Browsing by Author "Alfaro, Iván E."

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    • Chaperone mediated autophagy in the crosstalk of neurodegenerative diseases and metabolic disorders 
      Alfaro, Iván E.; Albornoz, Amelina; Molina, Alfredo; Moreno, José; Cordero, Karina; Criollo Céspedes, Alfredo; Budini, Mauricio (Frontiers Media, 2019)
      Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major protein players of CMA are LAMP-2A and HSC70. While ...
    • Palmitic and stearic acids inhibit chaperone-mediated autophagy (CMA) in POMC-like neurons In vitro 
      Espinosa Lemunao, Rodrigo; Gutiérrez, Karla; Ríos Castillo, Javiera; Ormeño, Fernando; Yantén, Liliana; Galaz Davison, Pablo; Ramírez Sarmiento, César; Parra Ortiz, Valentina; Albornoz, Amelina; Alfaro, Iván E.; Burgos, Patricia; Morselli, Eugenia; Criollo Céspedes, Alfredo; Budini, Mauricio (MDPI, 2022)
      The intake of food with high levels of saturated fatty acids (SatFAs) is associated with the development of obesity and insulin resistance. SatFAs, such as palmitic (PA) and stearic (SA) acids, have been shown to accumulate ...