance and suppress immune responses. In the gut, a subset of dendritic cells is specialized to induce Treg in a transforming growth factor-β (TGF-β)- ...