Browsing by Author "Donoso Laurent, Paulina"

Now showing items 1-9 of 9

    • Arritmogénesis en ratones alimentados con dieta rica en grasas saturadas 
      Araneda Ríos, Felipe (Universidad de Chile, 2017)
      La obesidad es un problema de salud pública. Se ha demostrado el desarrollo directo de falla cardiaca secundaria, con manifestaciones clínicas precoces y sutiles, como por ejemplo una mayor frecuencia de episodios de ...
    • Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion 
      Pedrozo Cibils, Zully; Sánchez, G.; Torrealba, N.; Valenzuela, Rodrigo; Fernández, Carolina; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio; Donoso Laurent, Paulina (ELSEVIER SCIENCE BV, 2010-03)
      Type-2 ryanodine receptors (RyR2) - the calcium release channels of cardiac sarcoplasmic reticulum - have a central role in cardiac excitation-contraction coupling. In the heart, ischemia/reperfusion causes a rapid and ...
    • Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy 
      Pedrozo Cibils, Zully; Torrealba, Natalia; Fernández, Carolina; Gatica, Damián; Toro, Barbra; Quiroga, Clara; Rodríguez, Andrea E.; Sánchez, Gina; Gillette, Thomas G.; Hill, Joseph A.; Donoso Laurent, Paulina; Lavandero González, Sergio (the European Society of Cardiology, 2013)
      Aims Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where ...
    • Exercise preconditioning of myocardial infarct size in dogs is triggered by calcium 
      Parra, Víctor M.; Macho Fisher, Pilar; Sánchez, Gina; Donoso Laurent, Paulina; Domenech Lira, Raúl (Lippincott Williams and Wilkins, 2015)
      We showed that exercise induces early and late myocardial preconditioning in dogs and that these effects are mediated through nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase activation. As the ...
    • Getting to the heart of mechanotransduction 
      Donoso Laurent, Cecilia; Donoso Laurent, Paulina (2011)
      Stretching a heart muscle cell triggers signaling by reactive oxygen species to produce Ca 2+ sparks.
    • Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex 
      Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Gálvez, Jorge; Sánchez, Gina; Donoso Laurent, Paulina; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (2008)
      Cerebral ischemia stimulates Ca2+influx and thus increases neuronal intracellular free [Ca2+. Using a rat model of cerebral ischemia without recirculation, we tested whether ischemia enhances the activation by Ca2+ of ...
    • Papel de la policistina-1 en el daño inducido por la isquemia/reperfusión cardíaca 
      Romero Romano, Pablo (Universidad de Chile, 2017)
      Las enfermedades cardiovasculares corresponden a una de las mayores causas de muerte en el mundo, donde el infarto agudo del miocardio es responsable de la mayoría de ellas. Diferentes vías confluyen en el daño y muerte ...
    • The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury 
      Salas, Margarita A.; Valverde, Carlos A.; Sánchez, Gina; Said, Matilde; Rodríguez, Jesica S.; Portiansky, Enrique L.; Kaetzel, Marcia A.; Dedman, John R.; Donoso Laurent, Paulina; Kranias, Evangelia G.; Mattiazzi, Alicia (ELSEVIER, 2010)
      Ca2+-calmodulin-dependent protein kinase II (CaMKII) plays an important role mediating apoptosis/ necrosis during ischemia-reperfusion (IR). We explored the mechanisms of this deleterious effect. Langendorff perfused rat ...
    • Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle 
      Sánchez, Gina; Pedrozo Cibils, Zully; Domenech Lira, Raúl; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2005-12)
      We have shown previously that electrically induced tachycardia effectively produces myocardial preconditioning. Among other effects, tachycardia increases calcium release rates in microsomal fractions enriched in sarcoplasmic ...