Browsing by Author "Cornejo, Alberto"
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Areche, Carlos; Zapata, Francisca; González, Mathias; Díaz, Esteban; Montecinos, Rubén; Hernández, Marcos; Melo, Francisco; Cornejo, Alberto (Wiley-VCH Verlag, 2019)Tau protein is a natively unfolded protein whose primary role is to participate in axonal transport closely associated with microtubules. Neurodegenerative disorders including Alzheimer's disease and Tauopathies involved ...
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Salgado, Francisco; Caballero, Julio; Vargas, Reinaldo; Cornejo, Alberto; Areche, Carlos (Taylor & Francis, 2020)Alzheimer s disease (AD) is the most common form of dementia involving Ab and tau protein. So far, AD cure remains elusive, but considering that AD progresses throughout tau pathology, which turns tau protein an appropriate ...
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Cornejo, Alberto; Caballero, Julio; Simirgiotis, Mario; Torres, Vanessa; Sánchez, Luisa; Díaz, Nicolás; Guimaraes, Marcela; Hernández, Marcos; Areche Medina, Carlos Alberto; Alfaro, Sergio; Caballero, Leonardo; Melo, Francisco (Taylor & Francis Ltd., 2021)Parkinson’s disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit ...
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Cornejo, Alberto; Aguilar Sandoval, Felipe; Caballero, Leonardo; Machuca, Luis; Muñoz, Patricio; Caballero, Julio; Perry, George; Ardiles, Alejandro; Areche Medina, Carlos; Melo, Francisco (Taylor & Francis, 2017)Alzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts targeting amyloid-b plaques have succeeded to remove plaques but failed in clinical trials to improve ...
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Areche Medina, Carlos; Benites, Julio; Cornejo, Alberto; Ruiz, Lina M.; García Beltrán, Olimpo; Simirgiotis, Mario J.; Sepúlveda, Beatriz (2015)Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the ...
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González, Camila; Cartagena, Constanza; Caballero, Leonardo; Melo, Francisco; Areche Medina, Carlos Alberto; Cornejo, Alberto (MDPI, 2021)Neurodegenerative disorders, including Tauopathies that involve tau protein, base their pathological mechanism on forming proteinaceous aggregates, which has a deleterious effect on cells triggering an inflammatory ...