Browsing by Author "Araya, Magdalena"

Now showing items 1-20 of 28

    • Administration of High Doses of Copper to Capuchin Monkeys Does Not Cause Liver Damage but Induces ... 
      Araya, Magdalena; Núñez, Héctor; Pavez, Leonardo; Arredondo Olguín, Miguel Armando; Méndez, Marco; Cisternas, Felipe; Pizarro Aguirre, Fernando; Sierralta, Walter; Uauy Dagach-Imbarack, Ricardo; González Canales, Mauricio (American Society for Nutrition, 2012)
      Liver cells respond to copper loading upregulating protective mechanisms. However, to date, except for liver content, there are no good indicators that identify individuals with excess liver copper. We hypothesized that ...
    • Assessing chaperone for Zn, Cu-superoxide dismutase as an indicator of copper deficiency in malnourished children 
      Arredondo Olguín, Miguel; Weisstaub Nuta, Sergio; Medina, Marcos; Suazo Romo, Miriam; Guzmán, Miguel; Araya, Magdalena (Elsevier, 2014)
      It is not clear how frequent is copper deficiency in humans. Current copper markers are not sensitive enough to detect early copper deficiency and new markers are needed. CCS is a candidate to become a copper ...
    • Avoiding small intestinal biopsies for diagnosis of celiac disease in children: a reliable strategy for all ... 
      Araya, Magdalena; Diaz, Julia; Oyarzún, Amaya; Lucero, Yalda; Alarcón, Teresa; Gonzalez, Monica; Canales, Paulina; Fierro, Liliana; Pérez Bravo, Francisco (Lippincott Williams & Wilkings, 2018)
      Background: Current reports applying ESPGHAN exception criteria (EEC) to diagnose celiac disease (CD) without duodenal biopsies indicate that a high percentage of patients with CD may be identified when applied correctly ...
    • Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos 
      Bejares Cárdenas, Marcela; Oyarzún, Amaya; Lucero Álvarez, Yalda; Espinoza, Nelly; Bascuñán Gamboa, Karla; Araya, Magdalena (Sociedad Médica de Santiago, 2015)
      Active search of celiac disease (CD) among risk groups has significantly increased the scope of known clinical variants. Aim: To measure the frequency and clinical characteristics of CD among first degree relatives (FDR) ...
    • Cambios del patrón de enfermedad en la postransición epidemiológica en salud en Chile, 1950-2003 
      Luque, Cecilia; Cisternas, Felipe A.; Araya, Magdalena (2006)
      Background: During the twentieth century there was a change in the pattern of diseases in Europe, with an increase in the incidence of allergies and autoimmune disorders, that paralleled a decrease of infectious conditions. ...
    • Caso de empresa Industria salmonera chilena: esplendor y crisis 
      Oliva Becerra, Ismael; Concha, Guillermo; Araya, Magdalena (Universidad de Chile. Facultad de Economía y Negocios., 2009)
      En 1981 encontramos que Chile ya se había convertido en el segundo productor de salmones en el mundo, con 245.000 toneladas anuales, siendo superado solamente por Noruega con 420.000 toneladas anuales de producción. Para ...
    • CCS mRNA transcripts and serum CCS protein as copper marker in adults suffering inflammatory processes 
      Araya, Magdalena; Gutiérrez, Ricardo; Arredondo Olguín, Miguel (Springer, 2014)
      The chaperone to Zn–Cu superoxide dismutase (CCS) has been postulated as a candidate copper indicator, changing in a consistent manner in induced and recovered copper deficiency, in experimental cell and animal models. ...
    • Chaperones CCS, ATOX and COXIV responses to copper supplementation in healthy adults 
      Araya, Magdalena; Andrews, Mónica; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel Armando (Springer, 2012-04)
      Assessment of proteins in blood and other tissues has failed to identify markers of early copper effects on health. Studies in animal models show that chaperone of SOD (CCS) respond to changes of copper status. Evidence ...
    • Community-based randomized double-blind study of gastrointestinal effects and copper exposure in drinking water 
      Araya, Magdalena; Olivares Grohnert, Manuel; Pizarro Aguirre, Fernando; Llanos, Adolfo; Figueroa, Guillermo; Uauy Dagach-Imbarack, Ricardo (US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, 2004-07)
      We assessed gastrointestinal effects in 1,365 adults exposed to either < 0.01 (controls), 2, 4, or 6 mg copper/L of drinking water for 2 months in a randomized, double-blind community-based study. The risk of symptoms ...
    • Confirmation of an acute no-ob served-adverse-effect and low-observed-adverse-effect level for copper in ... 
      Araya, Magdalena; Chen, Bingheng; Klevay, Leslie M.; Strain, J. J.; Johnson, Luann; Robson, Paula; Shi, Wei; Nielsen, Forrest; Zhu, Huigang; Olivares Grohnert, Manuel; Pizarro Aguirre, Fernando; Haber, Lynne T. (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2003-12)
      In a double blind, 3 x 3 factorial (volume x dose) study, 70 adult females (18-60 years of age) at four different international sites (total pooled n = 269) were given 100, 150, or 200 ml of bottled drinking water with ...
    • Copper Supplementation at 8 mg Neither Affects Circulating Lipids nor Liver Function in Apparently Healthy ... 
      Rojas Sobarzo, Loreto; Olivares Grohnert, Manuel; Brito, Alex; Suazo Romo, Miriam; Araya, Magdalena; Pizarro Aguirre, Fernando (Springer, 2013)
      Copper (Cu) deficiency has been reported to influence lipid metabolism, but the effects in humans are controversial. To evaluate the effects of 8 mg Cu/day supplementation (as copper sulfate) for 6 months on the lipid ...
    • Differential response of interleukin-2 production to chronic copper supplementation in healthy humans 
      Muñoz, Carlos; López, Marcelo; Olivares Grohnert, Manuel; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel Armando; Araya, Magdalena (EUROPEAN CYTOKINE NETWORK, 2005-12)
      Backgound. Copper (Cu) is an essential trace element for many biological processes including maintenance of both innate and acquired branches of immunity. Objective. To measure the effect of copper supplementation on IL-2 ...
    • DQ2, DQ7 and DQ8 Distribution and Clinical Manifestations in Celiac Cases and Their First-Degree Relatives 
      Araya, Magdalena; Oyarzún, Amaya; Lucero Álvarez, Yalda; Espinosa, Nelly; Pérez Bravo, Francisco (MDPI AG, 2015)
      HLA-linked genes are relevant to celiac disease (CD); the potential genetic differences present worldwide are not fully understood. Previous results suggest that the distribution of HLA-DQ2/DQ7/DQ8 in Chile may differ from ...
    • Effects of chronic copper exposure during early life in rhesus monkeys 
      Araya, Magdalena; Kelleher, Shannon; Arredondo Olguín, Miguel; Sierralta, Walter; Vial, María Teresa; Uauy Dagach-Imbarack, Ricardo; Lonnerdal, Bo (AMER SOC CLINICAL NUTRITION, 2005-05)
      Background: Whether infants regulate copper absorption and the potential effects of excess copper in early life remain poorly defined. Objective: The objective of the study was to assess copper retention, liver copper ...
    • Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca. Estudio multicéntrico 
      Canales, Paulina; Araya, Magdalena; Alliende G., Francisco; Hunter, Bessie; Alarcón Orellana, Teresa; Chávez S., Eduardo (SOC MEDICA SANTIAGO, 2008-03)
      Background: Ample use of serological markets of high sensitivity and specificity led to relevant changes in the epidemiology of celiac disease. The impact of these changes in our country is poorly known. Aim: To assess the ...
    • Estrés oxidativo, prooxidantes y enfermedad de Crohn 
      Tapia S., Alexis; Araya, Magdalena (2006)
      The frequency of Crohn disease shows a significant increase in the last century. Affected patients show a misbalance between production of free radicals and anti oxidant defenses. Thus, one of the increasingly accepted ...
    • El gluten. Su historia y efectos en la enfermedad celíaca 
      Parada, Alejandra; Araya, Magdalena (SOC MEDICA SANTIAGO, 2010-10)
      The global prevalence of celiac disease is of one person per 250 inhabitants. The disease is induced by gluten, a peptide contained in wheat, rye and barley that during small intestinal digestion generates smaller peptides. ...
    • Helicobacter pylori cagA + is associated with milder duodenal histological changes in chilean celiac patients 
      Lucero Álvarez, Yalda; Oyarzún, Amaya; O'Ryan Gallardo, Miguel; Valenzuela, Romina; Alcalde Ruíz, Elisa; Arce Fricke, Claudio; Farfán Urzúa, Mauricio; Vergara, Alejandra F.; Sandoval Gajardo, Iván Elías; Méndez, Jocelyn; Carrasco, Jorge; Ossa Alemparte, Juan; Pérez Bravo, Francisco; Castro Lebrero, Magdalena; Araya, Magdalena (Frontiers Media, 2017)
      Background: Mechanisms underlying the high clinical and histological diversity of celiac disease (CD) remain elusive. Helicobacter pylori (Hp) chronically infects gastric and duodenal mucosa and has been associated with ...
    • How reliable and robust are current biomarkers for copper status? - Reply by Danzeisen 
      Danzeisen, Ruth; Araya, Magdalena; Harrison, Brenda; Keen, Carl; Solioz, Marc; Thiele, Dennis; Mcardle, Harry J. (2008)
    • Mejorar el manejo de la enfermedad celíaca. Un desafío urgente 
      Araya, Magdalena (2006)
      Anti endomysial and anti transglutaminase (EMA/TTG) antibodies measurements in large population groups, show that celiac disease is significantly more common than previously thought and 0.5-1% of the population suffer ...