Browsing by Author "Carrasco, Carlos M."

Now showing items 1-3 of 3

    • Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP plus /MPTP-Lesioned ... 
      Aguirre, Pabla; Mena, Natalia P.; Carrasco, Carlos M.; Muñoz, Yorka; Pérez Henríquez, Patricio; Morales, Rodrigo A.; Cassels Niven, Bruce; Méndez Gálvez, Carolina; García Beltrán, Olimpo; González Billault, Christian; Núñez González, Marco (Public Library Science, 2015)
      Neuronal death in Parkinson's disease (PD) is often preceded by axodendritic tree retraction and loss of neuronal functionality. The presence of non-functional but live neurons opens therapeutic possibilities to recover ...
    • Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders 
      Mena, Natalia P.; Urrutia, Pamela J.; Lourido, Fernanda; Carrasco, Carlos M.; Núñez González, Marco (Elsevier, 2015)
      Synthesis of the iron-containing prosthetic groups—heme and iron–sulfur clusters—occurs in mitochondria. The mitochondrion is also an important producer of reactive oxygen species (ROS), which are derived fromelectrons leaking ...
    • Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation 
      Falcón Urrutia, Paulina; Carrasco, Carlos M.; Lois, Pablo; Palma, Verónica; Roth Metcalfe, Alejandro Darío (Public Library Science, 2015)
      Primary Cilia (PC) are a very likely place for signal integration where multiple signaling pathways converge. Two major signaling pathways clearly shown to signal through the PC, Sonic Hedgehog (Shh) and PDGF-Ra, are ...