Browsing by Author "Córdova Delgado, Miguel Angel"

Now showing items 1-5 of 5

    • A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict ... 
      Córdova Delgado, Miguel Angel; Bravo, María Loreto; Cumsille, Elisa; Hill, Charlotte N.; Muñoz Medel, Matías; Pinto, Mauricio P.; Retamal, Ignacio N.; Lavanderos, María; Miquel, Juan Francisco; Rodríguez Fernández, María (BMC, 2021)
      Background: Fluoropyrimidine plus platinum chemotherapy remains the standard first line treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD genotypes related to severe ...
    • Case report: molecular features and treatment options for small bowel adenocarcinoma 
      Córdova Delgado, Miguel Angel; Pizarro, Gonzalo; Pinto, Mauricio P.; Herrera, María Elisa; Garrido, Marcelo (Frontiers Media, 2021)
      Small bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main ...
    • FRI-1 is an anti-cancer isoquinolinequinone that inhibits the mitochondrial bioenergetics and blocks metabolic ... 
      Córdova Delgado, Miguel Angel; Fuentes Retamal, Sebastián Andrés; Palominos, Charlotte; López Torres, Camila Alejandra; Guzmán Rivera, Daniela; Ramírez Rodríguez, Oney; Araya Maturana, Ramiro; Urra Faúndez, Félix Ariel (MDPI, 2021)
      Since breast cancer (BC) cells are dependent on mitochondrial bioenergetics for promoting proliferation, survival, and metastasis, mitochondria highlight as an important target for anticancer drug discovery. FRI-1, methyl ...
    • Mutational landscape and actionable target rates on advanced stage refractory cancer patients: a multicenter ... 
      Córdova Delgado, Miguel Angel; Pinto, Mauricio P.; Regonesi, Carlos; Cereceda, Luis; Reyes, José Miguel; Itriago, Laura; Majlis, Alejandro; Rodríguez, Pablo; Fassler, André; Mahave, Mauricio; León, María Elisa; Gallardo, Jorge; Rodríguez Z., María Paz; Berkovits, Alejandro; Manque, Patricio; Ríos, Juvenal A.; García Bloj, Benjamín; Garrido, Marcelo (MDPI, 2022)
      Major advances in sequencing technologies and targeted therapies have accelerated the incorporation of oncology into the era of precision medicine and "biomarker-driven" treatments. However, the impact of this approach on ...
    • Proteogenomic analysis in an early onset diffuse gastric cancer patient revealed alterations in PIK3R1, ... 
      Córdova Delgado, Miguel Angel; Pinto, Mauricio P.; Pizarro, Gonzalo; Koch, Elard; Vargas, Cristian; Hernández, Mauricio; Nourdin, Guillermo; Saldivia, Pablo; Rodríguez Z., María Paz; Berkovits, Alejandro; Manque, Patricio; Rios, Juvenal A.; Garcia-Bloj, Benjamín; Garrido, Marcelo (AME Publishing Company, 2022)
      Background: Early-onset gastric cancers (EOGC) are poor prognosis hard-to treat malignancies that affect young individuals (<45 years old). Case Description: Herein we describe the case of a 26-year-old female EOGC patient ...