Browsing by Author "Aguilera Venegas, Benjamín"

Now showing items 1-10 of 10

    • Biological and chemical study of fused tri- and tetracyclic indazoles and analogues with important antiparasitic ... 
      Díaz Urrutia, Christian; Olea Azar, Claudio; Zapata, Gerald A.; Lapier, Michel; Mura Mardones, Francisco; Aguilera Venegas, Benjamín; Arán, Vicente J.; López Muñoz, Rodrigo; Maya Arango, Juan (2012)
      A series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic ...
    • Electrochemical and spectroscopic investigation of bioactive naphthoquinones 
      Costa, Erivaldo de Oliveira; Molina, María Teresa; De Abreu, Fabiane C.; dos Santos Silva, Francisco de Assis; Costa, Cicero de Oliveira; Pinho, Waldomiro; Valentim, Iara B.; Aguilera Venegas, Benjamín; Pérez Cruz, Fernanda; Norambuena, Ester; Olea Azar, Claudio (2012)
      The present work aims to investigate the electrochemical behavior of nine naphthoquinones, in aprotic and protic media. The reduction mechanism of the quinones in aprotic medium was proposed, with involvement of anion ...
    • Electrochemical, ESR and theoretical insights into the free radical generation by 1,1'-hydrocarbylenebisindazoles ... 
      Aguilera Venegas, Benjamín; Olea Azar, Claudio; Arán, Vicente J.; Maya Arango, Juan; Kemmerling Weis, Ulrike; Speisky Cosoy, Hernán; Mendizábal Emaldía, Fernando (2012)
      A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
    • Evaluating 5-Nitrothiazoles as Trypanocidal Agents 
      O'Shea, Iván P.; Shahed, Mohammed; Aguilera Venegas, Benjamín; Wilkinson, Shane R. (Amer Soc Microbiology, 2016)
      The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic ...
    • Evaluation of the novel antichagasic activity of [1,2,3]triazolo[1,5-a]pyridine derivatives 
      Lapier, Michel; Zúñiga López, María C.; Aguilera Venegas, Benjamín; Adam, Rosa; Abarca, Belén; Ballesteros, Rafael; López Muñoz, Rodrigo; Maya Arango, Juan; Olea Azar, Claudio (Bentham Science Publishers B.V., 2017)
      © 2017 Bentham Science Publishers. Trypanosoma cruzi is the causative agent of Chagas disease. This parasite is vulnerable to the effects of ROS as its main defense mechanism against exogenous agents trypanothione is also ...
    • Host-guest interaction between new nitrooxoisoaporphine and β-cyclodextrins: Synthesis, electrochemical, ... 
      Pérez Cruz, Fernanda; Aguilera Venegas, Benjamín; Lapier, Michel; Sobarzo Sánchez, Eduardo; Uriarte Villares, Eugenio; Olea Azar, Claudio (2013)
      A new nitrooxoisoaporphine derivative was synthetized and characterized by cyclic voltammetry and electron spin resonance. Its aqueous solubility was improved by complexes formation with β-cyclodextrin, heptakis(2,6-di-O- ...
    • Host–guest interaction between new nitrooxoisoaporphine and b-cyclodextrins: Synthesis, electrochemical, ... 
      Pérez Cruz, Fernanda; Aguilera Venegas, Benjamín; Lapier, Michel; Sobarzo Sánchez, Eduardo; Uriarte Villares, Eugenio; Olea Azar, Claudio (Elsevier, 2012-10-26)
      A new nitrooxoisoaporphine derivative was synthetized and characterized by cyclic voltammetry and electron spin resonance. Its aqueous solubility was improved by complexes formation with b-cyclodextrin, heptakis(2,6-di ...
    • Identification of the transition state for fast reactions: The trapping of hydroxyl and methyl radicals by ... 
      Aguilera Venegas, Benjamín; Speisky Cosoy, Hernán (Elsevier Inc., 2014)
      Up to date, attempts to locate the transition state (TS) for the trapping reaction between ̇OH and ̇DMPO have been unsuccessful, and the lack of molecular mechanisms by which ̇OH binds to the spin-trap constitutes a question ...
    • Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruzi 
      Maya Arango, Juan; Salas, C. O.; Aguilera Venegas, Benjamín; Diaz, M. V.; López-Muñoz, R. (Bentham Science Publishers B.V., 2014)
      In trypanosomatids, redox homeostasis is centered on trypanothione (N 1,N8-bis(glutathionyl)spermidine, T(SH)2), a low molecular weight thiol that is distinctive for this taxonomic family and not present in the mammalian ...
    • Spin Trapping: An Essential Tool for the Study of Diseases Caused by Oxidative Stress 
      Barriga González, Germán; Olea Azar, Claudio; Zúñiga López, María C.; Folch Cano, Christian; Aguilera Venegas, Benjamín; Porcal, Williams; González, Mercedes; Cerecetto, Hugo (Bentham Science Publ, 2015)
      Electron spin resonance (ESR), called also electron paramagnetic resonance (EPR) together with the spin trapping technique, has allowed us to study and understand how free radicals are involved in various pathologies. In ...