Browsing by Author "Cárdenas, Ana María"

Now showing items 1-8 of 8

    • Broadening the imaging phenotype of dysferlinopathy at different diseasestages 
      Díaz Jara, Jorge; Woudt, Lisanne; Suazo Rojas, Lionel Andrés; Garrido Inostroza, Cristian Alejandro; Caviedes Fernández, Pablo; Cárdenas, Ana María; Bevilacqua, Jorge (2016)
      Introduction: MRI characterization of dysferlinopathy has been mostly limited to the lower limbs. We aimed to broaden the MRI description of dysferlinopathy and to correlate it with objective measures of motor dysfunction. ...
    • Cell lines as in vitro models for drug screening and toxicity studies 
      Allen, David D.; Caviedes Codelia, Raúl; Cárdenas, Ana María; Shimahara, Takeshi; Segura Aguilar, Juan; Caviedes Fernández, Pablo (DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2005)
      Cell culture is highly desirable, as it provides systems for ready, direct access and evaluation of tissues. The use of tissue culture is a valuable tool to study problems of clinical relevance, especially those related ...
    • Dynamin-2 nervous system disorders 
      González Jamett, Arlek M.; Aro Acuña, Valentina; Momboisse, Fanny; Caviedes Fernández, Pablo; Bevilacqua, Jorge; Cárdenas, Ana María (International Society for Neurochemistry, 2014)
      Dynamin-2 is a pleiotropic GTPase whose best-known function is related to membrane scission during vesicle budding from the plasma or Golgi membranes. In the nervous system, dynamin-2 participates in synaptic vesicle ...
    • Intracellular calcium and arachidonic acid increase SNAP-25 expression in cultured rat hippocampal explants, ... 
      Sepúlveda, C. M.; Troncoso, C. C.; Lara Peñaloza, Hernán; Cárdenas, Ana María (ELSEVIER SCI IRELAND LTD, 1998-08-14)
      The effects of the increase of intracellular calcium, induced by membrane depolarization with 50 mM KCl, and arachidonic acid (AA) on the expression of 25-kD synaptosomal-associated protein (SNAP-25) were studied in cultured ...
    • Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the ... 
      Opazo, Patricia; Saud, Katherine; Saint Pierre, Michelle de; Cárdenas, Ana María; Allen, David D.; Segura Aguilar, Juan; Caviedes Codelia, Raúl; Caviedes Fernández, Pablo (WILEY-LISS, 2006-11-01)
      We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS-related genes (App, amyloid precursor protein; Sod1, Cu/Zn superoxide dismutase) ...
    • Neuronal dysfunction in Down syndrome: Contribution of neuronal models in cell culture 
      Saud, Katherine; Arriagada Abarzúa, Christian; Cárdenas, Ana María; Shimahara, Takeshi; Allen, David D.; Caviedes Codelia, Raúl; Caviedes Fernández, Pablo (ELSEVIER, 2006-05)
      Down syndrome (DS) in humans, or trisomy of autosome 21, represents the hyperdiploidy that most frequently survives gestation, reaching an incidence of I in 700 live births. The condition is associated with multisystemic ...
    • Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity ... 
      Pérez-Núñez, Ramón; Barraza, Natalia; Gonzalez-Jamett, Arlek; Cárdenas, Ana María; Barnier, Jean Vianney; Caviedes, Pablo (Springer New York LLC, 2016)
      © 2016, Springer Science+Business Media New York.In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset ...
    • Participación del receptor de IP3 en la inserción de canales de potasio tipo shaker en la membrana ... 
      Gayol Molinari, Silvina Beatriz (Universidad de Chile, 2008)
      Desde su sitio de síntesis, en los ribosomas, hasta su lugar de destino, en la membrana, Las proteínas de la membrana plasmática (MP) son transportadas en vesículas que atraviesan varias y complejas estructuras membranosas ...