Browsing by Author "Armisen Yáñez, Ricardo"

Now showing items 1-14 of 14

    • ALS-linked protein disulfide isomerase variants cause motor dysfunction 
      Woehlbier, Ute; Colombo Flores, Alicia; Saaranen, Mirva J.; Pérez, Viviana; Ojeda, Jorge; Bustos, Fernando J.; Andreu, Catherine; Torres, Mauricio; Valenzuela, Vicente; Medinas Bilches, Danilo; Rozas, Pablo; Vidal, René L.; López González, Rodrigo; Salameh, Johnny; Fernández Collemann, Sara; Muñoz, Natalia; Matus, Soledad; Armisen Yáñez, Ricardo; Sagredo, Alfredo; Palma, Karina; Irrázabal, Thergiory; Almeida, Sandra; González Pérez, Paloma; Campero, Mario; Gao, Fen-Biao; Henny, Pablo; Van Zundert, Brigitte; Ruddock, Lloyd W.; Concha, Miguel L.; Henríquez, Juan P.; Brown, Robert H.; Hetz Flores, Claudio (Wiley-Blackwell, 2016)
      Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic lateral sclerosis (ALS). Protein disulfide isomerases (PDIs) are ER foldases identified as possible ALS biomarkers, as well as ...
    • BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded ... 
      Rodriguez, Diego A.; Zamorano, Sebastian; Lisbona, Fernanda; Rojas Rivera, Diego; Urra, Hery; Cubillos-Ruiz, Juan R.; Armisen Yáñez, Ricardo; Henriquez, Daniel R.; Cheng, Emily; Letek, Michal; Vaisar, Tomas; Irrazabal, Thergiory; González Billault, Christian; Letai, Antho (2012)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α(IRE1α), which functions as an endoribonuclease that splices the ...
    • Chromosomal Instability in Mouse Embryonic Fibroblasts Null for the Transcriptional Co-Repressor Ski 
      Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Aguirre, Adam; Ueki, Nobuhide; Toro, Jessica; Colmenares, Clemencia; Hayman, Michael J. (WILEY-BLACKWELL, 2012-01)
      Ski is a transcriptional regulator that has been considered an oncoprotein given its ability to induce oncogenic transformation in avian model systems. However, studies in mouse and in some human tumor cells have also ...
    • CK2 functionally interacts with AKT/PKB to promote the β-catenin- dependent expression of survivin and ... 
      Ponce, Daniela P.; Yefi, Roger; Cabello, Pablo; Maturana, Jose L.; Niechi, Ignacio; Silva, Eduardo; Galindo, Mario; Antonelli, Marcelo; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Tapia, Julio C. (2011)
      β-Catenin is crucial in the canonical Wnt signaling pathway. This pathway is up-regulated by CK2 which is associated with an enhanced expression of the antiapoptotic protein survivin, although the underlying molecular ...
    • Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting ... 
      Niechi, Ignacio; Silva, Eduardo; Cabello, Pablo; Huerta, Hernán; Carrasco, Valentina; Villar, Paulina; Cataldo, Luis; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Varas Godoy, Manuel; Fernández, Cristina; Tapia, Julio (Impact Journals LLC, 2015)
      Endothelin-converting enzyme-1c (ECE-1c) is a membrane metalloprotease involved in endothelin-1 synthesis, which has been shown in vitro to have a role in breast, ovary and prostate cancer cell invasion. N-terminal end of ...
    • Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor ... 
      Echeverría, César; Montorfano, Ignacio; Hermosilla, Tamara; Armisen Yáñez, Ricardo; Velásquez, Luis A.; Caballero Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (PLOS One, 2014)
      The pathogenesis of systemic inflammatory diseases, including endotoxemia-derived sepsis syndrome, is characterized by endothelial dysfunction. It has been demonstrated that the endotoxin lipopolysaccharide (LPS) induces ...
    • Human peritoneal mesothelial cell death induced by high-glucose hypertonic solutioninvolves Ca2+ and Na+ ... 
      Simon, Felipe; Tapia, Pablo; Armisen Yáñez, Ricardo; Echeverría, César; Gatica, Sebastián; Vallejos, Alejandro; Pacheco Durán, Alejandro; Sanhueza Villanueva, María Eugenia; Alvo Abodovsky, Miriam; Segovia, Erico; Torres, Rubén (Frontiers Media, 2017)
      Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, ...
    • Identification of Ski as a target for Aurora A kinase 
      Mosquera, Jocelyn; Armisen Yáñez, Ricardo; Zhao, Hongling; Rojas, Diego A.; Maldonado, Edio; Tapia, Julio C.; Colombo, Alicia; Hayman, Michael J.; Marcelain Cubillos, Katherine (2011)
      Ski is a negative regulator of the transforming growth factor-β and other signalling pathways. The absence of SKI in mouse fibroblasts leads to chromosome segregation defects and genomic instability, suggesting a role for ...
    • Modal gating in neuronal and skeletal muscle ryanodine-sensitive Ca2+ release channels 
      Armisen Yáñez, Ricardo; Sierralta, J.; Vélez, P.; Naranjo, D.; Suárez Isla, Benjamín (1996)
      The bursting behavior of ryanodine-sensitive single Ca2+ release channels present in chicken cerebellum endoplasmic reticulum (ER), rat hippocampus ER, and frog and rabbit skeletal muscle sarcoplasmic reticulum was ...
    • Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional ... 
      Ponce, Daniela P.; Maturana, Jose L.; Cabello, Pablo; Yefi, Roger; Niechi, Ignacio; Silva, Eduardo; Armisen Yáñez, Ricardo; Galindo, Mario; Antonelli, Marcelo; Tapia, Julio C. (2011)
      β-Catenin is a key protein in the canonical Wnt signaling pathway and in many cancers alterations in transcriptional activity of its components are observed. This pathway is up-regulated by the protein kinase CK2, but the ...
    • Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and ... 
      Yefi, Roger; Ponce, Daniela P.; Niechi, Ignacio; Silva, Eduardo; Cabello, Pablo; Rodriguez, Diego A.; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Quest, Andrew F. G.; Tapia, Julio C. (2011)
      Augmented expression of protein kinase CK2 is associated with hyperproliferation and resistance to apoptosis in cancer cells. Effects of CK2 are at least partially linked to signaling via the Wnt/β-catenin pathway, which ...
    • Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium ... 
      Armisen Yáñez, Ricardo; Fuentes, Rómulo; Olguín, Patricio; Cabrejos, María E.; Kukuljan Padilla, Manuel (2002)
      The ability of neurons to fire rapid action potential relies on the expression of voltage-gated sodium channels; the onset of the transcription of genes that encode these channels occurs during early neuronal development. ...
    • The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A 
      Rivas, Solange; Armisen Yáñez, Ricardo; Rojas, Diego A.; Maldonado Maldonado, Edio; Huerta, Hernán; Tapia, Julio C.; Espinoza, Jaime; Colombo, Alicia; Michea Acevedo, Luis; Hayman, Michael J.; Marcelain Cubillos, Katherine (Wiley & Sons, 2016)
      Oncogenic kinase Aurora A (AURKA) has been found to be overexpresed in several tumors including colorectal, breast, and hematological cancers. Overexpression of AURKA induces centrosome amplification and aneuploidy and it ...
    • TRPM4 regulates Akt/GSK3-b activity and enhances b-catenin signaling and cell proliferation in prostate ... 
      Sagredo, A.; Sagredo, Eduardo A.; Cappelli, Claudio; Baez, Pablo; Andaur, Rodrigo E.; Blanco, Constanza; Tapia, Julio C.; Echeverría, César; Cerda, Oscar; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (John Wiley, 2018)
      Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism underlying its effect remains unknown. This work found that decreasing ...