Browsing by Author "Saitz Barría, Claudio"
Now showing items 21-40 of 46
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Insuasty O, Braulio; Insuasty I, Henry; Quiroga P, Jairo; Saitz Barría, Claudio; Jullian Matthaei, Carolina (HeteroCorporation, 2000)Several new 6-amino- and 6,8-diamino-4-aryl-2,3-dihydropyrimido[4,5- b][1,4]diazepines were obtained from the reaction of 4,5,6-triaminopyrimidine 1a and 2,4,5,6-tetraaminopyrimidine 1b with one equivalent of 3- ...
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Insuasty, B.; Saitz Barría, Claudio; Insuasty, H.; Quiroga, J.; Jullian Matthaei, Carolina (HETERO CORPORATION, 2000-03)Several new 6-amino- and 6,8-dinmino-4-aryl-2,3-dihydropyrimido[4,5-b][1,4]diazepines were obtained from the reaction of 4,5,6-triaminopyrimidine 1a and 2,4,5,6-tetraaminopyrimidine 1b with one equivalent of 3-dimethylam ...
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Insuasty O, Braulio; Insuasty I, Henry; Quiroga P, Jairo; Saitz Barría, Claudio; Jullian Matthaei, Carolina (HeteroCorporation, 1999)New 4-Aryl-6-methyl-8-phenyl-2,3-dihydropyrazolo[3,4-b]diazepines and 4- aryl-8-methyl-6-phenyl-2,3-dihydropyrazolo[4,3-b]diazepines were obtained from the reaction of 4,5-diamino-3-methyl-1-phenylpyrazole 1 with one ...
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Insuasty, B.; Insuasty, H.; Saitz Barría, Claudio; Quiroga, J.; Jullian Matthaei, Carolina (HETERO CORPORATION, 1999-05)New 4-Aryl-6-methyl-8-phenyl-2,3-dihydropyrazolo[3,4-b]diazepines and 4-aryl-8-methyl-6-phenyl-2,3-dihydropyrazolo[4,3-b]diazepines were obtained from the reaction of 4,5-diamino-3-methyl-1-phenylpyrazole 1 with one ...
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Quiroga Campano, Cinthia del Rosario (Universidad de Chile, 2014)Los calixarenos son compuestos macrocíclicos preparados a partir de la condensación de fenoles sustituidos y aldehídos, los cuales pueden presentar diversas conformaciones y proporciona un gran número de cavidades únicas ...
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Síntesis de calix[4]arenos modificados en el upper y lower rim : estudios de complejación de iones Gómez Machuca, Horacio Exequiel (Universidad de Chile, 2014)Los calixarenos son moléculas macrocíclicas compuestas de unidades fenólicas, conectadas por puentes de metileno, que forman una cavidad hidrofóbica capaz de generar complejos de inclusión con una gran variedad de iones ...
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Pessoa Mahana, Hernán; Kosche Cárcamo, Johann; Ron Higuera, Nadia; Recabarren Gajardo, Gonzalo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Pessoa Mahana, Carlos (2008)A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene ...
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Pessoa Mahana, Hernán; González, Marcos; González, Marcelo; Pessoa Mahana, David; Araya Maturana, Ramiro; Ron, Nadia; Saitz Barría, Claudio (Arkat, 2009)A series of Michael adducts (5-11) have been synthesized with good yields under solvent-free microwave conditions. Aliphatic and aromatic amines utilized as Michael donors reacted with 1-(4,7-dimethoxybenzo[b]thiophen-2- ...
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Studies on quinones.209 a convenient approach to the synthesis of 2-acetonylpyranonaphuthoquinones Saitz Barría, Claudio; Valderrama Guerrero, Jaime Adolfo; Tapia, R. (MARCEL DEKKER INC, 1990)a SHORT AND EFFICIENT SYNTHESIS OF 2-ACETONYLPYRANONAPHTHOQUINONES (13 AND 14) STARTING FROM MICHAEL ADDUCT 5 IS DESCRIBED
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Quiroga Campano, Cinthia del Rosario; Gómez Machuca, Horacio Exequiel; Jullian Matthaei, Carolina; Fuente Urrutia, Julio de la; Pessoa Mahana, Hernán; Saitz Barría, Claudio (Springer, 2014)The present work describes a study of complexation efficiency and selectivity of calix[4]arenes bearing benzoimidazolyl, benzothiazolyl, and benzoxazolyl heterocycles (5–7) towards several selected metal ions ...
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Méndez-Rojas, Claudio; Quiroz, Gabriel; Faúndez, Mario; Gallardo Garrido, Carlos Andrés; Pessoa Mahana, Carlos David; Chung, Hery; Gallardo Toledo, Eduardo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Kogan Bocian, Marcelo; Zúñiga López, María C.; Iturriaga-Vásquez, Patricio; (Wiley-VCH Verlag, 2018)© 2018 Deutsche Pharmazeutische Gesellschaft With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated ...
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Pessoa Mahana, Hernán; Silva Matus, Paul Eduardo; Pessoa Mahana, Carlos David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata Torres, Gerald; Saitz Barría, Claudio; Araya Maturana, Ramiro; Reyes Parada, Miguel (Wiley, 2017)A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the ...
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Pessoa Mahana, Hernán; Cuevas M., Ignacio; Pessoa Mahana, Carlos David; Araya Maturana, Ramiro; Almodovar, Iriux; Saitz Barría, Claudio (2011)The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through ...
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Saitz Barría, Claudio; Valderrama Guerrero, Jaime Adolfo; Tapia, R.; Fariña, Francisco; Paredes, M. Carmen (MARCEL DEKKER INC, 1992)The synthesis of pyranoquinone 6 and its application to the elaboration of pyranonaphthoquinone 1b is described.
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Quiroga, J.; Insuasty, B.; Hormaza, Angela; Saitz Barría, Claudio; Jullian Matthaei, Carolina (HETERO CORPORATION, 1998-05)Reaction of 5-amino-3-methyl-1-phenylpyrazole (1a) and 5-amino-3-(4-chlorophenyl)-1H-pyrazole (1b) with dimedone (2) and p-susbstituted benzaldehydes 3 in ethanol, afforded in all cases tricyclic linear 4-aryl- ...
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Cañete Molina, Alvaro Félix; Meléndrez Cancino, Mónica Ximena; Saitz Barría, Claudio; Zanocco Loyola, Antonio (MARCEL DEKKER INC, 2001)A very simple and efficient method to prepare aminonaphthalene derivatives in good yield using the Bucherer reaction under microwave irradiation in a closed vessel is described. A reaction time of 30 min at 150 Watts of ...
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Pessoa Mahana, Hernán; Acevedo Ramos, Armando Rodrigo; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (TAYLOR & FRANCIS INC, 2007)New benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl] ...
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Torres Pinedo, Antonio; Santoyo González, Francisco; Saitz Barría, Claudio (GEORG THIEME VERLAG, 1999-12)The effective synthesis of a variety of bisthiourea-bridged calix[4]arenes substituted by carbohydrates units (D-glucose, D-mannose, D-galactose and lactose) at the narrow rim by reaction of bis(aminoethoxy)calix[4]arene ...
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Saitz Barría, Claudio; Fuente, J. de la; Jullian Matthaei, Carolina; Pessoa Mahana, Hernán; Olea, Carolina (SCIENCE REVIEWS LTD, 2008-06)A novel series of calix[4]arenes bearing benzothiazole, benzoxazole, and benzoimidazole groups were obtained by the reaction of the corresponding 2-mercaptoheterocycle with 5,11,17,23-tetra-tert-butyl-25,27-bis[2-(chloroacetamido) ...
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Quiroga, Jairo; Hormaza, Angelina; Insuasty, Braulio; Saitz Barría, Claudio; Jullian Matthaei, Carolina; Cañete, Alvaro (HeteroCorporation, 1998)A series of pyrazolo[1,5-a]pyrimidin-3-ones 3 was prepared from Meldrum's acid and 5-amino-3-arylpyrazoles 1 by cyclization in nitrobenzene of the corresponding 5-pyrazolylaminomethylene Meldrum's acid derivatives 2. The ...