Browsing by Author "Díaz Vegas, Alexis"

Now showing items 1-8 of 8

    • Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells 
      López Crisosto, Camila Paz; Díaz Vegas, Alexis; Castro, Pablo F.; Rothermel, Beverly A.; Bravo Sagua, Roberto Francisco; Lavandero González, Sergio Alejandro (SpringerNature, 2021)
      Subcellular organelles communicate with each other to regulate function and coordinate responses to changing cellular conditions. The physical-functional coupling of the endoplasmic reticulum (ER) with mitochondria allows ...
    • GDF-11 prevents cardiomyocyte hypertrophy by maintaining the sarcoplasmic reticulum-mitochondria communication 
      Garrido-Moreno, Valeria; Díaz Vegas, Alexis; López Crisosto, Camila; Troncoso, Mayarling Francisca; Navarro Márquez, Mario F.; García Nannig, Lorena; Estrada, Manuel; Cifuentes, Mariana; Lavandero González, Sergio (Academic Press, 2019)
      Growth differentiation factor 11 (GDF11) is a novel factor with controversial effects on cardiac hypertrophy both in vivo and in vitro. Although recent evidence has corroborated that GDF11 prevents the development of cardiac ...
    • Insulin-Dependent H2O2 Production Is Higher in Muscle Fibers of Mice Fed with a High-Fat Diet 
      Espinosa, Alejandra; Campos, Cristian; Díaz Vegas, Alexis; Galgani Fuentes, José; Juretic Díaz, Nevenka Militza; Osorio Fuentealba, César; Bucarey, José L.; Tapia, Gladys; Valenzuela, Rodrigo; Contreras Ferrat, Ariel Eduardo; Llanos Vidal, Paola; Jaimovich Pérez, Enrique (2013)
      Insulin resistance is defined as a reduced ability of insulin to stimulate glucose utilization. C57BL/6 mice fed with a high-fat diet (HFD) are a model of insulin resistance. In skeletal muscle, hydrogen peroxide (H2O2) ...
    • IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice 
      Valladares, Denisse; Utreras Mendoza, Yildy; Campos, Cristian; Morales, Camilo; Díaz Vegas, Alexis; Contreras Ferrat, Ariel Eduardo; Westermeier, Francisco; Jaimovich Pérez, Enrique; Marchi, Saverio; Pinton, Paolo; Lavandero González, Sergio (Elsevier B.V., 2018)
      © 2018 Duchenne muscular dystrophy (DMD) is characterized by a severe and progressive destruction of muscle fibers associated with altered Ca2+ homeostasis. We have previously shown that the IP3 receptor (IP3R) plays a ...
    • NOX2-Dependent ROS Production is Essential for the Response to Endurance Exercise in Skeletal Muscle 
      Henríquez Olguín, Carlos; Valladares Ide, Denisse; Díaz Vegas, Alexis; Utreras Mendoza, Yildy; Campos, Cristian; Llanos Vidal, Paola; Contreras Ferrat, Ariel Eduardo; Espinosa Escalona, Alejandra; Altamirano, Francisco; Arias Calderón, Manuel (Federation of American Societies for Experimental Biology, 2015)
    • ROS Production via P2Y(1)-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal ... 
      Díaz Vegas, Alexis; Campos, Cristian A.; Contreras Ferrat, Ariel Eduardo; Casas Atala, Mariana; Buvinic Radic, Sonja; Jaimovich Pérez, Enrique; Espinosa Escalona, Alejandra (Public Library Science, 2015)
      During exercise, skeletal muscle produces reactive oxygen species (ROS) via NADPH oxidase (NOX2) while inducing cellular adaptations associated with contractile activity. The signals involved in this mechanism are still a ...
    • ROS production via P2Y1-PKC-NOX2 is triggered by extracellular ATP after electrical stimulation of skeletal ... 
      Díaz Vegas, Alexis; Campos, Cristian A.; Contreras Ferrat, Ariel Eduardo; Casas, Mariana; Buvinic, Sonja; Jaimovich Pérez, Enrique; Espinosa, Alejandra (Public Library of Science, 2015)
      © 2015 Díaz-Vegas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
    • Skeletal muscle excitation-metabolism coupling 
      Díaz Vegas, Alexis; Eisner, Verónica; Jaimovich Pérez, Enrique (Academic Press Inc., 2019)
      Mitochondria represent the main source of ATP in skeletal muscle and mitochondria activity increases after muscle fiber depolarization. The regulation of mitochondrial function during contraction in skeletal muscle, however, ...