Browsing by Author "Barrera, María José"

Now showing items 1-7 of 7

    • Aberrant localization of ezrin correlates with salivary acini disorganization in Sjögren’s Syndrome 
      Pérez, Paola; Aguilera, Sergio; Olea, Nancy; Alliende, Cecilia; Molina, Claudio; Brito, Mónica; Barrera, María José; Leyton Martínez, Cecilia; Rowzee, Anne; González Burgos, María Julieta (2010)
      Objectives. To analyse whether the alterations in the structure and organization of microvilli in salivary acinar cells from SS patients are linked to changes in the expression and/or cellular localization of ezrin. Methods. ...
    • Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in ... 
      Castro, Isabel; Aguilera, Sergio; Brockhausen, Inka; Alliende, Cecilia; Quest, Andrew F. G.; Molina, Claudio; Urzúa Tobar, Ulises; Mandel, Ulla; Bahamondes, Verónica; Barrera, María José; Sánchez, Marianela; González, Sergio; Hermoso Ramello, Marcela; Leyton Martínez, Cecilia; González Burgos, María Julieta (Oxford University Press, 2012)
      Objectives. To determine the expression and enzymatic activities of sulphotransferases involved in mucin hyposulphation in labial salivary glands (LSGs) from SS patients and to correlate sulphotransferase activity with ...
    • Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren's ... 
      Barrera, María José; Aguilera, Sergio; Castro, Isabel; Cortés Araya, Juan Eliecer; Bahamondes Lorca, Verónica; Quest, Andrew F. G.; Molina, Claudio; González, Sergio; Hermoso Ramello, Marcela; Urzúa Tobar, Ulises; Leyton, Cecilia; González Burgos, María Julieta (Elsevier, 2016)
      Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of synthesized secretory products. SGs of Sji5gren's syndrome patients (SS)-patients ...
    • Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular ... 
      Barrera, María José; Aguilera, Sergio; Veerman, Enno; Quest, Andrew F. G.; Díaz Jiménez, David; Urzúa Tobar, Ulises; Cortés Araya, Juan Eliecer; González, Sergio; Castro, Isabel; Molina, Claudio; Bahamondes, Verónica; Leyton, Cecilia; Hermoso Ramello, Marcela; González Burgos, María Julieta (Oxford Univ Press, 2015)
      Objectives. A hallmark characteristic of SS patients is the ectopic presence of the mucins MUC5B and MUC7 in the extracellular matrix of salivary glands that have lost apical basolateral acinar-cell polarity. This study ...
    • Small RNA expression profiling reveals hsa-miR-181d-5p downregulation associated with TNF-α overexpression ... 
      Castro Masso, Isabel Verónica; Carvajal Garcés, Patricia Alejandra; Jara, Daniela; Aguilera, Sergio; Heathcote Pérez, Benjamín Norman; Barrera, María José; Aliaga Tobar, Víctor Manuel; Maracaja Coutinho, Vinicius; Urzúa Tobar, Ulises; Quest, Andrew Frederick Geoffery; González, Sergio; Claudio, Molina; Hermoso, Marcela Alejandra; González Burgos, María Julieta (Frontiers Media, 2022)
      MicroRNAs (miRNAs) are small non-coding RNAs (sRNA), that alter gene expression by binding to target messenger RNAs (mRNAs) and repressing translation. Dysregulated miRNA expression has been implicated in the pathogenesis ...
    • Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its ... 
      Cavieres, Viviana A.; González, Alexis; Muñoz, Vanessa C.; Yefi, Claudia P.; Bustamante, Hianara A.; Barraza, Rafael R.; Tapia Rojas, Cheril; Otth, Carola; Barrera, María José; González, Carlos; Mardones, Gonzalo A.; Inestrosa, Nibaldo C.; Burgos, Patricia V. (Public Library Science, 2015)
      Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-beta (A beta) peptide. We have previously shown that the compound tetrahydrohyperforin (IDN5706) prevents accumulation ...
    • Type I interferon dependent hsa-miR-145-5p downregulation modulates MUC1 and TLR4 overexpression in salivary ... 
      Jara, Daniela; Carvajal, Patricia; Castro Masso, Isabel Verónica; Barrera, María José; Aguilera, Sergio; González, Sergio; Molina, Claudio; Hermoso, Marcela Alejandra; González Burgos, María Antonieta (Frontiers Media, 2021)
      Sjögren’s syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and is characterized by overactivation of the type I interferon (IFN) pathway. Type I IFNs can decrease the levels of hsa-miR-145-5p, ...