Browsing by Author "Díaz, Natalia"

Now showing items 1-5 of 5

    • Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the ... 
      Urra, Hery; Torres Gómez, Vicente; Ortiz, Rina J.; Lobos, Lorena; Díaz, María I.; Díaz, Natalia; Härtel, Steffen; Leyton Campos, Lisette; Quest, Andrew F. G. (PUBLIC LIBRARY SCIENCE, 2012-04-10)
      Caveolin-1 is known to promote cell migration, and increased caveolin-1 expression is associated with tumor progression and metastasis. In fibroblasts, caveolin-1 polarization and phosphorylation of tyrosine-14 are essential ...
    • Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation 
      Silva, Patricio; Soto, Nicolás; Díaz, Jorge; Mendoza, Pablo; Díaz, Natalia; Quest, Andrew F. G.; Torres Gómez, Vicente (Elsevier, 2015)
      The early endosomal protein Rab5 is highly expressed in tumor samples, although a causal relationship between Rab5 expression and cell transformation has not been established. Here, we report the functional effects of ...
    • E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells 
      Lobos González, Lorena; Aguilar, Lorena; Díaz Jara, Jorge; Díaz, Natalia; Urra, Hery; Torres Gómez, Vicente; Silva, Verónica; Fitzpatrick, Christopher; Lladser, Álvaro; Hoek, Keith S.; Leyton Campos, Lisette; Quest, Andrew F. G. (2013)
      Theroleofcaveolin-1(CAV1)incancerishighlycontroversial.CAV1suppressesgenesthatfavortumordevelopment, yet also promotes focal adhesion turnover and migration of metastatic cells. How these contrasting observations relate ...
    • Rab5 is required in metastatic cancer cells for caveolin-1-enhanced Rac1 activation, migration and invasion 
      Díaz, Jorge; Mendoza, Pablo; Ortiz, Rina; Díaz, Natalia; Leyton Campos, Lisette; Stupack, Dwayne; Quest, Andrew F. G.; Torres, Vicente A. (Company of Biologists Ltd, 2014)
      Rab5 is a small GTPase that regulates early endosome trafficking and other cellular processes, including cell adhesion and migration. Specifically, Rab5 promotes Rac1 activation and cancer cell migration, but little is ...
    • Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent ... 
      Fernández, Jaime G.; Rodríguez, Diego A.; Valenzuela, Manuel; Calderon, Claudia; Urzúa, Ulises; Munroe, David; Rosas, Carlos; Lemus, David; Díaz, Natalia; Wright, Mathew C.; Leyton Campos, Lisette; Tapia, Julio C.; Quest, Andrew F. G. (BioMed Central Ltd., 2014)
      © 2014 Fernández et al.; licensee BioMed Central Ltd.Early in cancer development, tumour cells express vascular endothelial growth factor (VEGF), a secreted molecule that is important in all stages of angiogenesis, an ...