Browsing by Author "Aguilera, Sergio"

Now showing items 1-17 of 17

    • Aberrant localization of ezrin correlates with salivary acini disorganization in Sjogren's Syndrome. 
      Pérez, Paola; Aguilera, Sergio; Olea, Nancy; Alliende, Cecilia; Molina, Claudio; Brito, Mónica; Barrera, María José; Leyton, Cecilia; Rowzee, Anne; González Burgos, María Julieta (2010)
      To analyse whether the alterations in the structure and organization of microvilli in salivary acinar cells from SS patients are linked to changes in the expression and/or cellular localization of ezrin. Salivary gland ...
    • Aberrant localization of ezrin correlates with salivary acini disorganization in Sjögren’s Syndrome 
      Pérez, Paola; Aguilera, Sergio; Olea, Nancy; Alliende, Cecilia; Molina, Claudio; Brito, Mónica; Barrera, María José; Leyton Martínez, Cecilia; Rowzee, Anne; González Burgos, María Julieta (2010)
      Objectives. To analyse whether the alterations in the structure and organization of microvilli in salivary acinar cells from SS patients are linked to changes in the expression and/or cellular localization of ezrin. Methods. ...
    • Alterations in Type I Hemidesmosome Components Suggestive of Epigenetic Control in the Salivary Glands of ... 
      González, Sergio; Aguilera, Sergio; Alliende, Cecilia; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Herrera Cisterna, Luisa; Molina, Claudio; Hermoso Ramello, Marcela; Ewert, Patricia; Brito, Mónica; Romo, Rafael; Leyton Martínez, Cecilia; Pérez, Paola; González Burgos, María Julieta (2011-04)
      Objective. Acinar cells in the salivary glands of patients with Sjo¨gren’s syndrome (SS) display severe alterations in anchorage to the basal lamina. Bioinformatics analysis of the BP230 gene sequence has revealed the ...
    • Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and ... 
      Lagos, Carolina; Carvajal, Patricia; Castro, Isabel; Jara, Daniela; González, Sergio; Aguilera, Sergio; Barrera, María José; Quest, Andrew F. G.; Bahamondes, Verónica; Molina, Claudio; Urzúa, Ulises; Hermoso Ramello, Marcela; Leyton, Cecilia; González Burgos, María Julieta (Academic Press Inc., 2018)
      © 2018 Elsevier Inc.Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial ...
    • Changes in Rab3D Expression and Distribution in the Acini of Sjogren's Syndrome Patients Are Associated ... 
      Bahamondes, Verónica; Albornoz, Amelina; Aguilera, Sergio; Alliende, Cecilia; Molina, Claudio; Castro, Isabel; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Barrera, María José; González, Sergio; Sánchez, Marianela; Härtel, Steffen; Hermoso Ramello, Marcela; Leyton Martínez, Cecilia; González Burgos, María Julieta (WILEY-BLACKWELL, 2011-10)
      Objective. Oral and ocular dryness are frequent and serious symptoms of Sjogren's syndrome (SS) that reflect problems in secretion due to glandular dysfunction. Exocytosis, an important process in the secretory pathway, ...
    • Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated ... 
      Bahamondes, Verónica; Albornoz, Amelina; Aguilera, Sergio; Alliende, Cecilia; Molina, Claudio; Castro, Isabel; Urzúa, Ulises; Quest, Andrew F. G.; Barrera, María José; González, Sergio; Sánchez, Marianela; Härtel, Steffen; Hermoso Ramello, Marcela; Leyton, Cecilia; González, Ma (2011)
      Objective Oral and ocular dryness are frequent and serious symptoms of Sjögren's syndrome (SS) that reflect problems in secretion due to glandular dysfunction. Exocytosis, an important process in the secretory pathway, ...
    • Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in ... 
      Castro, Isabel; Aguilera, Sergio; Brockhausen, Inka; Alliende, Cecilia; Quest, Andrew F. G.; Molina, Claudio; Urzúa Tobar, Ulises; Mandel, Ulla; Bahamondes, Verónica; Barrera, María José; Sánchez, Marianela; González, Sergio; Hermoso Ramello, Marcela; Leyton Martínez, Cecilia; González Burgos, María Julieta (Oxford University Press, 2012)
      Objectives. To determine the expression and enzymatic activities of sulphotransferases involved in mucin hyposulphation in labial salivary glands (LSGs) from SS patients and to correlate sulphotransferase activity with ...
    • Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to ... 
      Ewert, Patricia; Aguilera, Sergio; Alliende, Cecilia; Kwon, Yoon Jeoung; Albornoz, Amelina; Molina, Claudio; Urzúa, Ulises; Quest, Andrew F. G.; Olea, Nancy; Pérez, Paola; Castro, Isabel; Barrera, María José; Romo, Rafael; Hermoso Ramello, Marcela; Leyton, Cecilia; González, Mar (2010)
      Objective. Disorganization of acinar cell apical microvilli and the presence of stromal collagen in the acinar lumen suggest that the labial salivary gland (LSG) barrier function is impaired in patients with Sjögren's ...
    • Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded ... 
      Barrera, María José; Aguilera, Sergio; Castro, Isabel; González, Sergio; Carvajal, Patricia; Molina, Claudio; Hermoso, Marcela A.; González, María Julieta (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. For many years, researchers in the field of autoimmunity have focused on the role of the immune components in the etiopathogenesis of autoimmune diseases. However, some studies have demonstrated the ...
    • Gene expression and chromosomal location for susceptibility to Sjögren's syndrome 
      Pérez, Paola; Anaya, Juan Manuel; Aguilera, Sergio; Urzúa Tobar, Ulises; Munroe, David; Molina, Claudio; Hermoso Ramello, Marcela; Cherry, James Michael; Alliende, Cecilia; Olea, Nancy; Ruiz-Narváez, Edward; González Burgos, María Julieta (2009)
      Primary Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease affecting mainly the exocrine glands. Its physio-pathology is poorly understood and most of the knowledge has been related to the inflammatory ...
    • Increased acinar damage of salivary glands of patients with Sjogren's syndrome is paralleled by simultaneous ... 
      Pérez, Paola; Kwon, Yoon-Jeoung; Alliende, Cecilia; Leyton Campos, Lisette; Aguilera, Sergio; Molina, Claudio; Labra, Cecilia; Julio, Marcelo; Leyton Martínez, Cecilia; González Burgos, María Julieta (WILEY-LISS, DIV JOHN WILEY & SONS INC, 2005-09)
      Objective. Previous findings in labial salivary glands (LSGs) from patients with Sjogren ' s syndrome (SS) suggest that increased activity and expression of matrix metalloproteinase 9 (MMP-9) and MMP-3 trigger the destruction ...
    • Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary ... 
      Kwon, Yoon Jeoung; Pérez, Paola; Aguilera, Sergio; Molina, Claudio; Leyton Campos, Lisette; Alliende, Cecilia; Leyton, Cecilia; Brito, Mónica; Romo, Rafael; González Burgos, María Julieta (2006)
      Objective. To investigate remodeling of the basal lamina of labial salivary glands (LSGs) from patients with Sjögren's syndrome (SS) by analyzing the expression of specific components that participate in its assembly and ...
    • Mechanotransduction and epigenetic control in autoimmune diseases 
      González, Sergio; Aguilera, Sergio; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Molina, Claudio; Alliende, Cecilia; Hermoso Ramello, Marcela; González Burgos, María Julieta (Elsevier, 2011)
      Differentiation of epithelial cells is required to define tissue architecture and appropriate function of these cells is associated with a specific pattern of gene expression. DNA methylation, post-translational modification ...
    • Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren's ... 
      Barrera, María José; Aguilera, Sergio; Castro, Isabel; Cortés Araya, Juan Eliecer; Bahamondes Lorca, Verónica; Quest, Andrew F. G.; Molina, Claudio; González, Sergio; Hermoso Ramello, Marcela; Urzúa Tobar, Ulises; Leyton, Cecilia; González Burgos, María Julieta (Elsevier, 2016)
      Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of synthesized secretory products. SGs of Sji5gren's syndrome patients (SS)-patients ...
    • Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular ... 
      Barrera, María José; Aguilera, Sergio; Veerman, Enno; Quest, Andrew F. G.; Díaz Jiménez, David; Urzúa Tobar, Ulises; Cortés Araya, Juan Eliecer; González, Sergio; Castro, Isabel; Molina, Claudio; Bahamondes, Verónica; Leyton, Cecilia; Hermoso Ramello, Marcela; González Burgos, María Julieta (Oxford Univ Press, 2015)
      Objectives. A hallmark characteristic of SS patients is the ectopic presence of the mucins MUC5B and MUC7 in the extracellular matrix of salivary glands that have lost apical basolateral acinar-cell polarity. This study ...
    • Small RNA expression profiling reveals hsa-miR-181d-5p downregulation associated with TNF-α overexpression ... 
      Castro Masso, Isabel Verónica; Carvajal Garcés, Patricia Alejandra; Jara, Daniela; Aguilera, Sergio; Heathcote Pérez, Benjamín Norman; Barrera, María José; Aliaga Tobar, Víctor Manuel; Maracaja Coutinho, Vinicius; Urzúa Tobar, Ulises; Quest, Andrew Frederick Geoffery; González, Sergio; Claudio, Molina; Hermoso, Marcela Alejandra; González Burgos, María Julieta (Frontiers Media, 2022)
      MicroRNAs (miRNAs) are small non-coding RNAs (sRNA), that alter gene expression by binding to target messenger RNAs (mRNAs) and repressing translation. Dysregulated miRNA expression has been implicated in the pathogenesis ...
    • Type I interferon dependent hsa-miR-145-5p downregulation modulates MUC1 and TLR4 overexpression in salivary ... 
      Jara, Daniela; Carvajal, Patricia; Castro Masso, Isabel Verónica; Barrera, María José; Aguilera, Sergio; González, Sergio; Molina, Claudio; Hermoso, Marcela Alejandra; González Burgos, María Antonieta (Frontiers Media, 2021)
      Sjögren’s syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and is characterized by overactivation of the type I interferon (IFN) pathway. Type I IFNs can decrease the levels of hsa-miR-145-5p, ...