Browsing by Author "Fernández, Dominique"

Now showing items 1-6 of 6

    • CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression 
      Bono Merino, María Rosa; Fernández, Dominique; Flores Santibáñez, Felipe; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (Elsevietr, 2015)
      Extracellular ATP is a danger signal released by dying and damaged cells, and it functions as an immunostimulatory signal that promotes inflammation. However, extracellular adenosine acts as an immunoregulatory signal that ...
    • CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells 
      Flores Santibáñez, Felipe; Fernández, Dominique; Meza, Daniel; Tejón, Gabriela; Vargas, Leonardo; Varela Nallar, Lorena; Arredondo, Sebastián; Guixé Leguía, Victoria Cristina; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Wiley & Sons, 2015)
      The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up-regulated in T helper type 17 cells when generated in ...
    • Human cDC1s display constitutive activation of the UPRsensor IRE1 
      García González, Paulina; Fernández, Dominique; Gutiérrez Cabrera, Diane; Parra Cordero, Mauro; Osorio Olivares, Fabiola (Wiley, 2022)
      The intracellular mechanisms safeguarding DC function are of biomedical interest in several immune-related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation ...
    • T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 ... 
      Nuñez, Sarah; Saez, Juan José; Fernández, Dominique; Flores Santibañez, Felipe; Álvarez, Karla; Tejón, Gabriela; Ruiz, Paulina; Maldonado, Paula; Hidalgo, Yessia; Manriquez, Valeria; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (Blackwell Publishing, 2013)
      T helper type 17 (Th17) lymphocytes are found in high frequency in tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, ...
    • The demethylase inhibitor GSK‑J4 limits infammatory colitis by promoting de novo synthesis of retinoic acid ... 
      Doñas, Cristian; Neira, Jocelyn; Osorio Barrios, Francisco; Carrasco, Macarena; Fernández, Dominique; Prado, Carolina; Loyola, Alejandra; Pacheco, Rodrigo; Rosemblatt Silber, Mario César (Nature, 2021)
      Dendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders. Evidence from inflammatory ...
    • Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation 
      Tejón, Gabriela; Manríquez, Valeria; Calisto, Jaime, de; Flores Santibáñez, Felipe; Hidalgo, Yessia; Crisóstomo, Natalia; Fernández, Dominique; Sauma Mahaluf, Daniela; Mora, J.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César (Hindawi Publishing, 2015)
      Maintaining the identity of Foxp3+ regulatory T cells (Tregs) is critical for controlling immune responses in the gut, where an imbalance between Tregs and T effector cells has been linked to inflammatory bowel disease. ...