Browsing by Author "Esparza, Andrés"

Now showing items 1-4 of 4

    • Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central ... 
      Urrutia, Pamela J.; Aguirre, Pabla; Esparza, Andrés; Tapia, Victoria; Mena, Natalia P.; Arredondo Olguín, Miguel Armando; González Billault, Christian; Núñez González, Marco (2013)
      Inflammation and iron accumulation are present in a variety of neurodegenerative diseases that include Alzheimer’s disease and Parkinson’s disease. The study of the putative association between inflammation and iron ...
    • Iron-induced reactive oxygen species mediate transporter DMT1 endocytosis and iron uptake in intestinal ... 
      Esparza, Andrés; Gerdtzen Hakim, Ziomara; Olivera Nappa, Álvaro; Salgado Herrera, José Cristián; Núñez González, Marco (American Physiological Society, 2015)
      Recent evidence shows that iron induces the endocytosis of the iron transporter dimetal transporter 1 (DMT1) during intestinal absorption. We, and others, have proposed that iron-induced DMT1 internalization underlies the ...
    • Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells 
      Núñez González, Marco; Gallardo, Vivian; Muñoz, Patricia; Tapia, Victoria; Esparza, Andrés; Salazar, Julio; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2004-10-01)
      Glutathione (GSH) constitutes the single most important antioxidant in neurons, whereas iron causes oxidative stress that leads to cell damage and death. Although GSH and iron produce opposite effects on redox cell status, ...
    • Regulation of transepithelial transport of iron by hepcidin 
      Mena, Natalia P.; Esparza, Andrés; Núñez González, Marco (2006)
      Hepcidin (Hepc) is a 25 amino acid cationic peptide with broad antibacterial and antifungal actions. A likely role for Hepc in iron metabolism was suggested by the observation that mice having disruption of the gene encoding ...