Browsing by Author "Ezquer, Fernando"

Now showing items 1-11 of 11

    • A dual treatment blocks alcohol binge-drinking relapse: microbiota as a new player 
      Ezquer, Fernando; Quintanilla González, María Elena; Morales Retamales, Eugenia; Santapaul, Daniela; Munita, José Manuel; Moya Flores, Francisco; Ezquer, Marcelo; Herrera Marschitz, Mario; Israel Jacard, Yedy (Elsevier, 2022)
      Rationale: Gut microbiota communicates information to the brain. Some animals are born with a gut microbiota that predisposes to high alcohol consumption, and transplantation of fecal material from alcoholics to mice ...
    • A novel morphine drinking model of opioid dependence in rats 
      Berrios Cárcamo, Pablo; Quezada, Mauricio; Santapau, Daniela; Morales Retamales, Eugenia; Olivares, Belén; Ponce, Carolina; Ávila, Alba; Gregorio, Cristian de; Ezquer, Marcelo; Quintanilla González, María Elena; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy; Ezquer, Fernando (MDPI, 2022)
      An animal model of voluntary oral morphine consumption would allow for a pre-clinical evaluation of new treatments aimed at reducing opioid intake in humans. However, the main limitation of oral morphine consumption in ...
    • Administration of N-acetylcysteine plus acetylsalicylic acid markedly inhibits nicotine reinstatement ... 
      Quintanilla González, María Elena; Morales Retamales, Paola; Ezquer, Fernando; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel, Yedy (Frontiers Media, 2021)
      Background Nicotine is the major addictive component of cigarette smoke and the prime culprit of the failure to quit smoking. Common elements perpetuating the use of addictive drugs are (i) cues associated with the ...
    • Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: ... 
      Ezquer, Fernando; Núñez González, Marco; Israel Jacard, Yedy (PERGAMON-ELSEVIER SCIENCE LTD, 2005-06-01)
      Hereditary hemochromatosis (HH) is a condition in which intestinal iron absorption is greatly elevated. Present treatment is weekly phlebotomy, affecting quality of life and leading to recurrent infections. The iron ...
    • Hereditary hemochromatosis: An opportunity for gene therapy 
      Ezquer, Fernando; Núñez González, Marco; Rojas, Alejandro; Asenjo de Leuze, Juan; Israel Jacard, Yedy (SOCIEDAD BIOLGIA CHILE, 2006)
      Levels of body iron should be tightly controlled to prevent the formation of oxygen radicals. lipoperoxidation. genotoxicity, and the production of cytotoxic cytokines, which result in damage to a number of organs. Enterocytes ...
    • Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol ... 
      Ezquer, Fernando; Morales Retamales, Paola; Quintanilla González, María Elena; Santapau, Daniela; Lespay Rebolledo, Carolyne; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Nature, 2018)
      Chronic alcohol intake leads to neuroinflammation and astrocyte dysfunction, proposed to perpetuate alcohol consumption and to promote conditioned relapse-like binge drinking. In the present study, human mesenchymal stem ...
    • Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment ... 
      Ezquer, Marcelo; Urzúa Salinas, Cristhian; Montecino, Scarleth; Conget, Paulette; Ezquer, Fernando (BioMed Central, 2016)
      Background: Diabetic retinopathy is a common complication of diabetes and the leading cause of irreversible vision loss in the Western world. The reduction in color/contrast sensitivity due to the loss of neural cells in ...
    • Neonatal mesenchymal stem cell treatment improves myelination impaired by global perinatal asphyxia in rats 
      Tapia Bustos, Andrea Constanza; Lespay Rebolledo, Carolyne; Vío Grossi, María Valentina; Pérez Lobos, Ronald; Casanova Ortiz, Emmanuel Alberto; Ezquer, Fernando; Herrera-Marschitz Muller, Mario Guillermo Gustavo; Morales Retamales, Eugenia Paola (MDPI, 2020)
      The effect of perinatal asphyxia (PA) on oligodendrocyte (OL), neuroinflammation, and cell viability was evaluated in telencephalon of rats at postnatal day (P)1, 7, and 14, a period characterized by a spur of neuronal ...
    • Nerve Excitability and Structural Changes in Myelinated Axons from Diabetic Mice 
      Campero Soffia, Mario; Ezquer, M.; Ezquer, Fernando (Johann Ambrosius Barth Verlag Medizinverlage Heidelberg GMBH, 2015)
      Objective: The mechanisms associated with nerve dysfunction and axonal loss in diabetes has not been fully clarified. Excitability and pathological aspects in nerves from diabetic mice were studied in order to explore the ...
    • Neuronal rubicon represses extracellular APP/amyloid beta deposition in Alzheimer's disease 
      Espinoza, Sandra; Grunenwald, Felipe; Gomez, Wileidy; García, Felipe; Abarzúa Catalán, Lorena; Oyarce Pezoa, Sebastián; Hernández, María Fernanda; Cortés, Bastián I.; Uhrig, Markus; Ponce de la Vega, Daniela Paz; Durán Aniotz, Claudia; Hetz Flores, Claudio Andres; San Martín Rovirosa, Carol Dazil; Cornejo Corona, Víctor Hugo; Ezquer, Fernando; Parra Ortiz, Valentina María; Behrens Pellegrino, María Isabel Ofelia; Manque, Patricio A.; Rojas Rivera, Diego; Vidal, René L.; Woehlbier, Ute; Nassif, Melissa (MDPI, 2022)
      Alzheimer's disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates in neurons. Rubicon ...
    • Spatial maps and oscillations in the healthy hippocampus of octodon degus, a natural model of sporadic ... 
      Mugnaini, Matias; Polania Caviedes, Diana Marcela; Díaz, Yannina; Ezquer, Marcelo; Ezquer, Fernando; Deacon, Robert M. J.; Cogram, Patricia; Kropf, Emilio (Nature, 2022)
      The Octodon degus is a South American rodent that is receiving increased attention as a potential model of aging and sporadic late-onset Alzheimer's disease (AD). Impairments in spatial memory tasks in Octodon degus have ...