Browsing by Author "Díaz, Jorge"

Now showing items 1-9 of 9

    • A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion 
      Díaz, Jorge; Mendoza, Pablo; Silva, Patricio; Quest, Andrew F. G.; Torres, Vicente A. (Landes Bioscience, 2014)
      © Jorge Díaz, Pablo endoza, Patricio Silva, Andrew FG Quest, and Vicente A Torres. The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has ...
    • Caveolin-1 expression increases upon maturation in dendritic cells and promotes their migration to lymph ... 
      Oyarce, César; Cruz Gómez, Sebastián; Gálvez Cancino, Felipe Ignacio; Vargas, Pablo; Moreau, Hélène D.; Díaz Valdivia, Natalia; Díaz, Jorge; Salazar Onfray, Flavio; Pacheco, Rodrigo; Lennon Duménil, Ana María; Quest, Andrew F. G.; Lladser, Álvaro (Frontiers Media, 2017)
      Dendritic cell (DC) trafficking from peripheral tissues to lymph nodes (LNs) is a key step required to initiate T cell responses against pathogens as well as tumors. In this context, cellular membrane protrusions and the ...
    • Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast ... 
      Campos, America; Salomon, Carlos; Bustos, Rocio; Díaz, Jorge; Martínez, Samuel; Silva, Veronica; Reyes, Constanza; Díaz Valdivia, Natalia; Varas Godoy, Manuel; Lobos González, Lorena; Quest, Andrew F. G. (Future Medicine Ltd., 2018)
      © 2018 2018 Future Medicine Ltd. Breast cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths in women worldwide, whereby mortality is largely attributable to the development ...
    • Disease duration and disability in dysfeRlinopathy can be described by muscle imaging using heatmaps and ... 
      Gómez-Andrés, David; Díaz, Jorge; Munell, Francina; Sánchez-Montáñez, Ángel; Pulido-Valdeolivas, Irene; Suazo, Lionel; Garrido, Cristián; Quijano-Roy, Susana; Bevilacqua, Jorge A. (John Wiley and Sons Inc., 2019)
      © 2018 Wiley Periodicals, Inc.Introduction: The manner in which imaging patterns change over the disease course and with increasing disability in dysferlinopathy is not fully understood. Methods: Fibroadipose infiltration ...
    • Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation 
      Silva, Patricio; Soto, Nicolás; Díaz, Jorge; Mendoza, Pablo; Díaz, Natalia; Quest, Andrew F. G.; Torres Gómez, Vicente (Elsevier, 2015)
      The early endosomal protein Rab5 is highly expressed in tumor samples, although a causal relationship between Rab5 expression and cell transformation has not been established. Here, we report the functional effects of ...
    • Intracellular ca2+ increases and connexin 43 hemichannel opening are necessary but not sufficient for ... 
      Lagos Cabré, Raúl; Brenet, Marianne; Díaz, Jorge; Pérez, Ramón D.; Pérez, Leonardo A.; Herrera Molina, Rodrigo; Quest, Andrew F. G.; Leyton Campos, Lisette (MDPI AG, 2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Under pro-inflammatory conditions, astrocytes become reactive and acquire a migratory phenotype. Our results show that hemichannels formed by connexin 43 (Cx43) ...
    • Mitochondrial dysfunction and the glycolytic switch induced by caveolin-1 phosphorylation promote cancer ... 
      Díaz Valdivia, Natalia; Simón, Layla; Díaz, Jorge; Martínez Meza, Samuel; López Contreras, Pamela; Burgos Ravanal, Renato; Pérez, Viviana; Frei, Balz; Leyton Campos, Lisette; Quest, Andrew Frederick Geoffery (MDPI, 2022)
      Simple Summary Caveolin-1 (CAV1) is a membrane protein that has been attributed a dual role in cancer, acting at early stages as a tumor suppressor and in later stages of the disease as a promoter of metastasis. In the ...
    • Rab5 is required in metastatic cancer cells for caveolin-1-enhanced Rac1 activation, migration and invasion 
      Díaz, Jorge; Mendoza, Pablo; Ortiz, Rina; Díaz, Natalia; Leyton Campos, Lisette; Stupack, Dwayne; Quest, Andrew F. G.; Torres, Vicente A. (Company of Biologists Ltd, 2014)
      Rab5 is a small GTPase that regulates early endosome trafficking and other cellular processes, including cell adhesion and migration. Specifically, Rab5 promotes Rac1 activation and cancer cell migration, but little is ...
    • Thy-1 (CD90)-induced metastatic cancer cell migration and invasion are β3 integrin-dependent and involve a ... 
      Brenet Rivas, Marianne del Pilar; Martínez, Samuel; Pérez Núñez, Ramón; Pérez González, Leonardo Andrés; Contreras, Pamela; Díaz, Jorge; Ávalos, Ana María; Schneider, Pascal; Quest, Andrew Frederick Geoffery; Leyton Campos, Lisette (Frontiers Media, 2021)
      Cancer cell adhesion to the vascular endothelium is an important step in tumor metastasis. Thy-1 (CD90), a cell adhesion molecule expressed in activated endothelial cells, has been implicated in melanoma metastasis by ...