Browsing by Author "Benites, Julio"

Now showing items 1-6 of 6

    • Antifungal activity and In silico studies on 2-acylated benzo- and naphthohydroquinones 
      Ríos, David; Valderrama, Jaime A.; Quiroga, Gonzalo; Michea, Jonathan; Salas, Felipe; Álvarez Duarte, Eduardo Andrés; Venegas Casanova, Edmundo A.; Jara Aguilar, Rafael; Navarro Retamal, Carlos; Buc Caldero, Pedro; Benites, Julio (MDPI, 2022)
      The high rates of morbidity and mortality due to fungal infections are associated with a limited antifungal arsenal and the high toxicity of drugs. Therefore, the identification of novel drug targets is challenging due to ...
    • Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly 
      Gutiérrez, Eunices; Benites, Julio; Valderrama, Jaime; Buc Calderón, Pedro; Verrax, Julien; Nova Martínez, Esteban; Villanelo Lizana, Felipe; Maturana Middleton, Daniel; Escobar, Cristian; Lagos Mónaco, Rosalba; Monasterio Opazo, Octavio (Elsevier, 2015)
      Dihydroxynaphthyl aryl ketones 1e5 have been evaluated for their abilities to inhibit microtubule assembly and the binding to tubulin. Compounds 3, 4 and 5 displayed competitive inhibition against colchicine binding, and ...
    • Gastroprotective activity of ent-beyerene derivatives in mice: Effects on gastric secretion, endogenous ... 
      Parra, Teresa; Benites, Julio; Ruiz, Lina M.; Sepúlveda, Beatriz; Simirgiotis, Mario; Areche Medina, Carlos (Elsevier, 2015)
      Seventeen compounds (2-18) synthetized from the diterpenoid ent-beyer-15-en-18-ol (1) isolated from aerial part of Baccharis tola were tested for their gastroprotective activity on the model of HCl/EtOH-induced gastric ...
    • Seco-Taondiol, an Unusual Meroterpenoid from the Chilean Seaweed Stypopodium flabelliforme and Its ... 
      Areche Medina, Carlos; Benites, Julio; Cornejo, Alberto; Ruiz, Lina M.; García Beltrán, Olimpo; Simirgiotis, Mario J.; Sepúlveda, Beatriz (2015)
      Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the ...
    • Studies on quinones. Part 38: Synthesis and leishmanicidal activity of sesquiterpene 1,4-quinones 
      Valderrama, Jaime A.; Benites, Julio; Cortés, Manuel; Pessoa Mahana, Hernán; Prina, Eric; Fournet, Alain (PERGAMON-ELSEVIER SCIENCE LTD, 2003-11-03)
      The reaction of (+)-euryfuran 1 with several benzo-, naphtho- and benzo[b]thiophene-1,4-quinones in acetic acid yields the corresponding euryfuryl-1.4-quinones 3, 5, 7, 8, 10, 12, and 14. The structure of compounds 7, 8, ...
    • Time course of endocrine changes in the hypophysis-gonad axis induced by hypobaric hypoxia in male rats 
      Farías, Jorge Gonzalo; Bustos Obregón, Eduardo; Tapia, Pablo José; Gutiérrez, Eduardo; Zepeda, Andrea; Juantok, Camila; Cruz, Gonzalo; Soto, Gustavo; Benites, Julio; Reyes, Juan Guillermo (JAPANESE SOC ANIMAL REPRODUCTION, 2008-02)
      Chronic hypobaric hypoxia. (CHH) induces a decrease in sperm output and spermatogenesis in male rats. The mechanisms that underlie these changes in testicular function are unknown and could involve changes in the ...