Browsing by Author "Ferreira, Jorge"
Now showing items 1-7 of 7
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(Sociedad de Biología de Chile, 2021)Background: Urushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8+ efector T-cells and downregulated by CD4+ T-cells. However, the molecular mechanism by which urushiols stimulate innate ...
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(Elsevier, 2013)Objectives: To evaluate the effect of benznidazole on endothelial activation in a murine model of Chagas disease. Methods: A low (30 mg/kg/day) and a high (100 mg/kg/day) dose of benznidazole were administered to mice ...
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(AMER SOC MICROBIOLOGY, 2008)L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden ...
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(2007)Current knowledge of the biochemistry of Trypanosonta cruzi has led to the development of new drugs and the understanding of their mode of action. Some trypanocidal drugs such as nifurtimox and benznidazole act through ...
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(Public Library Science, 2015)Chagas disease is one of the most neglected tropical diseases in the world, affecting nearly 15 million people, primarily in Latin America. Only two drugs are used for the treatment of this disease, nifurtimox and benznidazole. ...
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(Springer, 2013)Chronic Chagas’ disease affects 10–30 % of patients infected with Trypanosoma cruzi, and it mainly manifests as cardiomyopathy. Important pathophysiological mechanisms involved in the cardiac lesions include activation of ...
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(1986)t-Butyl-4-hydroxyanisole, an antioxidant food additive, inhibited the growth of Trypanosoma cruzi by almost 100% at 0.5 mM concentration. This compound inhibited 70% of oxygen consumption of epimastigotes. The redox level ...
