Browsing by Author "1a297a98-4876-4a1f-8921-c55a9d1cad9e"

Now showing items 41-60 of 74

    • Helicobacter pylori Infection Is Associated with Decreased Expression of SLC5A8, a Cancer Suppressor Gene, ... 
      Orellana Manzano, Andrea; O'Ryan Gallardo, Miguel; Lagomarcino, Anne; George Carreño, Sergio; Muñoz, Mindy; Mamani Manzano, Nora; Serrano, Carolina; Harris, Paul; Ramilo, Octavio; Mejías, Asunción; Torres Torretti, Juan Pablo; Lucero Álvarez, Yalda; Quest, Andrew F. G. (Frontiers Media, 2016)
      Background: Helicobacter pylori infects half of the world's population and causes gastric cancer in a subset of infected adults. Previous blood microarray findings showed that apparently healthy children, persistently ...
    • Human survivin and trypanosoma cruzi calreticulin act in synergy against a murine melanoma in vivo 
      Aguilar Guzmán, Lorena Andrea; Lobos González, Lorena; Rosas, Carlos; Vallejos, Gerardo; Falcón, Cristián; Sosoniuk Roche, Eduardo Rodrigo; Coddou, Francisca; Leyton Campos, Lisette; Lemus Acuña, Luis; Quest, Andrew F. G.; Ferreira Vigouroux, Luis Arturo (2014)
      Immune-based anti-tumor or anti-angiogenic therapies hold considerable promise for the treatment of cancer. The first approach seeks to activate tumor antigen-specific T lymphocytes while, the second, delays tumor growth ...
    • Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis 
      Silva, Patricio; Mendoza, Pablo; Rivas, Solange; Díaz, Jorge; Moraga, Carolina; Quest, Andrew F. G.; Torres, V. A. (Oncotarget, 2016)
      Hypoxia, a common condition of the tumor microenvironment, is associated with poor patient prognosis, tumor cell migration, invasion and metastasis. Recent evidence suggests that hypoxia alters endosome dynamics in tumor ...
    • Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration 
      Álvarez, Álvaro; Lagos Cabré, Raúl; Kong, Milene; Cárdenas, Areli; Burgos Bravo, Francesca; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (Elsevier, 2016)
      Our previous reports indicate that ligand-induced alpha(v)beta(3) integrin and Syndecan-4 engagement increases focal adhesion formation and migration of astrocytes. Additionally, ligated integrins trigger ATP release through ...
    • Intradermal DNA electroporation induces survivin-speciWc CTLs, suppresses angiogenesis and confers protection ... 
      Lladser, Álvaro; Ljungberg, Karl; Tufvesson, Helena; Tazzari, Marcella; Roos, Anna-Karin; Quest, Andrew F. G.; Kiessling, Rolf (Springer-Verlag, 2010)
      Survivin is an intracellular tumor-associated antigen that is broadly expressed in a large variety of tumors and also in tumor associated endothelial cells but mostly absent in diVerentiated tissues. Naked DNA ...
    • Local Control of Nuclear Calcium Signaling in Cardiac Myocytes by Perinuclear Microdomains of Sarcolemmal ... 
      Ibarra, Cristián; Vicencio, José M.; Estrada Hormazábal, Manuel; Lin, Yingbo; Rocco, Paola; Rebellato, Paola; Muñoz, Juan P.; García Prieto, Jaime; Quest, Andrew F. G.; Chiong Lay, Mario; Davidson, Sean M.; Bulatovic, Ivana; Grinnemo, Karl Henrik; Larsson, Olle; Szabadkai, Gyorgy; Uhlén, Per; Jaimovich Pérez, Enrique; Lavandero González, Sergio (American Heart Association, 2013)
      Rationale: The ability of a cell to independently regulate nuclear and cytosolic Ca2+ signaling is currently attributed to the differential distribution of inositol 1,4,5-trisphosphate receptor channel isoforms in the ...
    • Loss of caveolin-1 is associated with a decrease in beta cell death in mice on a high fat diet 
      Lillo Urzúa, Paloma; Núñez Murillo, Olinda; Castro Sepúlveda, Mauricio; Torres Quintana, María Angélica; Lladser Caldera, Álvaro; Quest, Andrew F. G.; Espinoza Robles, Carolina; Llanos Vidal, Paola; Wehinger, Sergio (MDPI, 2020)
      Elevated free fatty acids (FFAs) impair beta cell function and reduce beta cell mass as a consequence of the lipotoxicity that occurs in type 2 diabetes (T2D). We previously reported that the membrane protein caveolin-1 ...
    • Mechanisms of cell death: molecular insights and therapeutic perspectives 
      Díaz Cuevas, Laín; Chiong Lay, Mario; Quest, Andrew F. G.; Lavandero González, Sergio; Stutzin Schottlander, Andrés (NATURE PUBLISHING GROUP, 2005-11)
      Editorial Material
    • Mechanotransduction and epigenetic control in autoimmune diseases 
      González, Sergio; Aguilera, Sergio; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Molina, Claudio; Alliende, Cecilia; Hermoso Ramello, Marcela; González Burgos, María Julieta (Elsevier, 2011)
      Differentiation of epithelial cells is required to define tissue architecture and appropriate function of these cells is associated with a specific pattern of gene expression. DNA methylation, post-translational modification ...
    • Metformin prevents NGF-dependent proliferative and pro-angiogenic effects in epithelial ovarian cancer and ... 
      Garrido Palma, Maritza; Vega Blanco, María Margarita; Quest, Andrew F. G.; Romero Osses, Carmen (Spandidos Publications Ltd., 2017)
    • mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling 
      Bravo Sagua, Roberto; López Crisosto, Camila; Parra Ortíz, María Valentina; Rodríguez Peña, Marcelo; Rothermel, Beverly A.; Quest, Andrew F. G.; Lavandero González, Sergio (Nature, 2016)
      Efficient mitochondrial Ca2+ uptake takes place at contact points between the ER and mitochondria, and represents a key regulator of many cell functions. In a previous study with HeLa cells, we showed that ER-to-mitochondria ...
    • MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren's syndrome 
      Sung Hsieh, Hsiao; Castro, I.; González, S.; Aguilera, S.; Smorodinsky, N. I.; Quest, Andrew F. G.; Bahamondes Lorca, Verónica; Alliende, Cecilia; Cortés, J.; Molina, Claudio; Urzúa Tobar, Ulises; Barrera, María José; Hermoso Ramello, Marcela; Herrera Cisterna, Luisa; Leyton Martínez, Cecilia; González Burgos, María Julieta (Wiley-Blackwell, 2015)
      OBJECTIVES: To evaluate the expression and localization of MUC1/SEC and MUC1/Y isoforms in labial salivary glands (LSG) from Sj€ogren’s syndrome patients (SS patients), as well as their in vitro expression induced by ...
    • MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjögren's syndrome 
      Sung, H. H.; Castro, I.; González, S.; Aguilera, S.; Smorodinsky, N. I.; Quest, Andrew F. G.; Bahamondes, V.; Alliende, C.; Cortés, J.; Molina, C.; Urzúa, U.; Barrera, M. J.; Hermoso Ramello, Marcela; Herrera, L.; Leyton, C.; González, M. J. (Blackwell, 2015)
      ORIGINAL ARTICLEMUC1/SEC and MUC1/Y overexpression is associatedwith inflammation in Sj€ogren’s syndromeHH Sung1,*, I Castro1,*, S Gonz alez2, S Aguilera3, NI Smorodinsky4, AFG Quest1,5, V Bahamondes1,C Alliende1, J Cort ...
    • Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alpha v ... 
      Ávalos, Ana María; Valdivia, A. D.; Muñoz, Nicolás; Herrera Molina, Rodrigo; Tapia Pineda, Julio; Lavandero González, Sergio; Chiong Lay, Mario; Burridge, Keith; Schneider, P.; Quest, Andrew F. G.; Leyton Campos, Lisette (COMPANY OF BIOLOGISTS LTD, 2009-10)
      Clustering of alpha v beta 3 integrin after interaction with the RGD-like integrin-binding sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation. A ...
    • Oral dryness in Sjögren's syndrome patients. Not just a question of water 
      Castro, I.; Sepúlveda, D.; Cortés, J.; Quest, Andrew F. G.; Barrera, M. J.; Bahamondes, V.; Aguilera, S.; Urzúa Tobar, Ulises; Alliende, C.; Molina, C.; González, S.; Hermoso Ramello, Marcela; Leyton Blanca, Cristina; González, M. J. (Elsevier, 2013)
      Sjögren's syndrome (SS) is a chronic autoimmune disease of undefined etiology. Patients with this syndromesuffer from severe alterations in both the quality and quantity of saliva and tears, due to impaired function of ...
    • Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer 
      Oyarzún Ampuero, Felipe; Guerrero Hernández, Ariel; Hassan López, Natalia; Morales Valenzuela, Javier; Bollo Dragnic, Soledad; Corvalán Rodríguez, Alejandro; Quest, Andrew F. G.; Kogan Bocian, Marcelo (Bentham, 2015)
      Organic and inorganic nanoparticles show great potential for cancer diagnosis and treatment. Because gastric cancer (GC) represents the second most deadly type of neoplasia worldwide, continued research efforts by scientists ...
    • PAR-3 and Syndecan-4 are involved in astrocyte adhesion induced by neuronal Thy-1 
      Cárdenas, A.; Kong, M.; Álvarez, A.; Valdivia, A.; Quest, Andrew F. G.; Leyton, L. (Wiley, 2015)
    • Pro-fibrotic effect of oxidized LDL in cardiac myofibroblasts 
      Villa, Mónica; Cerda Opazo, Paulina; Jiménez Gallegos, Danica; Garrido Moreno, Valeria; Chiong Lay, Mario; Quest, Andrew F. G.; Toledo, Jorge; García Nannig, Lorena (Elsevier, 2020)
      Inflammatory signals associated with cardiac diseases trigger trans-differentiation of cardiac fibroblasts to cardiac myofibroblasts. Cardiac myofibroblasts are the main cell type involved in the development of cardiac ...
    • Regulation of cardiomyocyte autophagy by calcium 
      Shaikh, Soni; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Bravo Sagua, Roberto; García Nannig, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero González, Sergio (Amer Physiological Soc, 2016)
      Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...
    • Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular ... 
      Barrera, María José; Aguilera, Sergio; Veerman, Enno; Quest, Andrew F. G.; Díaz Jiménez, David; Urzúa Tobar, Ulises; Cortés Araya, Juan Eliecer; González, Sergio; Castro, Isabel; Molina, Claudio; Bahamondes, Verónica; Leyton, Cecilia; Hermoso Ramello, Marcela; González Burgos, María Julieta (Oxford Univ Press, 2015)
      Objectives. A hallmark characteristic of SS patients is the ectopic presence of the mucins MUC5B and MUC7 in the extracellular matrix of salivary glands that have lost apical basolateral acinar-cell polarity. This study ...